Association between sex hormone levels and leukoaraiosis (LA) in older Korean men

Byoung Jin Park, Jae Yong Shim, Yongjae Lee, Jung Hyun Lee, Hye Ree Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

LA, altered white matter signal intensities seen on MR brain scans, has been shown to be associated with cerebrovascular risk factors and microangiopathy. Although the cerebrovascular system is also a target for sex hormones, little is known about the association between the two. In this study, we investigated the association between male sex hormone levels and LA in old men by examining free testosterone index (FTI), total testosterone, sex hormone-binding globulin (SHBG), and LA in 342 Korean men (aged 50-80 years). The odds ratios (ORs) for LA were calculated using multivariate logistic regression. The ORs (95% CIs) for LA were 1.06 (1.01-1.10) for FTI, 1.01 (0.93-1.10) for total testosterone, and 0.97 (0.94-1.01) for SHBG after adjusting for age, smoking status, alcohol intake, regular exercise, BMI, mean arterial blood pressure, resting heart rate, white blood cell counts, fasting plasma glucose, total cholesterol, triglyceride, HDL-cholesterol, hypertension medications, diabetes medications, and hyperlipidemia medications. The results of this study indicate that high FTI is independently associated with greater prevalence of LA in older men. Accordingly, a higher FTI may be an additional surrogate marker in assessing LA.

Original languageEnglish
JournalArchives of Gerontology and Geriatrics
Volume54
Issue number2
DOIs
Publication statusPublished - 2012 Mar 1

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Leukoaraiosis
Gonadal Steroid Hormones
Testosterone
medication
Sex Hormone-Binding Globulin
hypertension
Arterial Pressure
chronic illness
smoking
Odds Ratio
brain
logistics
alcohol
regression
Hyperlipidemias
Leukocyte Count
HDL Cholesterol
Fasting
Triglycerides
Biomarkers

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Ageing
  • Gerontology
  • Geriatrics and Gerontology

Cite this

Park, Byoung Jin ; Shim, Jae Yong ; Lee, Yongjae ; Lee, Jung Hyun ; Lee, Hye Ree. / Association between sex hormone levels and leukoaraiosis (LA) in older Korean men. In: Archives of Gerontology and Geriatrics. 2012 ; Vol. 54, No. 2.
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Association between sex hormone levels and leukoaraiosis (LA) in older Korean men. / Park, Byoung Jin; Shim, Jae Yong; Lee, Yongjae; Lee, Jung Hyun; Lee, Hye Ree.

In: Archives of Gerontology and Geriatrics, Vol. 54, No. 2, 01.03.2012.

Research output: Contribution to journalArticle

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