Association between serum alarmin levels and disease-specific indices in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis

Sung Soo Ahn, Taejun Yoon, Jason Jungsik Song, Yong Beom Park, Sang Won Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aim: We evaluated the relationship between serum alarmin levels and disease-specific indices in patients with anti-neutrophil cytoplasmic antibody (ANCA)- associated vasculitis (AAV). Patients and Methods: Sera and data from 79 patients were utilized. For AAV-specific indices, Birmingham vasculitis activity score (BVAS), five-factor score (FFS), and vasculitis damage index (VDI) were collected and serum levels of four alarmins (hepatoma-derived growth factor, high mobility group box protein 1, S100A9, and S100A12) were measured using enzyme-linked immunosorbent assay. Associations between alarmin levels, AAV-specific indices, and inflammatory laboratory markers were assessed. Results: S100A9 levels were significantly correlated with Creactive protein levels (r=0.316, p=0.005) and S100A12 levels correlated with VDI (r=0.232, p=0.040), which was consistent in a subgroup of patients with myeloperoxidase (perinuclear)- ANCA positivity. No other associations were found between alarmin levels and BVAS, FFS, and VDI. Conclusion: The serum S100A12 level was associated with organ damage in AAV, especially in myeloperoxidase (perinuclear)-ANCApositive patients.

Original languageEnglish
Pages (from-to)1761-1768
Number of pages8
JournalIn Vivo
Volume35
Issue number3
DOIs
Publication statusPublished - 2021 May

Bibliographical note

Funding Information:
This research was supported by a faculty research grant of Yonsei University College of Medicine (6-2019-0184) and a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute, funded by the Ministry of Health and Welfare, Republic of Korea (HI14C1324).

Publisher Copyright:
© 2021 International Institute of Anticancer Research. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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