Background: Resistin is an adipocytokine belonging to the family of cysteine rich secretory proteins. We sought to determine if a correlation between resistin levels and carotid atherosclerosis exists in hypertensive patients. Methods: This study consisted of 307 treated hypertensive patients. Subjects were grouped into tertiles according to their resistin level. Results: Carotid intima media thickness (IMT) was significantly highest in the third tertile. The first tertile had a mean carotid IMT and a mean of maximum carotid IMT of 0.63 ± 0.08 and 0.81 ± 0.10 mm, respectively. The 2nd tertile had measurements of 0.63 ± 0.08 and 0.81 ± 0.12 mm, and the 3rd tertile 0.67 ± 0.12 and 0.86 ± 0.11 for the same parameters. (p = 0.002). Resistin levels were independently associated with the carotid IMT (mean carotid IMT: R2 = 0.159, p < 0.001 and mean of maximum carotid IMT: R2 = 0.162, p < 0.001) after controlling for age, gender, HDL cholesterol, triglyceride, LDL cholesterol, smoking and DM. The tertile level of resistin was significantly associated with (odds ratio = 3.097, p = 0.004) risk of coronary artery disease after controlling for age, gender, HDL cholesterol, triglyceride, LDL cholesterol, smoking, DM and carotid IMT. Conclusion: Serum resistin is independently associated with increasing carotid IMT in treated hypertensive patients.
Bibliographical noteFunding Information:
The authors thank biostatistician, Chanmi Park for her invaluable assistance in statistical analysis and Woo Chul Chang for his assistance in the laboratory assays. This work was supported by grant (A000385) from the Ministry of Health and Welfare, Republic of Korea, and by a grant of the Seoul R&BD Program, Republic of Korea (10526).
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine