Association between post-transplant uric acid level and renal allograft fibrosis: Analysis using Banff pathologic scores from renal biopsies

Deok Gie Kim, Beom Seok Kim, Hoon Young Choi, Beom Jin Lim, Kyu Ha Huh, Myoung Soo Kim, Hyeon Joo Jeong, Yu Seun Kim

Research output: Contribution to journalArticle

Abstract

Several experimental studies implicate uric acid in renal injury and fibrosis. The objective of this study was to examine the association between uric acid level and allograft fibrosis after kidney transplantation. 241 adult patients who underwent kidney transplantation between 2003 and 2014 were divided into three groups according to the sex specific tertiles of mean uric acid level within the first post-transplant year. The renal biopsies performed during 1 to 5 post-transplant year were analyzed to compare the degree of interstitial fibrosis and tubular atrophy (IF/TA). Mean interval between kidney transplantation and biopsy was similar between groups (23.7 ± 15.3 vs. 30.0 ± 18.6 vs. 27.5 ± 18.5 months, P = 0.072). The higher tertile uric acid level was, the more advanced grade of IF/TA was shown (P = 0.001). Multivariate analysis identified uric acid tertile was independent risk factor for severe IF/TA (odds ratio [95% confidence interval] was 3.16 [1.13–8.82] for tertile 2 and 3.70 [1.25–10.93] for tertile 3, versus tertile 1, respectively). Other independent factors were estimated glomerular filtration rate at 1year post-transplant (0.80 [CI 0.65–0.98]) and biopsy-proven rejection (2.34 [1.05–5.21]). Graft survival over 10 years was significantly lower in tertile 3 (P = 0.041). The results showed that higher uric acid level after kidney transplantation was associated with more severe IF/TA.

Original languageEnglish
Article number11601
JournalScientific reports
Volume8
Issue number1
DOIs
Publication statusPublished - 2018 Dec 1

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Uric Acid
Allografts
Fibrosis
Transplants
Kidney
Biopsy
Kidney Transplantation
Atrophy
Graft Survival
Glomerular Filtration Rate
Multivariate Analysis
Odds Ratio
Confidence Intervals
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • General

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Kim, Deok Gie ; Kim, Beom Seok ; Choi, Hoon Young ; Lim, Beom Jin ; Huh, Kyu Ha ; Kim, Myoung Soo ; Jeong, Hyeon Joo ; Kim, Yu Seun. / Association between post-transplant uric acid level and renal allograft fibrosis : Analysis using Banff pathologic scores from renal biopsies. In: Scientific reports. 2018 ; Vol. 8, No. 1.
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abstract = "Several experimental studies implicate uric acid in renal injury and fibrosis. The objective of this study was to examine the association between uric acid level and allograft fibrosis after kidney transplantation. 241 adult patients who underwent kidney transplantation between 2003 and 2014 were divided into three groups according to the sex specific tertiles of mean uric acid level within the first post-transplant year. The renal biopsies performed during 1 to 5 post-transplant year were analyzed to compare the degree of interstitial fibrosis and tubular atrophy (IF/TA). Mean interval between kidney transplantation and biopsy was similar between groups (23.7 ± 15.3 vs. 30.0 ± 18.6 vs. 27.5 ± 18.5 months, P = 0.072). The higher tertile uric acid level was, the more advanced grade of IF/TA was shown (P = 0.001). Multivariate analysis identified uric acid tertile was independent risk factor for severe IF/TA (odds ratio [95{\%} confidence interval] was 3.16 [1.13–8.82] for tertile 2 and 3.70 [1.25–10.93] for tertile 3, versus tertile 1, respectively). Other independent factors were estimated glomerular filtration rate at 1year post-transplant (0.80 [CI 0.65–0.98]) and biopsy-proven rejection (2.34 [1.05–5.21]). Graft survival over 10 years was significantly lower in tertile 3 (P = 0.041). The results showed that higher uric acid level after kidney transplantation was associated with more severe IF/TA.",
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Association between post-transplant uric acid level and renal allograft fibrosis : Analysis using Banff pathologic scores from renal biopsies. / Kim, Deok Gie; Kim, Beom Seok; Choi, Hoon Young; Lim, Beom Jin; Huh, Kyu Ha; Kim, Myoung Soo; Jeong, Hyeon Joo; Kim, Yu Seun.

In: Scientific reports, Vol. 8, No. 1, 11601, 01.12.2018.

Research output: Contribution to journalArticle

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AU - Kim, Deok Gie

AU - Kim, Beom Seok

AU - Choi, Hoon Young

AU - Lim, Beom Jin

AU - Huh, Kyu Ha

AU - Kim, Myoung Soo

AU - Jeong, Hyeon Joo

AU - Kim, Yu Seun

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