Association between impaired lung function and coronary artery calcium score in workers exposed to inorganic dust

Jin Ha Yoon, Byung Soon Choi, Jae Hoon Shin, So Young Park, You Lim Lee, Jang Young Kim, Won Jeong Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Reduced lung function, measured by forced vital capacity (FVC) and forced expiratory volume in 1 second (FEV1) are linked to oxidative stress and systemic inflammation, which are important in the pathogenesis of atherosclerosis. Here, we assessed the association between impaired lung function and atherosclerosis (measured by coronary artery calcium score) in workers exposed to inorganic dust in Korea. Coronary artery calcium score (CACS) examination was conducted in 115 subjects from April-July 2010. Of the total subjects, 90 participants completed pulmonary function tests in triplicate. Of these, we excluded 7 participants who had history of cardiovascular disease, such as myocardial infarction, stroke, cerebral hemorrhage, or any prior history of malignancy. Finally, 83 subjects were suitable for analyses. Of a total of 83 participants, 18 subjects had a CACS value >100, while 65 subjects had a CACS value ≤100. After adjustment for age, an occupational history of mining, pneumoconiosis profusion type, and conventional risk factors for cardiovascular disease, an inverse correlation was found between a CACS value >100 and FVC% predicted in our logistical regression model (odds ratio, 8. 94; 95% confidence interval, 1. 48-53. 97). Overall, our findings indicate an inverse relationship between restrictive lung disease and atherosclerosis risk in workers exposed to inorganic dust.

Original languageEnglish
Pages (from-to)139-142
Number of pages4
JournalToxicology and Environmental Health Sciences
Volume4
Issue number3
DOIs
Publication statusPublished - 2012 Dec 1

Fingerprint

Dust
Coronary Vessels
Calcium
Lung
Atherosclerosis
Vital Capacity
Cardiovascular Diseases
Pneumoconiosis
Pulmonary diseases
Oxidative stress
Respiratory Function Tests
Cerebral Hemorrhage
Forced Expiratory Volume
Korea
Lung Diseases
Oxidative Stress
Stroke
Odds Ratio
Myocardial Infarction
Association reactions

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Yoon, Jin Ha ; Choi, Byung Soon ; Shin, Jae Hoon ; Park, So Young ; Lee, You Lim ; Kim, Jang Young ; Lee, Won Jeong. / Association between impaired lung function and coronary artery calcium score in workers exposed to inorganic dust. In: Toxicology and Environmental Health Sciences. 2012 ; Vol. 4, No. 3. pp. 139-142.
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Association between impaired lung function and coronary artery calcium score in workers exposed to inorganic dust. / Yoon, Jin Ha; Choi, Byung Soon; Shin, Jae Hoon; Park, So Young; Lee, You Lim; Kim, Jang Young; Lee, Won Jeong.

In: Toxicology and Environmental Health Sciences, Vol. 4, No. 3, 01.12.2012, p. 139-142.

Research output: Contribution to journalArticle

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