Association between serum total bilirubin level and leukoaraiosis in Korean adults

Byoung Jin Park, Jae Yong Shim, Hye Ree Lee, Hee Taik Kang, Jung Hyun Lee, Yongjae Lee

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objectives: Leukoaraiosis is associated with cerebrovascular microangiopathy. Increasing evidence suggests that bilirubin is a potent cytoprotectant in the development of cardiovascular diseases. This study aimed to determine whether total bilirubin is related to leukoaraiosis. Methods: We examined the relationship of total bilirubin with leukoaraiosis in 1005 Korean adults. The odds ratios for leukoaraiosis were calculated using multivariate logistic regression across serum total bilirubin tertiles. Results: In comparison with the subjects in the reference group (total bilirubin: 15-26μmol/L), the odds ratio (95% CI) for leukoaraiosis in the 3rd tertile (total bilirubin ≤ 10 μmol/L) was 5.50 (1.24-24.40) in women after adjusting for confounding variables. However, this inverse association between serum total bilirubin and the prevalence of leukoaraiosis was not found in men after adjusting for the same co-variables. Conclusion: Total bilirubin level was inversely associated with leukoaraiosis regardless of classical cardiovascular risk factors in Korean women.

Original languageEnglish
Pages (from-to)289-292
Number of pages4
JournalClinical Biochemistry
Volume45
Issue number4-5
DOIs
Publication statusPublished - 2012 Jan 1

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Leukoaraiosis
Bilirubin
Serum
Odds Ratio
Confounding Factors (Epidemiology)
Logistics
Cardiovascular Diseases
Logistic Models

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry

Cite this

Park, Byoung Jin ; Shim, Jae Yong ; Lee, Hye Ree ; Kang, Hee Taik ; Lee, Jung Hyun ; Lee, Yongjae. / Association between serum total bilirubin level and leukoaraiosis in Korean adults. In: Clinical Biochemistry. 2012 ; Vol. 45, No. 4-5. pp. 289-292.
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Association between serum total bilirubin level and leukoaraiosis in Korean adults. / Park, Byoung Jin; Shim, Jae Yong; Lee, Hye Ree; Kang, Hee Taik; Lee, Jung Hyun; Lee, Yongjae.

In: Clinical Biochemistry, Vol. 45, No. 4-5, 01.01.2012, p. 289-292.

Research output: Contribution to journalArticle

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AU - Lee, Yongjae

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