Association Between Obesity and BRAFV600E Mutation Status in Patients with Papillary Thyroid Cancer

Jandee Lee, Cho Rok Lee, Cheol Ryong Ku, Sang Wook Kang, Jong Ju Jeong, Dong Yeob Shin, Kee Hyun Nam, Sang Geun Jung, Eunjig Lee, Woong Youn Chung, Young Suk Jo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: The prevalence of papillary thyroid cancer (PTC) is thought to be related to obesity, which affects the prognosis for PTC patients. However, the mechanisms implicated in the relationship between obesity and PTC is a matter for debate. In this study, we aimed to gain insight into the relationship between obesity and the clinicopathological features of PTC, including the BRAFV600E mutation. Methods: The medical records of 1121 PTC patients were reviewed and the relationships between anthropometric factors, biochemical parameters, and clinicopathological parameters, including BRAFV600E mutation status, were analyzed. Results: Body mass index (BMI) showed a strong association with advanced TNM stage (p < 0.001) and BRAFV600E mutation status (p = 0.008). We also found that BRAFV600E (+) patients had a higher body weight (p = 0.024) and a higher BMI (p = 0.003) than patients with BRAFV600E (−) PTC. In addition, BRAFV600E (+) PTC patients had a significantly higher incidence of extrathyroidal extension (p = 0.025) and more advanced T, N, TNM stage (p < 0.001) than BRAFV600E (−) PTC patients. Consistent with this observation, female BRAFV600E (+) PTC patients had a higher BMI (p = 0.011) and more aggressive tumor behaviors than female BRAFV600E (−) PTC patients. In multivariate analysis, BMI was persistently associated with BRAFV600E mutation in the entire cohort (odds ratio [OR] 1.387; 95 % CI 1.036–1.859; p = 0.028) and in the female subcohort (OR 1.221; 95 % CI 1.014–1.631; p = 0.046). Conclusion: The positive association between BMI and BRAFV600E supports the hypothesis that excessive bodyweight influences tumor progression.

Original languageEnglish
Pages (from-to)683-690
Number of pages8
JournalAnnals of Surgical Oncology
Volume22
DOIs
Publication statusPublished - 2015 Dec 1

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Obesity
Mutation
Body Mass Index
Odds Ratio
Papillary Thyroid cancer
Medical Records
Neoplasms
Multivariate Analysis
Body Weight
Incidence

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Lee, Jandee ; Lee, Cho Rok ; Ku, Cheol Ryong ; Kang, Sang Wook ; Jeong, Jong Ju ; Shin, Dong Yeob ; Nam, Kee Hyun ; Jung, Sang Geun ; Lee, Eunjig ; Chung, Woong Youn ; Jo, Young Suk. / Association Between Obesity and BRAFV600E Mutation Status in Patients with Papillary Thyroid Cancer. In: Annals of Surgical Oncology. 2015 ; Vol. 22. pp. 683-690.
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title = "Association Between Obesity and BRAFV600E Mutation Status in Patients with Papillary Thyroid Cancer",
abstract = "Background: The prevalence of papillary thyroid cancer (PTC) is thought to be related to obesity, which affects the prognosis for PTC patients. However, the mechanisms implicated in the relationship between obesity and PTC is a matter for debate. In this study, we aimed to gain insight into the relationship between obesity and the clinicopathological features of PTC, including the BRAFV600E mutation. Methods: The medical records of 1121 PTC patients were reviewed and the relationships between anthropometric factors, biochemical parameters, and clinicopathological parameters, including BRAFV600E mutation status, were analyzed. Results: Body mass index (BMI) showed a strong association with advanced TNM stage (p < 0.001) and BRAFV600E mutation status (p = 0.008). We also found that BRAFV600E (+) patients had a higher body weight (p = 0.024) and a higher BMI (p = 0.003) than patients with BRAFV600E (−) PTC. In addition, BRAFV600E (+) PTC patients had a significantly higher incidence of extrathyroidal extension (p = 0.025) and more advanced T, N, TNM stage (p < 0.001) than BRAFV600E (−) PTC patients. Consistent with this observation, female BRAFV600E (+) PTC patients had a higher BMI (p = 0.011) and more aggressive tumor behaviors than female BRAFV600E (−) PTC patients. In multivariate analysis, BMI was persistently associated with BRAFV600E mutation in the entire cohort (odds ratio [OR] 1.387; 95 {\%} CI 1.036–1.859; p = 0.028) and in the female subcohort (OR 1.221; 95 {\%} CI 1.014–1.631; p = 0.046). Conclusion: The positive association between BMI and BRAFV600E supports the hypothesis that excessive bodyweight influences tumor progression.",
author = "Jandee Lee and Lee, {Cho Rok} and Ku, {Cheol Ryong} and Kang, {Sang Wook} and Jeong, {Jong Ju} and Shin, {Dong Yeob} and Nam, {Kee Hyun} and Jung, {Sang Geun} and Eunjig Lee and Chung, {Woong Youn} and Jo, {Young Suk}",
year = "2015",
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Lee, J, Lee, CR, Ku, CR, Kang, SW, Jeong, JJ, Shin, DY, Nam, KH, Jung, SG, Lee, E, Chung, WY & Jo, YS 2015, 'Association Between Obesity and BRAFV600E Mutation Status in Patients with Papillary Thyroid Cancer', Annals of Surgical Oncology, vol. 22, pp. 683-690. https://doi.org/10.1245/s10434-015-4765-z

Association Between Obesity and BRAFV600E Mutation Status in Patients with Papillary Thyroid Cancer. / Lee, Jandee; Lee, Cho Rok; Ku, Cheol Ryong; Kang, Sang Wook; Jeong, Jong Ju; Shin, Dong Yeob; Nam, Kee Hyun; Jung, Sang Geun; Lee, Eunjig; Chung, Woong Youn; Jo, Young Suk.

In: Annals of Surgical Oncology, Vol. 22, 01.12.2015, p. 683-690.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association Between Obesity and BRAFV600E Mutation Status in Patients with Papillary Thyroid Cancer

AU - Lee, Jandee

AU - Lee, Cho Rok

AU - Ku, Cheol Ryong

AU - Kang, Sang Wook

AU - Jeong, Jong Ju

AU - Shin, Dong Yeob

AU - Nam, Kee Hyun

AU - Jung, Sang Geun

AU - Lee, Eunjig

AU - Chung, Woong Youn

AU - Jo, Young Suk

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Background: The prevalence of papillary thyroid cancer (PTC) is thought to be related to obesity, which affects the prognosis for PTC patients. However, the mechanisms implicated in the relationship between obesity and PTC is a matter for debate. In this study, we aimed to gain insight into the relationship between obesity and the clinicopathological features of PTC, including the BRAFV600E mutation. Methods: The medical records of 1121 PTC patients were reviewed and the relationships between anthropometric factors, biochemical parameters, and clinicopathological parameters, including BRAFV600E mutation status, were analyzed. Results: Body mass index (BMI) showed a strong association with advanced TNM stage (p < 0.001) and BRAFV600E mutation status (p = 0.008). We also found that BRAFV600E (+) patients had a higher body weight (p = 0.024) and a higher BMI (p = 0.003) than patients with BRAFV600E (−) PTC. In addition, BRAFV600E (+) PTC patients had a significantly higher incidence of extrathyroidal extension (p = 0.025) and more advanced T, N, TNM stage (p < 0.001) than BRAFV600E (−) PTC patients. Consistent with this observation, female BRAFV600E (+) PTC patients had a higher BMI (p = 0.011) and more aggressive tumor behaviors than female BRAFV600E (−) PTC patients. In multivariate analysis, BMI was persistently associated with BRAFV600E mutation in the entire cohort (odds ratio [OR] 1.387; 95 % CI 1.036–1.859; p = 0.028) and in the female subcohort (OR 1.221; 95 % CI 1.014–1.631; p = 0.046). Conclusion: The positive association between BMI and BRAFV600E supports the hypothesis that excessive bodyweight influences tumor progression.

AB - Background: The prevalence of papillary thyroid cancer (PTC) is thought to be related to obesity, which affects the prognosis for PTC patients. However, the mechanisms implicated in the relationship between obesity and PTC is a matter for debate. In this study, we aimed to gain insight into the relationship between obesity and the clinicopathological features of PTC, including the BRAFV600E mutation. Methods: The medical records of 1121 PTC patients were reviewed and the relationships between anthropometric factors, biochemical parameters, and clinicopathological parameters, including BRAFV600E mutation status, were analyzed. Results: Body mass index (BMI) showed a strong association with advanced TNM stage (p < 0.001) and BRAFV600E mutation status (p = 0.008). We also found that BRAFV600E (+) patients had a higher body weight (p = 0.024) and a higher BMI (p = 0.003) than patients with BRAFV600E (−) PTC. In addition, BRAFV600E (+) PTC patients had a significantly higher incidence of extrathyroidal extension (p = 0.025) and more advanced T, N, TNM stage (p < 0.001) than BRAFV600E (−) PTC patients. Consistent with this observation, female BRAFV600E (+) PTC patients had a higher BMI (p = 0.011) and more aggressive tumor behaviors than female BRAFV600E (−) PTC patients. In multivariate analysis, BMI was persistently associated with BRAFV600E mutation in the entire cohort (odds ratio [OR] 1.387; 95 % CI 1.036–1.859; p = 0.028) and in the female subcohort (OR 1.221; 95 % CI 1.014–1.631; p = 0.046). Conclusion: The positive association between BMI and BRAFV600E supports the hypothesis that excessive bodyweight influences tumor progression.

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U2 - 10.1245/s10434-015-4765-z

DO - 10.1245/s10434-015-4765-z

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EP - 690

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

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