Abstract
LA, altered white matter signal intensities seen on MR brain scans, has been shown to be associated with cerebrovascular risk factors and microangiopathy. Although the cerebrovascular system is also a target for sex hormones, little is known about the association between the two. In this study, we investigated the association between male sex hormone levels and LA in old men by examining free testosterone index (FTI), total testosterone, sex hormone-binding globulin (SHBG), and LA in 342 Korean men (aged 50-80 years). The odds ratios (ORs) for LA were calculated using multivariate logistic regression. The ORs (95% CIs) for LA were 1.06 (1.01-1.10) for FTI, 1.01 (0.93-1.10) for total testosterone, and 0.97 (0.94-1.01) for SHBG after adjusting for age, smoking status, alcohol intake, regular exercise, BMI, mean arterial blood pressure, resting heart rate, white blood cell counts, fasting plasma glucose, total cholesterol, triglyceride, HDL-cholesterol, hypertension medications, diabetes medications, and hyperlipidemia medications. The results of this study indicate that high FTI is independently associated with greater prevalence of LA in older men. Accordingly, a higher FTI may be an additional surrogate marker in assessing LA.
| Original language | English |
|---|---|
| Journal | Archives of Gerontology and Geriatrics |
| Volume | 54 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2012 Mar 1 |
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All Science Journal Classification (ASJC) codes
- Health(social science)
- Ageing
- Gerontology
- Geriatrics and Gerontology
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Association between sex hormone levels and leukoaraiosis (LA) in older Korean men. / Park, Byoung Jin; Shim, Jae Yong; Lee, Yongjae; Lee, Jung Hyun; Lee, Hye Ree.
In: Archives of Gerontology and Geriatrics, Vol. 54, No. 2, 01.03.2012.Research output: Contribution to journal › Article
TY - JOUR
T1 - Association between sex hormone levels and leukoaraiosis (LA) in older Korean men
AU - Park, Byoung Jin
AU - Shim, Jae Yong
AU - Lee, Yongjae
AU - Lee, Jung Hyun
AU - Lee, Hye Ree
PY - 2012/3/1
Y1 - 2012/3/1
N2 - LA, altered white matter signal intensities seen on MR brain scans, has been shown to be associated with cerebrovascular risk factors and microangiopathy. Although the cerebrovascular system is also a target for sex hormones, little is known about the association between the two. In this study, we investigated the association between male sex hormone levels and LA in old men by examining free testosterone index (FTI), total testosterone, sex hormone-binding globulin (SHBG), and LA in 342 Korean men (aged 50-80 years). The odds ratios (ORs) for LA were calculated using multivariate logistic regression. The ORs (95% CIs) for LA were 1.06 (1.01-1.10) for FTI, 1.01 (0.93-1.10) for total testosterone, and 0.97 (0.94-1.01) for SHBG after adjusting for age, smoking status, alcohol intake, regular exercise, BMI, mean arterial blood pressure, resting heart rate, white blood cell counts, fasting plasma glucose, total cholesterol, triglyceride, HDL-cholesterol, hypertension medications, diabetes medications, and hyperlipidemia medications. The results of this study indicate that high FTI is independently associated with greater prevalence of LA in older men. Accordingly, a higher FTI may be an additional surrogate marker in assessing LA.
AB - LA, altered white matter signal intensities seen on MR brain scans, has been shown to be associated with cerebrovascular risk factors and microangiopathy. Although the cerebrovascular system is also a target for sex hormones, little is known about the association between the two. In this study, we investigated the association between male sex hormone levels and LA in old men by examining free testosterone index (FTI), total testosterone, sex hormone-binding globulin (SHBG), and LA in 342 Korean men (aged 50-80 years). The odds ratios (ORs) for LA were calculated using multivariate logistic regression. The ORs (95% CIs) for LA were 1.06 (1.01-1.10) for FTI, 1.01 (0.93-1.10) for total testosterone, and 0.97 (0.94-1.01) for SHBG after adjusting for age, smoking status, alcohol intake, regular exercise, BMI, mean arterial blood pressure, resting heart rate, white blood cell counts, fasting plasma glucose, total cholesterol, triglyceride, HDL-cholesterol, hypertension medications, diabetes medications, and hyperlipidemia medications. The results of this study indicate that high FTI is independently associated with greater prevalence of LA in older men. Accordingly, a higher FTI may be an additional surrogate marker in assessing LA.
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UR - http://www.scopus.com/inward/citedby.url?scp=84857058153&partnerID=8YFLogxK
U2 - 10.1016/j.archger.2011.06.035
DO - 10.1016/j.archger.2011.06.035
M3 - Article
VL - 54
JO - Archives of Gerontology and Geriatrics
JF - Archives of Gerontology and Geriatrics
SN - 0167-4943
IS - 2
ER -