Association between Serum Immnunoglobulin E and Pterygium

A Population-Based Study from South Korea

Tae Keun Yoo, Sun Woong Kim, KyoungYul Seo

Research output: Contribution to journalArticle

Abstract

Purpose: Several studies have shown that pterygium is associated with inflammation, angiogenesis, and fibrosis. However, it should be acknowledged that not enough is known about the association between immunoglobulin E (IgE) and pterygium. The present study was conducted to test the hypothesis that elevated serum IgE is associated with a greater prevalence of pterygium. Material and Methods: A cross-sectional study was performed using data of 1,548 participants aged 30 years or older who were enrolled in the Korea National Health and Nutrition Examination Survey conducted in 2010. Multivariable logistic regression analysis was used to examine the relationship between pterygium and allergic conditions, including total serum IgE and allergen-specific serum IgE levels, after adjusting for potential confounding factors. Results: Participants with pterygium were more likely have increased IgE level (p = 0.009). After adjusting for potential confounders, the odds ratio (OR) for pterygium was greater in participants with higher total serum IgE levels (OR = 1.63; p = 0.047). Multivariable-adjusted ORs of pterygium across the tertile of increasing IgE were 1.00 (reference), 1.18, and 1.45, (P for linear trend = 0.038). Although the ORs for the upper two tertiles of cockroach and dog allergen-specific IgE were higher than those for the lowest tertile, allergen-specific serum IgE showed no clear association with pterygium. Conclusions: Increased total serum IgE concentration is independently related to pterygium after adjusting for confounding factors. To the best of our knowledge, this study is the first research that reveals an association between serum IgE and pterygium.

Original languageEnglish
Pages (from-to)1090-1096
Number of pages7
JournalCurrent Eye Research
Volume43
Issue number9
DOIs
Publication statusPublished - 2018 Sep 2

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Pterygium
Republic of Korea
Immunoglobulin E
Serum
Population
Allergens
Odds Ratio
Cockroaches
Nutrition Surveys
Korea
Fibrosis
Cross-Sectional Studies
Logistic Models
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

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title = "Association between Serum Immnunoglobulin E and Pterygium: A Population-Based Study from South Korea",
abstract = "Purpose: Several studies have shown that pterygium is associated with inflammation, angiogenesis, and fibrosis. However, it should be acknowledged that not enough is known about the association between immunoglobulin E (IgE) and pterygium. The present study was conducted to test the hypothesis that elevated serum IgE is associated with a greater prevalence of pterygium. Material and Methods: A cross-sectional study was performed using data of 1,548 participants aged 30 years or older who were enrolled in the Korea National Health and Nutrition Examination Survey conducted in 2010. Multivariable logistic regression analysis was used to examine the relationship between pterygium and allergic conditions, including total serum IgE and allergen-specific serum IgE levels, after adjusting for potential confounding factors. Results: Participants with pterygium were more likely have increased IgE level (p = 0.009). After adjusting for potential confounders, the odds ratio (OR) for pterygium was greater in participants with higher total serum IgE levels (OR = 1.63; p = 0.047). Multivariable-adjusted ORs of pterygium across the tertile of increasing IgE were 1.00 (reference), 1.18, and 1.45, (P for linear trend = 0.038). Although the ORs for the upper two tertiles of cockroach and dog allergen-specific IgE were higher than those for the lowest tertile, allergen-specific serum IgE showed no clear association with pterygium. Conclusions: Increased total serum IgE concentration is independently related to pterygium after adjusting for confounding factors. To the best of our knowledge, this study is the first research that reveals an association between serum IgE and pterygium.",
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Association between Serum Immnunoglobulin E and Pterygium : A Population-Based Study from South Korea. / Yoo, Tae Keun; Kim, Sun Woong; Seo, KyoungYul.

In: Current Eye Research, Vol. 43, No. 9, 02.09.2018, p. 1090-1096.

Research output: Contribution to journalArticle

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