Association between Choroidal Thickness and Metabolic Activity on Positron Emission Tomography in Eyes with Choroidal Melanoma

Ji Hwan Lee, Sungchul Lee, Arthur Cho, Ki Chang Keum, Yang Gun Suh, Christopher Seungkyu Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose To investigate the relationship between subfoveal choroidal thickness and metabolic activity in eyes with choroidal melanoma. Design Retrospective, interventional case series. Methods The medical records of 16 patients with unilateral choroidal melanoma who underwent ruthenium (Ru) 106 brachytherapy with adjuvant transpupillary thermotherapy and who had available pretreatment positron emission tomography-computed tomography (PET-CT) images were retrospectively reviewed. Subfoveal choroidal thickness was measured in tumor eyes and in unaffected fellow eyes using enhanced-depth imaging spectral-domain optical coherence tomography (EDI OCT). Tumor eyes were divided into 2 groups (metabolically active and inactive) based on PET-CT findings and subfoveal choroidal thickness was compared between groups. Additionally, choroidal thickness measurements were compared before and after treatment. Results Before treatment, mean choroidal thickness was 293.31 ± 46.80 μm in tumor eyes and 242.44 ± 65.37 μm in fellow eyes, a difference that was statistically significant (P =.003). Eyes with metabolically active tumors had a significantly thicker choroid (348.00 ± 17.32 μm) than eyes with metabolically inactive tumors (280.69 ± 42.04 μm, P =.019). In tumor eyes, mean choroidal thickness significantly decreased from pretreatment values to 253.56 ± 61.27 μm 6 months after treatment (P =.018). Conclusion Eyes with choroidal melanoma had thicker choroids than unaffected fellow eyes. Increased choroidal thickness was more prominent in metabolically active tumors. Choroidal thickness significantly decreased in tumor eyes 6 months after treatment.

Original languageEnglish
Pages (from-to)1111-1115.e2
JournalAmerican Journal of Ophthalmology
Volume160
Issue number6
DOIs
Publication statusPublished - 2015 Jan 1

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Positron-Emission Tomography
Melanoma
Neoplasms
Choroid
Induced Hyperthermia
Ruthenium
Brachytherapy
Optical Coherence Tomography
Therapeutics
Medical Records

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Lee, Ji Hwan ; Lee, Sungchul ; Cho, Arthur ; Keum, Ki Chang ; Suh, Yang Gun ; Lee, Christopher Seungkyu. / Association between Choroidal Thickness and Metabolic Activity on Positron Emission Tomography in Eyes with Choroidal Melanoma. In: American Journal of Ophthalmology. 2015 ; Vol. 160, No. 6. pp. 1111-1115.e2.
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abstract = "Purpose To investigate the relationship between subfoveal choroidal thickness and metabolic activity in eyes with choroidal melanoma. Design Retrospective, interventional case series. Methods The medical records of 16 patients with unilateral choroidal melanoma who underwent ruthenium (Ru) 106 brachytherapy with adjuvant transpupillary thermotherapy and who had available pretreatment positron emission tomography-computed tomography (PET-CT) images were retrospectively reviewed. Subfoveal choroidal thickness was measured in tumor eyes and in unaffected fellow eyes using enhanced-depth imaging spectral-domain optical coherence tomography (EDI OCT). Tumor eyes were divided into 2 groups (metabolically active and inactive) based on PET-CT findings and subfoveal choroidal thickness was compared between groups. Additionally, choroidal thickness measurements were compared before and after treatment. Results Before treatment, mean choroidal thickness was 293.31 ± 46.80 μm in tumor eyes and 242.44 ± 65.37 μm in fellow eyes, a difference that was statistically significant (P =.003). Eyes with metabolically active tumors had a significantly thicker choroid (348.00 ± 17.32 μm) than eyes with metabolically inactive tumors (280.69 ± 42.04 μm, P =.019). In tumor eyes, mean choroidal thickness significantly decreased from pretreatment values to 253.56 ± 61.27 μm 6 months after treatment (P =.018). Conclusion Eyes with choroidal melanoma had thicker choroids than unaffected fellow eyes. Increased choroidal thickness was more prominent in metabolically active tumors. Choroidal thickness significantly decreased in tumor eyes 6 months after treatment.",
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Association between Choroidal Thickness and Metabolic Activity on Positron Emission Tomography in Eyes with Choroidal Melanoma. / Lee, Ji Hwan; Lee, Sungchul; Cho, Arthur; Keum, Ki Chang; Suh, Yang Gun; Lee, Christopher Seungkyu.

In: American Journal of Ophthalmology, Vol. 160, No. 6, 01.01.2015, p. 1111-1115.e2.

Research output: Contribution to journalArticle

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T1 - Association between Choroidal Thickness and Metabolic Activity on Positron Emission Tomography in Eyes with Choroidal Melanoma

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AU - Suh, Yang Gun

AU - Lee, Christopher Seungkyu

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N2 - Purpose To investigate the relationship between subfoveal choroidal thickness and metabolic activity in eyes with choroidal melanoma. Design Retrospective, interventional case series. Methods The medical records of 16 patients with unilateral choroidal melanoma who underwent ruthenium (Ru) 106 brachytherapy with adjuvant transpupillary thermotherapy and who had available pretreatment positron emission tomography-computed tomography (PET-CT) images were retrospectively reviewed. Subfoveal choroidal thickness was measured in tumor eyes and in unaffected fellow eyes using enhanced-depth imaging spectral-domain optical coherence tomography (EDI OCT). Tumor eyes were divided into 2 groups (metabolically active and inactive) based on PET-CT findings and subfoveal choroidal thickness was compared between groups. Additionally, choroidal thickness measurements were compared before and after treatment. Results Before treatment, mean choroidal thickness was 293.31 ± 46.80 μm in tumor eyes and 242.44 ± 65.37 μm in fellow eyes, a difference that was statistically significant (P =.003). Eyes with metabolically active tumors had a significantly thicker choroid (348.00 ± 17.32 μm) than eyes with metabolically inactive tumors (280.69 ± 42.04 μm, P =.019). In tumor eyes, mean choroidal thickness significantly decreased from pretreatment values to 253.56 ± 61.27 μm 6 months after treatment (P =.018). Conclusion Eyes with choroidal melanoma had thicker choroids than unaffected fellow eyes. Increased choroidal thickness was more prominent in metabolically active tumors. Choroidal thickness significantly decreased in tumor eyes 6 months after treatment.

AB - Purpose To investigate the relationship between subfoveal choroidal thickness and metabolic activity in eyes with choroidal melanoma. Design Retrospective, interventional case series. Methods The medical records of 16 patients with unilateral choroidal melanoma who underwent ruthenium (Ru) 106 brachytherapy with adjuvant transpupillary thermotherapy and who had available pretreatment positron emission tomography-computed tomography (PET-CT) images were retrospectively reviewed. Subfoveal choroidal thickness was measured in tumor eyes and in unaffected fellow eyes using enhanced-depth imaging spectral-domain optical coherence tomography (EDI OCT). Tumor eyes were divided into 2 groups (metabolically active and inactive) based on PET-CT findings and subfoveal choroidal thickness was compared between groups. Additionally, choroidal thickness measurements were compared before and after treatment. Results Before treatment, mean choroidal thickness was 293.31 ± 46.80 μm in tumor eyes and 242.44 ± 65.37 μm in fellow eyes, a difference that was statistically significant (P =.003). Eyes with metabolically active tumors had a significantly thicker choroid (348.00 ± 17.32 μm) than eyes with metabolically inactive tumors (280.69 ± 42.04 μm, P =.019). In tumor eyes, mean choroidal thickness significantly decreased from pretreatment values to 253.56 ± 61.27 μm 6 months after treatment (P =.018). Conclusion Eyes with choroidal melanoma had thicker choroids than unaffected fellow eyes. Increased choroidal thickness was more prominent in metabolically active tumors. Choroidal thickness significantly decreased in tumor eyes 6 months after treatment.

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