Association between human cytomegalovirus antibody levels, and essential hypertension and functional status in elderly Koreans

Su Jin Jeong, Sang Hoon Han, Chang Oh Kim, JunYong Choi, Young Goo Song, June Myung Kim

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aim: To evaluate the relationship between human cytomegalovirus (HCMV) antibody status, and hypertension and functional status among elderly Koreans. Methods: Patients aged ≥65 years were prospectively enrolled from March 2011 to February 2012 at a 2000-bed university hospital. We collected data including CD4+ and CD8+ T-lymphocyte count, and functional status by measuring basic activities of daily living and instrumental activities of daily living for all patients. In addition, HCMV immunoglobulinG levels were analyzed using enzyme-linked fluorescent assay. Results: During the study period, 103 patients (51 men), who were admitted for treatment of infections or other diseases, were enrolled. Multivariate analysis showed that body mass index and HCMV immunoglobulinG antibody titers were independent factors associated with hypertension in elderly patients (OR 1.347, 95% CI 1.113-1.630, P=0.002; OR 1.023, 95% CI 1.001-1.047, P=0.042, respectively). In univariate linear correlations, HCMV antibody levels were positively correlated with systolic blood pressure levels (r=0.303, P=0.002), CD8+ T-lymphocyte count (r=0.313, P=0.001) and instrumental activities of daily living scores (r=0.217, P=0.028). In addition, HCMV immunoglobulinG titers were inversely associated with estimated glomerular filtration rate (r=-0.268, P=0.006). These four variables remained independently significant in multivariate correlation analysis. Conclusion: These findings could provide insight into the important role of HCMV in the pathogenesis of essential hypertension and decreased functional status in the elderly. Geriatr Gerontol Int 2016; 16: 21-27.

Original languageEnglish
Pages (from-to)21-27
Number of pages7
JournalGeriatrics and Gerontology International
Volume16
Issue number1
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

hypertension
Cytomegalovirus
Activities of Daily Living
Antibodies
Lymphocyte Count
multivariate analysis
Multivariate Analysis
Blood Pressure
Hypertension
Disease
T-Lymphocytes
university
Glomerular Filtration Rate
Essential Hypertension
Body Mass Index
Enzymes
Infection

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Gerontology
  • Geriatrics and Gerontology

Cite this

Jeong, Su Jin ; Han, Sang Hoon ; Kim, Chang Oh ; Choi, JunYong ; Song, Young Goo ; Kim, June Myung. / Association between human cytomegalovirus antibody levels, and essential hypertension and functional status in elderly Koreans. In: Geriatrics and Gerontology International. 2016 ; Vol. 16, No. 1. pp. 21-27.
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abstract = "Aim: To evaluate the relationship between human cytomegalovirus (HCMV) antibody status, and hypertension and functional status among elderly Koreans. Methods: Patients aged ≥65 years were prospectively enrolled from March 2011 to February 2012 at a 2000-bed university hospital. We collected data including CD4+ and CD8+ T-lymphocyte count, and functional status by measuring basic activities of daily living and instrumental activities of daily living for all patients. In addition, HCMV immunoglobulinG levels were analyzed using enzyme-linked fluorescent assay. Results: During the study period, 103 patients (51 men), who were admitted for treatment of infections or other diseases, were enrolled. Multivariate analysis showed that body mass index and HCMV immunoglobulinG antibody titers were independent factors associated with hypertension in elderly patients (OR 1.347, 95{\%} CI 1.113-1.630, P=0.002; OR 1.023, 95{\%} CI 1.001-1.047, P=0.042, respectively). In univariate linear correlations, HCMV antibody levels were positively correlated with systolic blood pressure levels (r=0.303, P=0.002), CD8+ T-lymphocyte count (r=0.313, P=0.001) and instrumental activities of daily living scores (r=0.217, P=0.028). In addition, HCMV immunoglobulinG titers were inversely associated with estimated glomerular filtration rate (r=-0.268, P=0.006). These four variables remained independently significant in multivariate correlation analysis. Conclusion: These findings could provide insight into the important role of HCMV in the pathogenesis of essential hypertension and decreased functional status in the elderly. Geriatr Gerontol Int 2016; 16: 21-27.",
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Association between human cytomegalovirus antibody levels, and essential hypertension and functional status in elderly Koreans. / Jeong, Su Jin; Han, Sang Hoon; Kim, Chang Oh; Choi, JunYong; Song, Young Goo; Kim, June Myung.

In: Geriatrics and Gerontology International, Vol. 16, No. 1, 01.01.2016, p. 21-27.

Research output: Contribution to journalArticle

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T1 - Association between human cytomegalovirus antibody levels, and essential hypertension and functional status in elderly Koreans

AU - Jeong, Su Jin

AU - Han, Sang Hoon

AU - Kim, Chang Oh

AU - Choi, JunYong

AU - Song, Young Goo

AU - Kim, June Myung

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N2 - Aim: To evaluate the relationship between human cytomegalovirus (HCMV) antibody status, and hypertension and functional status among elderly Koreans. Methods: Patients aged ≥65 years were prospectively enrolled from March 2011 to February 2012 at a 2000-bed university hospital. We collected data including CD4+ and CD8+ T-lymphocyte count, and functional status by measuring basic activities of daily living and instrumental activities of daily living for all patients. In addition, HCMV immunoglobulinG levels were analyzed using enzyme-linked fluorescent assay. Results: During the study period, 103 patients (51 men), who were admitted for treatment of infections or other diseases, were enrolled. Multivariate analysis showed that body mass index and HCMV immunoglobulinG antibody titers were independent factors associated with hypertension in elderly patients (OR 1.347, 95% CI 1.113-1.630, P=0.002; OR 1.023, 95% CI 1.001-1.047, P=0.042, respectively). In univariate linear correlations, HCMV antibody levels were positively correlated with systolic blood pressure levels (r=0.303, P=0.002), CD8+ T-lymphocyte count (r=0.313, P=0.001) and instrumental activities of daily living scores (r=0.217, P=0.028). In addition, HCMV immunoglobulinG titers were inversely associated with estimated glomerular filtration rate (r=-0.268, P=0.006). These four variables remained independently significant in multivariate correlation analysis. Conclusion: These findings could provide insight into the important role of HCMV in the pathogenesis of essential hypertension and decreased functional status in the elderly. Geriatr Gerontol Int 2016; 16: 21-27.

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