Abstract
Objectives: Leukoaraiosis is associated with cerebrovascular microangiopathy. Increasing evidence suggests that bilirubin is a potent cytoprotectant in the development of cardiovascular diseases. This study aimed to determine whether total bilirubin is related to leukoaraiosis. Methods: We examined the relationship of total bilirubin with leukoaraiosis in 1005 Korean adults. The odds ratios for leukoaraiosis were calculated using multivariate logistic regression across serum total bilirubin tertiles. Results: In comparison with the subjects in the reference group (total bilirubin: 15-26μmol/L), the odds ratio (95% CI) for leukoaraiosis in the 3rd tertile (total bilirubin ≤ 10 μmol/L) was 5.50 (1.24-24.40) in women after adjusting for confounding variables. However, this inverse association between serum total bilirubin and the prevalence of leukoaraiosis was not found in men after adjusting for the same co-variables. Conclusion: Total bilirubin level was inversely associated with leukoaraiosis regardless of classical cardiovascular risk factors in Korean women.
| Original language | English |
|---|---|
| Pages (from-to) | 289-292 |
| Number of pages | 4 |
| Journal | Clinical Biochemistry |
| Volume | 45 |
| Issue number | 4-5 |
| DOIs | |
| Publication status | Published - 2012 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Clinical Biochemistry
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Association between serum total bilirubin level and leukoaraiosis in Korean adults. / Park, Byoung Jin; Shim, Jae Yong; Lee, Hye Ree; Kang, Hee Taik; Lee, Jung Hyun; Lee, Yongjae.
In: Clinical Biochemistry, Vol. 45, No. 4-5, 01.01.2012, p. 289-292.Research output: Contribution to journal › Article
TY - JOUR
T1 - Association between serum total bilirubin level and leukoaraiosis in Korean adults
AU - Park, Byoung Jin
AU - Shim, Jae Yong
AU - Lee, Hye Ree
AU - Kang, Hee Taik
AU - Lee, Jung Hyun
AU - Lee, Yongjae
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Objectives: Leukoaraiosis is associated with cerebrovascular microangiopathy. Increasing evidence suggests that bilirubin is a potent cytoprotectant in the development of cardiovascular diseases. This study aimed to determine whether total bilirubin is related to leukoaraiosis. Methods: We examined the relationship of total bilirubin with leukoaraiosis in 1005 Korean adults. The odds ratios for leukoaraiosis were calculated using multivariate logistic regression across serum total bilirubin tertiles. Results: In comparison with the subjects in the reference group (total bilirubin: 15-26μmol/L), the odds ratio (95% CI) for leukoaraiosis in the 3rd tertile (total bilirubin ≤ 10 μmol/L) was 5.50 (1.24-24.40) in women after adjusting for confounding variables. However, this inverse association between serum total bilirubin and the prevalence of leukoaraiosis was not found in men after adjusting for the same co-variables. Conclusion: Total bilirubin level was inversely associated with leukoaraiosis regardless of classical cardiovascular risk factors in Korean women.
AB - Objectives: Leukoaraiosis is associated with cerebrovascular microangiopathy. Increasing evidence suggests that bilirubin is a potent cytoprotectant in the development of cardiovascular diseases. This study aimed to determine whether total bilirubin is related to leukoaraiosis. Methods: We examined the relationship of total bilirubin with leukoaraiosis in 1005 Korean adults. The odds ratios for leukoaraiosis were calculated using multivariate logistic regression across serum total bilirubin tertiles. Results: In comparison with the subjects in the reference group (total bilirubin: 15-26μmol/L), the odds ratio (95% CI) for leukoaraiosis in the 3rd tertile (total bilirubin ≤ 10 μmol/L) was 5.50 (1.24-24.40) in women after adjusting for confounding variables. However, this inverse association between serum total bilirubin and the prevalence of leukoaraiosis was not found in men after adjusting for the same co-variables. Conclusion: Total bilirubin level was inversely associated with leukoaraiosis regardless of classical cardiovascular risk factors in Korean women.
UR - http://www.scopus.com/inward/record.url?scp=84862804281&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862804281&partnerID=8YFLogxK
U2 - 10.1016/j.clinbiochem.2011.12.023
DO - 10.1016/j.clinbiochem.2011.12.023
M3 - Article
C2 - 22245549
AN - SCOPUS:84862804281
VL - 45
SP - 289
EP - 292
JO - Clinical Biochemistry
JF - Clinical Biochemistry
SN - 0009-9120
IS - 4-5
ER -