Association between risk factors for vascular dementia and Adiponectin

Juhyun Song, Won Taek Lee, Kyung Ah Park, Jongeun Lee

Research output: Contribution to journalReview article

19 Citations (Scopus)

Abstract

Vascular dementia is caused by various factors, including increased age, diabetes, hypertension, atherosclerosis, and stroke. Adiponectin is an adipokine secreted by adipose tissue. Adiponectin is widely known as a regulating factor related to cardiovascular disease and diabetes. Adiponectin plasma levels decrease with age. Decreased adiponectin increases the risk of cardiovascular disease and diabetes. Adiponectin improves hypertension and atherosclerosis by acting as a vasodilator and antiatherogenic factor. Moreover, adiponectin is involved in cognitive dysfunction via modulation of insulin signal transduction in the brain. Case-control studies demonstrate the association between low adiponectin and increased risk of stroke, hypertension, and diabetes. This review summarizes the recent findings on the association between risk factors for vascular dementia and adiponectin. To emphasize this relationship, we will discuss the importance of research regarding the role of adiponectin in vascular dementia.

Original languageEnglish
Article number261672
JournalBioMed Research International
Volume2014
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Vascular Dementia
Adiponectin
Medical problems
Hypertension
Atherosclerosis
Cardiovascular Diseases
Stroke
Association reactions
vascular factor
Signal transduction
Adipokines
Vasodilator Agents
Adipose Tissue
Case-Control Studies
Signal Transduction
Brain
Modulation
Insulin
Tissue
Plasmas

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

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abstract = "Vascular dementia is caused by various factors, including increased age, diabetes, hypertension, atherosclerosis, and stroke. Adiponectin is an adipokine secreted by adipose tissue. Adiponectin is widely known as a regulating factor related to cardiovascular disease and diabetes. Adiponectin plasma levels decrease with age. Decreased adiponectin increases the risk of cardiovascular disease and diabetes. Adiponectin improves hypertension and atherosclerosis by acting as a vasodilator and antiatherogenic factor. Moreover, adiponectin is involved in cognitive dysfunction via modulation of insulin signal transduction in the brain. Case-control studies demonstrate the association between low adiponectin and increased risk of stroke, hypertension, and diabetes. This review summarizes the recent findings on the association between risk factors for vascular dementia and adiponectin. To emphasize this relationship, we will discuss the importance of research regarding the role of adiponectin in vascular dementia.",
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Association between risk factors for vascular dementia and Adiponectin. / Song, Juhyun; Lee, Won Taek; Park, Kyung Ah; Lee, Jongeun.

In: BioMed Research International, Vol. 2014, 261672, 01.01.2014.

Research output: Contribution to journalReview article

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