Association between nonalcoholic fatty liver disease and carotid intima-media thickness according to the presence of metabolic syndrome

Hyeon Chang Kim, Dae Jung Kim, Kap Bum Huh

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Objective: Controversy exists as to whether the association between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis is independent of other metabolic disorders. We examined the association between NAFLD and carotid intima-media thickness (IMT) according to the presence of metabolic syndrome (MetS). Methods: A cross-sectional analysis was performed among 556 men and 465 women, ages 30-79 years. The presence of NAFLD was evaluated ultrasonographically. Carotid IMT was determined ultrasonographically by the average of the maximal IMT at each common carotid artery. Independent associations between NAFLD and IMT were assessed using multiple linear and logistic regression models, after adjusting for age, sex, waist circumference, systolic blood pressure, fasting glucose, total/HDL-cholesterol ratio, smoking, and alcohol consumption. Results: After adjusting for major risk factors, subjects with NAFLD had greater carotid IMT than subjects without NAFLD (difference 0.034 mm, p = 0.016). However, the difference in IMT was significant only in subjects with MetS (0.060 mm, p = 0.015) and not in subjects without MetS (0.015 mm, p = 0.384). Similarly, the NAFLD-associated adjusted odds ratio for increased IMT, defined as the sex-specific top quintile, was 1.63 (95% CI, 1.10-2.42) in all subjects and 2.08 (95% CI, 1.19-3.66) in subjects with MetS, but 1.18 (95% CI, 0.64-2.19) in subjects without MetS. When the analysis was performed according to the number of metabolic abnormalities, the NAFLD-IMT association was observed only in subjects with four or more abnormalities. Conclusion: These results suggest that NAFLD is independently associated with carotid atherosclerosis only in people who have multiple metabolic abnormalities.

Original languageEnglish
Pages (from-to)521-525
Number of pages5
JournalAtherosclerosis
Volume204
Issue number2
DOIs
Publication statusPublished - 2009 Jun 1

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Carotid Intima-Media Thickness
Logistic Models
Blood Pressure
Multiple Abnormalities
Non-alcoholic Fatty Liver Disease
Carotid Artery Diseases
Common Carotid Artery
Waist Circumference
Alcohol Drinking
HDL Cholesterol
Linear Models
Fasting
Atherosclerosis
Cross-Sectional Studies
Smoking
Odds Ratio
Glucose

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Association between nonalcoholic fatty liver disease and carotid intima-media thickness according to the presence of metabolic syndrome",
abstract = "Objective: Controversy exists as to whether the association between nonalcoholic fatty liver disease (NAFLD) and atherosclerosis is independent of other metabolic disorders. We examined the association between NAFLD and carotid intima-media thickness (IMT) according to the presence of metabolic syndrome (MetS). Methods: A cross-sectional analysis was performed among 556 men and 465 women, ages 30-79 years. The presence of NAFLD was evaluated ultrasonographically. Carotid IMT was determined ultrasonographically by the average of the maximal IMT at each common carotid artery. Independent associations between NAFLD and IMT were assessed using multiple linear and logistic regression models, after adjusting for age, sex, waist circumference, systolic blood pressure, fasting glucose, total/HDL-cholesterol ratio, smoking, and alcohol consumption. Results: After adjusting for major risk factors, subjects with NAFLD had greater carotid IMT than subjects without NAFLD (difference 0.034 mm, p = 0.016). However, the difference in IMT was significant only in subjects with MetS (0.060 mm, p = 0.015) and not in subjects without MetS (0.015 mm, p = 0.384). Similarly, the NAFLD-associated adjusted odds ratio for increased IMT, defined as the sex-specific top quintile, was 1.63 (95{\%} CI, 1.10-2.42) in all subjects and 2.08 (95{\%} CI, 1.19-3.66) in subjects with MetS, but 1.18 (95{\%} CI, 0.64-2.19) in subjects without MetS. When the analysis was performed according to the number of metabolic abnormalities, the NAFLD-IMT association was observed only in subjects with four or more abnormalities. Conclusion: These results suggest that NAFLD is independently associated with carotid atherosclerosis only in people who have multiple metabolic abnormalities.",
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Association between nonalcoholic fatty liver disease and carotid intima-media thickness according to the presence of metabolic syndrome. / Kim, Hyeon Chang; Kim, Dae Jung; Huh, Kap Bum.

In: Atherosclerosis, Vol. 204, No. 2, 01.06.2009, p. 521-525.

Research output: Contribution to journalArticle

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