Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus: A Meta-analysis

Jiwon M. Lee, Andreas Kronbichler, Se Jin Park, Seong Heon Kim, Kyoung Hee Han, Hee Gyung Kang, Il Soo Ha, Hae Il Cheong, Ki Hwan Kim, Gaeun Kim, Dong Soo Kim, Hyun Wook Chae, Chul Ho Lee, Keum Hwa Lee, Jae Il Shin

Research output: Contribution to journalArticle

Abstract

Introduction: Matrix metalloproteinase (MMP) is an emerging disease marker in rheumatic diseases. This is a meta-analysis aimed at systematically reviewing association between serum MMP-3 levels and systematic lupus erythematosus (SLE) activity, which sought to raise interest in MMP-3 as a putative biomarker. Methods: We conducted a meta-analysis of serum MMP-3 levels in patients with SLE and controls. We performed a PubMed search, EMBASE search, and forward search of the retrieved articles published until Oct. 1, 2018. In addition to this, we included data from a case-control study on a national pediatric SLE cohort, in which serum MMP-3 levels were measured in 11 SLE patients and 9 controls (unpublished). Subgroup analyses based on gender and disease activity were performed. Results: A total of 662 cases and 771 controls including 651 patients and 762 controls from 11 publications were studied. We observed significantly higher MMP-3 levels in SLE patients compared to healthy controls (P < 0.001, Hedges' g: 2.104, 95% CI 1.426-2.782). In subgroup analyses, we found a significant elevation of MMP-3 in the patients with nephritis compared to those without (P = 0.006, Hedges' g: 0.611, 95% CI 0.611-1.704). This finding was consistent between patients with persistent proteinuria and those without (P = 0.023, Hedges' g: 1.535, 95% CI 0.207-2.862). Meta-analysis showed no association between MMP-3 levels and gender or anti-double strand DNA antibody titer. Conclusions: Our meta-analysis demonstrated significantly higher MMP-3 levels in SLE patients than in controls and in patients with renal involvement than in those without.

Original languageEnglish
Number of pages1
JournalDisease markers
Volume2019
DOIs
Publication statusPublished - 2019 Jan 1

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Matrix Metalloproteinase 3
Systemic Lupus Erythematosus
Meta-Analysis
Serum
Association reactions
Pediatrics
Nephritis
Biomarkers
Rheumatic Diseases
Matrix Metalloproteinases
Proteinuria
PubMed
Publications
Case-Control Studies
Kidney
Antibodies
DNA

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Lee, Jiwon M. ; Kronbichler, Andreas ; Park, Se Jin ; Kim, Seong Heon ; Han, Kyoung Hee ; Kang, Hee Gyung ; Ha, Il Soo ; Cheong, Hae Il ; Kim, Ki Hwan ; Kim, Gaeun ; Kim, Dong Soo ; Chae, Hyun Wook ; Lee, Chul Ho ; Lee, Keum Hwa ; Shin, Jae Il. / Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus : A Meta-analysis. In: Disease markers. 2019 ; Vol. 2019.
@article{73e920ac28324ae8acb0b1aa17cb14a8,
title = "Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus: A Meta-analysis",
abstract = "Introduction: Matrix metalloproteinase (MMP) is an emerging disease marker in rheumatic diseases. This is a meta-analysis aimed at systematically reviewing association between serum MMP-3 levels and systematic lupus erythematosus (SLE) activity, which sought to raise interest in MMP-3 as a putative biomarker. Methods: We conducted a meta-analysis of serum MMP-3 levels in patients with SLE and controls. We performed a PubMed search, EMBASE search, and forward search of the retrieved articles published until Oct. 1, 2018. In addition to this, we included data from a case-control study on a national pediatric SLE cohort, in which serum MMP-3 levels were measured in 11 SLE patients and 9 controls (unpublished). Subgroup analyses based on gender and disease activity were performed. Results: A total of 662 cases and 771 controls including 651 patients and 762 controls from 11 publications were studied. We observed significantly higher MMP-3 levels in SLE patients compared to healthy controls (P < 0.001, Hedges' g: 2.104, 95{\%} CI 1.426-2.782). In subgroup analyses, we found a significant elevation of MMP-3 in the patients with nephritis compared to those without (P = 0.006, Hedges' g: 0.611, 95{\%} CI 0.611-1.704). This finding was consistent between patients with persistent proteinuria and those without (P = 0.023, Hedges' g: 1.535, 95{\%} CI 0.207-2.862). Meta-analysis showed no association between MMP-3 levels and gender or anti-double strand DNA antibody titer. Conclusions: Our meta-analysis demonstrated significantly higher MMP-3 levels in SLE patients than in controls and in patients with renal involvement than in those without.",
author = "Lee, {Jiwon M.} and Andreas Kronbichler and Park, {Se Jin} and Kim, {Seong Heon} and Han, {Kyoung Hee} and Kang, {Hee Gyung} and Ha, {Il Soo} and Cheong, {Hae Il} and Kim, {Ki Hwan} and Gaeun Kim and Kim, {Dong Soo} and Chae, {Hyun Wook} and Lee, {Chul Ho} and Lee, {Keum Hwa} and Shin, {Jae Il}",
year = "2019",
month = "1",
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Lee, JM, Kronbichler, A, Park, SJ, Kim, SH, Han, KH, Kang, HG, Ha, IS, Cheong, HI, Kim, KH, Kim, G, Kim, DS, Chae, HW, Lee, CH, Lee, KH & Shin, JI 2019, 'Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus: A Meta-analysis', Disease markers, vol. 2019. https://doi.org/10.1155/2019/9796735

Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus : A Meta-analysis. / Lee, Jiwon M.; Kronbichler, Andreas; Park, Se Jin; Kim, Seong Heon; Han, Kyoung Hee; Kang, Hee Gyung; Ha, Il Soo; Cheong, Hae Il; Kim, Ki Hwan; Kim, Gaeun; Kim, Dong Soo; Chae, Hyun Wook; Lee, Chul Ho; Lee, Keum Hwa; Shin, Jae Il.

In: Disease markers, Vol. 2019, 01.01.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between Serum Matrix Metalloproteinase- (MMP-) 3 Levels and Systemic Lupus Erythematosus

T2 - A Meta-analysis

AU - Lee, Jiwon M.

AU - Kronbichler, Andreas

AU - Park, Se Jin

AU - Kim, Seong Heon

AU - Han, Kyoung Hee

AU - Kang, Hee Gyung

AU - Ha, Il Soo

AU - Cheong, Hae Il

AU - Kim, Ki Hwan

AU - Kim, Gaeun

AU - Kim, Dong Soo

AU - Chae, Hyun Wook

AU - Lee, Chul Ho

AU - Lee, Keum Hwa

AU - Shin, Jae Il

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Introduction: Matrix metalloproteinase (MMP) is an emerging disease marker in rheumatic diseases. This is a meta-analysis aimed at systematically reviewing association between serum MMP-3 levels and systematic lupus erythematosus (SLE) activity, which sought to raise interest in MMP-3 as a putative biomarker. Methods: We conducted a meta-analysis of serum MMP-3 levels in patients with SLE and controls. We performed a PubMed search, EMBASE search, and forward search of the retrieved articles published until Oct. 1, 2018. In addition to this, we included data from a case-control study on a national pediatric SLE cohort, in which serum MMP-3 levels were measured in 11 SLE patients and 9 controls (unpublished). Subgroup analyses based on gender and disease activity were performed. Results: A total of 662 cases and 771 controls including 651 patients and 762 controls from 11 publications were studied. We observed significantly higher MMP-3 levels in SLE patients compared to healthy controls (P < 0.001, Hedges' g: 2.104, 95% CI 1.426-2.782). In subgroup analyses, we found a significant elevation of MMP-3 in the patients with nephritis compared to those without (P = 0.006, Hedges' g: 0.611, 95% CI 0.611-1.704). This finding was consistent between patients with persistent proteinuria and those without (P = 0.023, Hedges' g: 1.535, 95% CI 0.207-2.862). Meta-analysis showed no association between MMP-3 levels and gender or anti-double strand DNA antibody titer. Conclusions: Our meta-analysis demonstrated significantly higher MMP-3 levels in SLE patients than in controls and in patients with renal involvement than in those without.

AB - Introduction: Matrix metalloproteinase (MMP) is an emerging disease marker in rheumatic diseases. This is a meta-analysis aimed at systematically reviewing association between serum MMP-3 levels and systematic lupus erythematosus (SLE) activity, which sought to raise interest in MMP-3 as a putative biomarker. Methods: We conducted a meta-analysis of serum MMP-3 levels in patients with SLE and controls. We performed a PubMed search, EMBASE search, and forward search of the retrieved articles published until Oct. 1, 2018. In addition to this, we included data from a case-control study on a national pediatric SLE cohort, in which serum MMP-3 levels were measured in 11 SLE patients and 9 controls (unpublished). Subgroup analyses based on gender and disease activity were performed. Results: A total of 662 cases and 771 controls including 651 patients and 762 controls from 11 publications were studied. We observed significantly higher MMP-3 levels in SLE patients compared to healthy controls (P < 0.001, Hedges' g: 2.104, 95% CI 1.426-2.782). In subgroup analyses, we found a significant elevation of MMP-3 in the patients with nephritis compared to those without (P = 0.006, Hedges' g: 0.611, 95% CI 0.611-1.704). This finding was consistent between patients with persistent proteinuria and those without (P = 0.023, Hedges' g: 1.535, 95% CI 0.207-2.862). Meta-analysis showed no association between MMP-3 levels and gender or anti-double strand DNA antibody titer. Conclusions: Our meta-analysis demonstrated significantly higher MMP-3 levels in SLE patients than in controls and in patients with renal involvement than in those without.

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U2 - 10.1155/2019/9796735

DO - 10.1155/2019/9796735

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