Association between diabetes mellitus and chronic rhinosinusitis with nasal polyps: A population-based cross-sectional study

Jae Sung Nam; Yun Ho Roh; Jungghi Kim; Suk Won Chang; Jong Gyun Ha; Jeong Jin Park; Wasan Almazouq Fahad; Joo Heon Yoon; Chang Hoon Kim; Hyung Ju Cho

doi:10.1111/coa.13884

Association between diabetes mellitus and chronic rhinosinusitis with nasal polyps: A population-based cross-sectional study

Jae Sung Nam, Yun Ho Roh, Jungghi Kim, Suk Won Chang, Jong Gyun Ha, Jeong Jin Park, Wasan Almazouq Fahad, Joo Heon Yoon, Chang Hoon Kim, Hyung Ju Cho

Department of Otorhinolaryngology

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To investigate the association between physician-diagnosed diabetes mellitus (DM) and chronic rhinosinusitis (CRS) phenotypes in a national population-based study. Study Design: Retrospective cross-sectional study. Setting: Population-based survey data were collected by the Korean National Health and Nutrition Survey between January 2008 and December 2012. Participants and Methods: A total of 34 670 participants aged over 19 years were enrolled in the Korea National Health and Nutrition Examination Surveys from 2008 to 2012. The relationship of CRS prevalence, with and without nasal polyps, with physician-diagnosed DM and non-DM were assessed. Differences in sinonasal symptoms between patients with and without DM were analysed in this cross-sectional study. Results: A significant association was observed between DM and CRS with nasal polyps after adjustment for multiple variables. No substantial association was observed between DM and CRS without nasal polyps. Among patients with CRS, olfactory dysfunction for >3 months was significantly more frequent in the DM group than in the non-DM group. Conclusion: We demonstrated significant associations between DM and CRS with nasal polyps and olfactory dysfunction among patients with CRS in a large national clinical cohort study. The direct mechanism of the association between DM and CRS with nasal polyps should be further investigated to clarify the pathogenesis of CRS with nasal polyps.

Original language	English
Pages (from-to)	167-173
Number of pages	7
Journal	Clinical Otolaryngology
Volume	47
Issue number	1
DOIs	https://doi.org/10.1111/coa.13884
Publication status	Published - 2022 Jan

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF‐2021R1A2C2010811) to H.J. Cho. This work was supported by the National Research Foundation of Korea (NRF‐2016M3A9D5A01952414) Grant funded by the Korean Government (MSIP) (No. 2016R1A5A2008630). This study was supported by the “Team Science Award” of Yonsei University College of Medicine (6‐2021‐0005). The funding sources had no role in the study design; in the collection, analysis, and interpretation of data; or in the writing of the manuscript

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2021R1A2C2010811) to H.J. Cho. This work was supported by the National Research Foundation of Korea (NRF-2016M3A9D5A01952414) Grant funded by the Korean Government (MSIP) (No. 2016R1A5A2008630). This study was supported by the ?Team Science Award? of Yonsei University College of Medicine (6-2021-0005). The funding sources had no role in the study design; in the collection, analysis, and interpretation of data; or in the writing of the manuscript The authors thank the Biostatistics Collaboration Unit at Yonsei University for their help with the statistical analyses.

Publisher Copyright:
© 2021 John Wiley & Sons Ltd

All Science Journal Classification (ASJC) codes

Otorhinolaryngology

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Cite this

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title = "Association between diabetes mellitus and chronic rhinosinusitis with nasal polyps: A population-based cross-sectional study",

abstract = "Objective: To investigate the association between physician-diagnosed diabetes mellitus (DM) and chronic rhinosinusitis (CRS) phenotypes in a national population-based study. Study Design: Retrospective cross-sectional study. Setting: Population-based survey data were collected by the Korean National Health and Nutrition Survey between January 2008 and December 2012. Participants and Methods: A total of 34 670 participants aged over 19 years were enrolled in the Korea National Health and Nutrition Examination Surveys from 2008 to 2012. The relationship of CRS prevalence, with and without nasal polyps, with physician-diagnosed DM and non-DM were assessed. Differences in sinonasal symptoms between patients with and without DM were analysed in this cross-sectional study. Results: A significant association was observed between DM and CRS with nasal polyps after adjustment for multiple variables. No substantial association was observed between DM and CRS without nasal polyps. Among patients with CRS, olfactory dysfunction for >3 months was significantly more frequent in the DM group than in the non-DM group. Conclusion: We demonstrated significant associations between DM and CRS with nasal polyps and olfactory dysfunction among patients with CRS in a large national clinical cohort study. The direct mechanism of the association between DM and CRS with nasal polyps should be further investigated to clarify the pathogenesis of CRS with nasal polyps.",

author = "Nam, {Jae Sung} and Roh, {Yun Ho} and Jungghi Kim and Chang, {Suk Won} and Ha, {Jong Gyun} and Park, {Jeong Jin} and Fahad, {Wasan Almazouq} and Yoon, {Joo Heon} and Kim, {Chang Hoon} and Cho, {Hyung Ju}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF‐2021R1A2C2010811) to H.J. Cho. This work was supported by the National Research Foundation of Korea (NRF‐2016M3A9D5A01952414) Grant funded by the Korean Government (MSIP) (No. 2016R1A5A2008630). This study was supported by the “Team Science Award” of Yonsei University College of Medicine (6‐2021‐0005). The funding sources had no role in the study design; in the collection, analysis, and interpretation of data; or in the writing of the manuscript Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2021R1A2C2010811) to H.J. Cho. This work was supported by the National Research Foundation of Korea (NRF-2016M3A9D5A01952414) Grant funded by the Korean Government (MSIP) (No. 2016R1A5A2008630). This study was supported by the ?Team Science Award? of Yonsei University College of Medicine (6-2021-0005). The funding sources had no role in the study design; in the collection, analysis, and interpretation of data; or in the writing of the manuscript The authors thank the Biostatistics Collaboration Unit at Yonsei University for their help with the statistical analyses. Publisher Copyright: {\textcopyright} 2021 John Wiley & Sons Ltd",

year = "2022",

month = jan,

doi = "10.1111/coa.13884",

language = "English",

volume = "47",

pages = "167--173",

journal = "Clinical Otolaryngology",

issn = "1749-4478",

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T1 - Association between diabetes mellitus and chronic rhinosinusitis with nasal polyps

T2 - A population-based cross-sectional study

AU - Nam, Jae Sung

AU - Roh, Yun Ho

AU - Kim, Jungghi

AU - Chang, Suk Won

AU - Ha, Jong Gyun

AU - Park, Jeong Jin

AU - Fahad, Wasan Almazouq

AU - Yoon, Joo Heon

AU - Kim, Chang Hoon

AU - Cho, Hyung Ju

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF‐2021R1A2C2010811) to H.J. Cho. This work was supported by the National Research Foundation of Korea (NRF‐2016M3A9D5A01952414) Grant funded by the Korean Government (MSIP) (No. 2016R1A5A2008630). This study was supported by the “Team Science Award” of Yonsei University College of Medicine (6‐2021‐0005). The funding sources had no role in the study design; in the collection, analysis, and interpretation of data; or in the writing of the manuscript Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (NRF-2021R1A2C2010811) to H.J. Cho. This work was supported by the National Research Foundation of Korea (NRF-2016M3A9D5A01952414) Grant funded by the Korean Government (MSIP) (No. 2016R1A5A2008630). This study was supported by the ?Team Science Award? of Yonsei University College of Medicine (6-2021-0005). The funding sources had no role in the study design; in the collection, analysis, and interpretation of data; or in the writing of the manuscript The authors thank the Biostatistics Collaboration Unit at Yonsei University for their help with the statistical analyses. Publisher Copyright: © 2021 John Wiley & Sons Ltd

PY - 2022/1

Y1 - 2022/1

N2 - Objective: To investigate the association between physician-diagnosed diabetes mellitus (DM) and chronic rhinosinusitis (CRS) phenotypes in a national population-based study. Study Design: Retrospective cross-sectional study. Setting: Population-based survey data were collected by the Korean National Health and Nutrition Survey between January 2008 and December 2012. Participants and Methods: A total of 34 670 participants aged over 19 years were enrolled in the Korea National Health and Nutrition Examination Surveys from 2008 to 2012. The relationship of CRS prevalence, with and without nasal polyps, with physician-diagnosed DM and non-DM were assessed. Differences in sinonasal symptoms between patients with and without DM were analysed in this cross-sectional study. Results: A significant association was observed between DM and CRS with nasal polyps after adjustment for multiple variables. No substantial association was observed between DM and CRS without nasal polyps. Among patients with CRS, olfactory dysfunction for >3 months was significantly more frequent in the DM group than in the non-DM group. Conclusion: We demonstrated significant associations between DM and CRS with nasal polyps and olfactory dysfunction among patients with CRS in a large national clinical cohort study. The direct mechanism of the association between DM and CRS with nasal polyps should be further investigated to clarify the pathogenesis of CRS with nasal polyps.

AB - Objective: To investigate the association between physician-diagnosed diabetes mellitus (DM) and chronic rhinosinusitis (CRS) phenotypes in a national population-based study. Study Design: Retrospective cross-sectional study. Setting: Population-based survey data were collected by the Korean National Health and Nutrition Survey between January 2008 and December 2012. Participants and Methods: A total of 34 670 participants aged over 19 years were enrolled in the Korea National Health and Nutrition Examination Surveys from 2008 to 2012. The relationship of CRS prevalence, with and without nasal polyps, with physician-diagnosed DM and non-DM were assessed. Differences in sinonasal symptoms between patients with and without DM were analysed in this cross-sectional study. Results: A significant association was observed between DM and CRS with nasal polyps after adjustment for multiple variables. No substantial association was observed between DM and CRS without nasal polyps. Among patients with CRS, olfactory dysfunction for >3 months was significantly more frequent in the DM group than in the non-DM group. Conclusion: We demonstrated significant associations between DM and CRS with nasal polyps and olfactory dysfunction among patients with CRS in a large national clinical cohort study. The direct mechanism of the association between DM and CRS with nasal polyps should be further investigated to clarify the pathogenesis of CRS with nasal polyps.

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Association between diabetes mellitus and chronic rhinosinusitis with nasal polyps: A population-based cross-sectional study

Abstract

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