Association between the ratio of insulin-like growth factor-I to insulin-like growth factor binding protein-3 and inflammation in incident automated peritoneal dialysis patients

Mi Jung Lee, Dong Ho Shin, Kwang Il Ko, Hyang Mo Koo, Chan Ho Kim, Fa Mee Doh, Hyung Jung Oh, SeungHyeok Han, TaeHyun Yoo, Beom Seok Kim, Shin-Wook Kang, Kyu Hun Choi

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: The insulin-like growth factor (IGF) system is known to be associated with inflammation in various populations. However, the association between the IGF system and inflammation has not previously been investigated in automated peritoneal dialysis (APD) patients. Therefore, the aim of this study was to investigate whether the IGF system correlates with inflammation in APD patients. Methods: We prospectively determined IGF-I activity, the ratio of serum IGF-I concentrations to those of IGF binding protein-3 (IGFBP-3), and inflammatory markers at initiation of APD and after 6. months of follow-up in 21 incident APD patients. Results: The mean age was 55.2±13.1. years, and 11 patients (52.3%) were male. Continuous cyclic PD (CCPD) was performed in 11 patients, and nocturnal intermittent PD (NIPD) in 10 patients. The mean value of IGF-I/IGFBP-3 was 0.21±0.13. At baseline, IGF-I/IGFBP-3 was negatively correlated with high-sensitivity C-reactive protein (hs-CRP) (r = -0.27, P = 0.032) and interleukin-6 (IL-6) (r = -0.19, P = 0.046) concentrations. After 6. months, IGF-I/IGFBP-3 (P = 0.048) had decreased significantly, while the hs-CRP (P = 0.036) increased significantly in the CCPD group. However, there were no significant changes in IGF-I/IGFBP-3 (P = 0.59) and hs-CRP (P = 0.14) during 6. months in the NIPD group. Furthermore, compared with the NIPD group, IGF-I/IGFBP-3 (P = 0.041) decreased greater, whereas hs-CRP (P = 0.048) concentrations increased greater in the CCPD group. Conclusions: The IGF system was significantly associated with inflammatory markers in incident APD patients, and different APD modalities modulate the IGF system and inflammation.

Original languageEnglish
Pages (from-to)170-174
Number of pages5
JournalGrowth Hormone and IGF Research
Volume23
Issue number5
DOIs
Publication statusPublished - 2013 Oct 1

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Insulin-Like Growth Factor Binding Protein 3
Peritoneal Dialysis
Insulin-Like Growth Factor I
Somatomedins
Inflammation
C-Reactive Protein
Interleukin-6
Serum
Population

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Lee, Mi Jung ; Shin, Dong Ho ; Ko, Kwang Il ; Koo, Hyang Mo ; Kim, Chan Ho ; Doh, Fa Mee ; Oh, Hyung Jung ; Han, SeungHyeok ; Yoo, TaeHyun ; Kim, Beom Seok ; Kang, Shin-Wook ; Choi, Kyu Hun. / Association between the ratio of insulin-like growth factor-I to insulin-like growth factor binding protein-3 and inflammation in incident automated peritoneal dialysis patients. In: Growth Hormone and IGF Research. 2013 ; Vol. 23, No. 5. pp. 170-174.
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abstract = "Background: The insulin-like growth factor (IGF) system is known to be associated with inflammation in various populations. However, the association between the IGF system and inflammation has not previously been investigated in automated peritoneal dialysis (APD) patients. Therefore, the aim of this study was to investigate whether the IGF system correlates with inflammation in APD patients. Methods: We prospectively determined IGF-I activity, the ratio of serum IGF-I concentrations to those of IGF binding protein-3 (IGFBP-3), and inflammatory markers at initiation of APD and after 6. months of follow-up in 21 incident APD patients. Results: The mean age was 55.2±13.1. years, and 11 patients (52.3{\%}) were male. Continuous cyclic PD (CCPD) was performed in 11 patients, and nocturnal intermittent PD (NIPD) in 10 patients. The mean value of IGF-I/IGFBP-3 was 0.21±0.13. At baseline, IGF-I/IGFBP-3 was negatively correlated with high-sensitivity C-reactive protein (hs-CRP) (r = -0.27, P = 0.032) and interleukin-6 (IL-6) (r = -0.19, P = 0.046) concentrations. After 6. months, IGF-I/IGFBP-3 (P = 0.048) had decreased significantly, while the hs-CRP (P = 0.036) increased significantly in the CCPD group. However, there were no significant changes in IGF-I/IGFBP-3 (P = 0.59) and hs-CRP (P = 0.14) during 6. months in the NIPD group. Furthermore, compared with the NIPD group, IGF-I/IGFBP-3 (P = 0.041) decreased greater, whereas hs-CRP (P = 0.048) concentrations increased greater in the CCPD group. Conclusions: The IGF system was significantly associated with inflammatory markers in incident APD patients, and different APD modalities modulate the IGF system and inflammation.",
author = "Lee, {Mi Jung} and Shin, {Dong Ho} and Ko, {Kwang Il} and Koo, {Hyang Mo} and Kim, {Chan Ho} and Doh, {Fa Mee} and Oh, {Hyung Jung} and SeungHyeok Han and TaeHyun Yoo and Kim, {Beom Seok} and Shin-Wook Kang and Choi, {Kyu Hun}",
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Association between the ratio of insulin-like growth factor-I to insulin-like growth factor binding protein-3 and inflammation in incident automated peritoneal dialysis patients. / Lee, Mi Jung; Shin, Dong Ho; Ko, Kwang Il; Koo, Hyang Mo; Kim, Chan Ho; Doh, Fa Mee; Oh, Hyung Jung; Han, SeungHyeok; Yoo, TaeHyun; Kim, Beom Seok; Kang, Shin-Wook; Choi, Kyu Hun.

In: Growth Hormone and IGF Research, Vol. 23, No. 5, 01.10.2013, p. 170-174.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between the ratio of insulin-like growth factor-I to insulin-like growth factor binding protein-3 and inflammation in incident automated peritoneal dialysis patients

AU - Lee, Mi Jung

AU - Shin, Dong Ho

AU - Ko, Kwang Il

AU - Koo, Hyang Mo

AU - Kim, Chan Ho

AU - Doh, Fa Mee

AU - Oh, Hyung Jung

AU - Han, SeungHyeok

AU - Yoo, TaeHyun

AU - Kim, Beom Seok

AU - Kang, Shin-Wook

AU - Choi, Kyu Hun

PY - 2013/10/1

Y1 - 2013/10/1

N2 - Background: The insulin-like growth factor (IGF) system is known to be associated with inflammation in various populations. However, the association between the IGF system and inflammation has not previously been investigated in automated peritoneal dialysis (APD) patients. Therefore, the aim of this study was to investigate whether the IGF system correlates with inflammation in APD patients. Methods: We prospectively determined IGF-I activity, the ratio of serum IGF-I concentrations to those of IGF binding protein-3 (IGFBP-3), and inflammatory markers at initiation of APD and after 6. months of follow-up in 21 incident APD patients. Results: The mean age was 55.2±13.1. years, and 11 patients (52.3%) were male. Continuous cyclic PD (CCPD) was performed in 11 patients, and nocturnal intermittent PD (NIPD) in 10 patients. The mean value of IGF-I/IGFBP-3 was 0.21±0.13. At baseline, IGF-I/IGFBP-3 was negatively correlated with high-sensitivity C-reactive protein (hs-CRP) (r = -0.27, P = 0.032) and interleukin-6 (IL-6) (r = -0.19, P = 0.046) concentrations. After 6. months, IGF-I/IGFBP-3 (P = 0.048) had decreased significantly, while the hs-CRP (P = 0.036) increased significantly in the CCPD group. However, there were no significant changes in IGF-I/IGFBP-3 (P = 0.59) and hs-CRP (P = 0.14) during 6. months in the NIPD group. Furthermore, compared with the NIPD group, IGF-I/IGFBP-3 (P = 0.041) decreased greater, whereas hs-CRP (P = 0.048) concentrations increased greater in the CCPD group. Conclusions: The IGF system was significantly associated with inflammatory markers in incident APD patients, and different APD modalities modulate the IGF system and inflammation.

AB - Background: The insulin-like growth factor (IGF) system is known to be associated with inflammation in various populations. However, the association between the IGF system and inflammation has not previously been investigated in automated peritoneal dialysis (APD) patients. Therefore, the aim of this study was to investigate whether the IGF system correlates with inflammation in APD patients. Methods: We prospectively determined IGF-I activity, the ratio of serum IGF-I concentrations to those of IGF binding protein-3 (IGFBP-3), and inflammatory markers at initiation of APD and after 6. months of follow-up in 21 incident APD patients. Results: The mean age was 55.2±13.1. years, and 11 patients (52.3%) were male. Continuous cyclic PD (CCPD) was performed in 11 patients, and nocturnal intermittent PD (NIPD) in 10 patients. The mean value of IGF-I/IGFBP-3 was 0.21±0.13. At baseline, IGF-I/IGFBP-3 was negatively correlated with high-sensitivity C-reactive protein (hs-CRP) (r = -0.27, P = 0.032) and interleukin-6 (IL-6) (r = -0.19, P = 0.046) concentrations. After 6. months, IGF-I/IGFBP-3 (P = 0.048) had decreased significantly, while the hs-CRP (P = 0.036) increased significantly in the CCPD group. However, there were no significant changes in IGF-I/IGFBP-3 (P = 0.59) and hs-CRP (P = 0.14) during 6. months in the NIPD group. Furthermore, compared with the NIPD group, IGF-I/IGFBP-3 (P = 0.041) decreased greater, whereas hs-CRP (P = 0.048) concentrations increased greater in the CCPD group. Conclusions: The IGF system was significantly associated with inflammatory markers in incident APD patients, and different APD modalities modulate the IGF system and inflammation.

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U2 - 10.1016/j.ghir.2013.06.004

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