Association between periodontal disease and prostate cancer: results of a 12-year longitudinal cohort study in South Korea

Jae Hong Lee, Helen Hye In Kweon, Jung Kyu Choi, Young Taek Kim, Seong Ho Choi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The incidence of prostate cancer (PC) accompanying periodontal disease (PD) is anticipated to increase due to population aging. The aim of this study was to determine the association between PD and PC using data in the National Health Insurance Service–Health Examinee Cohort (NHIS-HEC). A random stratified sample of 187,934 South Koreans was collected from the NHIS database from 2002 to 2013. We assessed the relationship between PD and PC while adjusting for potential confounding factors (sex, age, household income, insurance status, residence area, hypertension, diabetes mellitus, cerebral infarction, angina pectoris, myocardial infarction, smoking status, alcohol intake, and regular exercise). The overall incidence of PC with PD among those aged 40 years and older was 0.28% (n = 531). In the multivariate Cox proportional-hazard regression analysis with adjustment for confounding factors, PD was associated with a 14% higher risk of PC (HR = 1.14, 95% CI = 1.01–1.31, P = 0.042). The findings of this study suggest that PD is significantly and positively associated with PC. Further studies are required to identify the mechanisms underlying the links between PD and PC.

Original languageEnglish
Article number20532
JournalJournal of Cancer
Volume8
Issue number15
DOIs
Publication statusPublished - 2017

All Science Journal Classification (ASJC) codes

  • Oncology

Fingerprint Dive into the research topics of 'Association between periodontal disease and prostate cancer: results of a 12-year longitudinal cohort study in South Korea'. Together they form a unique fingerprint.

  • Cite this