Association between depression and risk of Parkinson's disease in South Korean adults

Wonjeong Jeong, Hyunkyu Kim, Jae Hong Joo, Sung In Jang, Eun Cheol Park

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: Depression is considered a predictive factor for cognitive impairments. At the same time, Parkinson's disease (PD) is a growing public health problem. The aim of this study is to examine the association between depression and PD risk among South Korean adults. Methods: Data from 21,766 participants aged over 40, derived from the National Health Insurance Service National Sample Cohort (2002–2013), were included. Propensity score matching (1:1) was used to match participants with and without depression (case: 10,875, control: 10,875). The dependent variable was PD risk. A Cox proportional hazards regression model was built to analyze the associations between variables. Results: People with depression had a higher risk of PD than those without depression (hazard ratio (HR) = 1.61, 95% confidence interval (CI) = 1.26–2.06). Among individuals with disabilities, those with depression had a higher risk of PD (HR = 2.31, 95% CI = 1.08–4.94). According to the Charlson Comorbidity Index (CCI) score, those with depression had a higher risk of PD than their counterparts (CCI score ≥ 5: HR = 1.63, 95% CI = 1.21–2.20). Limitations: The limitations include the inability to 1) explore factors such as smoking and drinking status, which could be related to PD risk and 2) identify undiagnosed PD that already existed at the time of diagnosis of depression. Conclusions: The results suggest that having depression places individuals at a higher risk of PD. Interventions to alleviate the risk of PD should focus on adequate depression management.

Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalJournal of affective disorders
Volume292
DOIs
Publication statusPublished - 2021 Sep 1

Bibliographical note

Funding Information:
We would like to thank the colleagues from the Department of Public Health, Graduate School of Yonsei University provided advice for this manuscript.

Publisher Copyright:
© 2021 The Author(s)

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health

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