Association between serum uric acid level and metabolic syndrome

Ju Mi Lee, HyeonChang Kim, Hye Min Cho, Sun Min Oh, Dong Phil Choi, Il Suh

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Objectives: Serum uric acid levels have been reported to be associated with a variety of cardiovascular conditions. However, the direct association between uric acid levels and metabolic syndrome remains controversial. Thus, we evaluated the association of serum uric acid levels and metabolic syndrome in a community-based cohort study in Korea. Methods: We performed cross-sectional analysis of baseline data of 889 males and 1491 females (aged 38 to 87) who participated in baseline examinations of the Korean Genome and Epidemiology Study: Kanghwa study. Blood samples were collected after at least an 8 hour fast. Uric acid quartiles were defined as follows: <4.8, 4.8-<5.6, 5.6-<6.5, ≥6.5 mg/dL in males; and <3.8, 3.8-<4.3, 4.3 -<5.1, ≥5.1 mg/dL in females. Metabolic syndrome was defined by the National Cholesterol Education Program Adult Treatment Panel III Criteria with adjusted waist circumference cutoffs (90 cm for males; 80 cm for females). The association between serum uric acid quartiles and metabolic syndrome was assessed using multivariate logistic regression. Results: The odds ratio for having metabolic syndrome in the highest versus lowest quartiles of serum uric acid levels was 2.67 (95% confidence interval [CI], 1.60 to 4.46) in males and 2.14 (95% CI, 1.50 to 3.05) in females after adjusting for age, smoking, alcohol intake, body mass index, total cholesterol, HbA1c, albumin, γ-glutamyltransferase, blood urea nitrogen, and log C-reactive protein. The number of metabolic abnormalities also increased gradually with increasing serum uric acid levels (adjusted p for trend <0.001 in both sexes). Conclusions: Higher serum uric acid levels are positively associated with the presence of metabolic syndrome in Korean males and females.

Original languageEnglish
Pages (from-to)181-187
Number of pages7
JournalJournal of Preventive Medicine and Public Health
Volume45
Issue number3
DOIs
Publication statusPublished - 2012 May 1

Fingerprint

Uric Acid
Serum
Cholesterol
Confidence Intervals
Blood Urea Nitrogen
Waist Circumference
Korea
C-Reactive Protein
Albumins
Epidemiology
Body Mass Index
Cohort Studies
Cross-Sectional Studies
Logistic Models
Smoking
Odds Ratio
Alcohols
Genome
Education

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health

Cite this

Lee, Ju Mi ; Kim, HyeonChang ; Cho, Hye Min ; Oh, Sun Min ; Choi, Dong Phil ; Suh, Il. / Association between serum uric acid level and metabolic syndrome. In: Journal of Preventive Medicine and Public Health. 2012 ; Vol. 45, No. 3. pp. 181-187.
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Association between serum uric acid level and metabolic syndrome. / Lee, Ju Mi; Kim, HyeonChang; Cho, Hye Min; Oh, Sun Min; Choi, Dong Phil; Suh, Il.

In: Journal of Preventive Medicine and Public Health, Vol. 45, No. 3, 01.05.2012, p. 181-187.

Research output: Contribution to journalArticle

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