Association between Previous Cataract Surgery and Age-Related Macular Degeneration

Epidemiologic Survey Committee of the Korean Ophthalmological Society

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: To assess the association between age-related macular degeneration (AMD) and previous cataract surgery. Methods: We studied 17,987 randomly selected participants from the Korea National Health and Nutrition Examination Survey who were aged ≥40 years and underwent additional ophthalmologic examinations in 2008‒12. The associations between previous cataract surgery and early/late AMD were identified using multivariate logistic regression analysis of data from right or left eyes. Clustered multivariate logistic regression analysis was performed using both eyes to assess inter-eye correlation in same subject. Previous cataract surgery and cataract subtypes were based on slit-lamp examination without pupil dilation. Early and late AMD diagnoses were based on non-mydriatic digital retinal image. Results: By univariate logistic regression, both early and late AMD prevalence were higher in subjects with pseudophakia/aphakia compared to subjects with cataract as a reference group, or subjects with phakic eye (including clear lens) as a reference group. In univariate logistic regression, both early and late AMD prevalence were higher in eyes with cataract or pseudo/aphakia compared to eyes with clear lens. However, after adjusting for age with multivariate logistic regression, all statistically significant differences in AMD prevalence among subgroups disappeared. Conclusions: We found no association between the previous cataract surgery and increased early/late AMD risk in our representative, large, national patient database. This suggests that increasing age, and not cataract surgery history, is predictive of AMD risk. These findings are limited by cross-sectional study and need to be replicated by other longitudinal observational studies.

Original languageEnglish
Pages (from-to)466-473
Number of pages8
JournalSeminars in Ophthalmology
Volume32
Issue number4
DOIs
Publication statusPublished - 2017 Jul 4

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Macular Degeneration
Cataract
Logistic Models
Aphakia
Naphazoline
Lenses
Pseudophakia
Regression Analysis
Nutrition Surveys
Pupil
Korea
Observational Studies
Longitudinal Studies
Dilatation
Cross-Sectional Studies
History
Databases

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Epidemiologic Survey Committee of the Korean Ophthalmological Society. / Association between Previous Cataract Surgery and Age-Related Macular Degeneration. In: Seminars in Ophthalmology. 2017 ; Vol. 32, No. 4. pp. 466-473.
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abstract = "Purpose: To assess the association between age-related macular degeneration (AMD) and previous cataract surgery. Methods: We studied 17,987 randomly selected participants from the Korea National Health and Nutrition Examination Survey who were aged ≥40 years and underwent additional ophthalmologic examinations in 2008‒12. The associations between previous cataract surgery and early/late AMD were identified using multivariate logistic regression analysis of data from right or left eyes. Clustered multivariate logistic regression analysis was performed using both eyes to assess inter-eye correlation in same subject. Previous cataract surgery and cataract subtypes were based on slit-lamp examination without pupil dilation. Early and late AMD diagnoses were based on non-mydriatic digital retinal image. Results: By univariate logistic regression, both early and late AMD prevalence were higher in subjects with pseudophakia/aphakia compared to subjects with cataract as a reference group, or subjects with phakic eye (including clear lens) as a reference group. In univariate logistic regression, both early and late AMD prevalence were higher in eyes with cataract or pseudo/aphakia compared to eyes with clear lens. However, after adjusting for age with multivariate logistic regression, all statistically significant differences in AMD prevalence among subgroups disappeared. Conclusions: We found no association between the previous cataract surgery and increased early/late AMD risk in our representative, large, national patient database. This suggests that increasing age, and not cataract surgery history, is predictive of AMD risk. These findings are limited by cross-sectional study and need to be replicated by other longitudinal observational studies.",
author = "{Epidemiologic Survey Committee of the Korean Ophthalmological Society} and Rim, {Tyler Hyungtaek} and Lee, {Christopher Seungkyu} and Sungchul Lee and Sangah Kim and Kim, {Sung Soo}",
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Epidemiologic Survey Committee of the Korean Ophthalmological Society 2017, 'Association between Previous Cataract Surgery and Age-Related Macular Degeneration', Seminars in Ophthalmology, vol. 32, no. 4, pp. 466-473. https://doi.org/10.3109/08820538.2015.1119861

Association between Previous Cataract Surgery and Age-Related Macular Degeneration. / Epidemiologic Survey Committee of the Korean Ophthalmological Society.

In: Seminars in Ophthalmology, Vol. 32, No. 4, 04.07.2017, p. 466-473.

Research output: Contribution to journalArticle

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T1 - Association between Previous Cataract Surgery and Age-Related Macular Degeneration

AU - Epidemiologic Survey Committee of the Korean Ophthalmological Society

AU - Rim, Tyler Hyungtaek

AU - Lee, Christopher Seungkyu

AU - Lee, Sungchul

AU - Kim, Sangah

AU - Kim, Sung Soo

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N2 - Purpose: To assess the association between age-related macular degeneration (AMD) and previous cataract surgery. Methods: We studied 17,987 randomly selected participants from the Korea National Health and Nutrition Examination Survey who were aged ≥40 years and underwent additional ophthalmologic examinations in 2008‒12. The associations between previous cataract surgery and early/late AMD were identified using multivariate logistic regression analysis of data from right or left eyes. Clustered multivariate logistic regression analysis was performed using both eyes to assess inter-eye correlation in same subject. Previous cataract surgery and cataract subtypes were based on slit-lamp examination without pupil dilation. Early and late AMD diagnoses were based on non-mydriatic digital retinal image. Results: By univariate logistic regression, both early and late AMD prevalence were higher in subjects with pseudophakia/aphakia compared to subjects with cataract as a reference group, or subjects with phakic eye (including clear lens) as a reference group. In univariate logistic regression, both early and late AMD prevalence were higher in eyes with cataract or pseudo/aphakia compared to eyes with clear lens. However, after adjusting for age with multivariate logistic regression, all statistically significant differences in AMD prevalence among subgroups disappeared. Conclusions: We found no association between the previous cataract surgery and increased early/late AMD risk in our representative, large, national patient database. This suggests that increasing age, and not cataract surgery history, is predictive of AMD risk. These findings are limited by cross-sectional study and need to be replicated by other longitudinal observational studies.

AB - Purpose: To assess the association between age-related macular degeneration (AMD) and previous cataract surgery. Methods: We studied 17,987 randomly selected participants from the Korea National Health and Nutrition Examination Survey who were aged ≥40 years and underwent additional ophthalmologic examinations in 2008‒12. The associations between previous cataract surgery and early/late AMD were identified using multivariate logistic regression analysis of data from right or left eyes. Clustered multivariate logistic regression analysis was performed using both eyes to assess inter-eye correlation in same subject. Previous cataract surgery and cataract subtypes were based on slit-lamp examination without pupil dilation. Early and late AMD diagnoses were based on non-mydriatic digital retinal image. Results: By univariate logistic regression, both early and late AMD prevalence were higher in subjects with pseudophakia/aphakia compared to subjects with cataract as a reference group, or subjects with phakic eye (including clear lens) as a reference group. In univariate logistic regression, both early and late AMD prevalence were higher in eyes with cataract or pseudo/aphakia compared to eyes with clear lens. However, after adjusting for age with multivariate logistic regression, all statistically significant differences in AMD prevalence among subgroups disappeared. Conclusions: We found no association between the previous cataract surgery and increased early/late AMD risk in our representative, large, national patient database. This suggests that increasing age, and not cataract surgery history, is predictive of AMD risk. These findings are limited by cross-sectional study and need to be replicated by other longitudinal observational studies.

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