Association between the ratio of triglycerides to high-density lipoprotein cholesterol and chronic kidney disease in Korean adults: The 2005 Korean National health and nutrition examination survey

Hee Taik Kang, Jae Yong Shim, Yong Jae Lee, Jung Eun Lee, John A. Linton, Jong Koo Kim, Hye Ree Lee

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Abstract

Background: The ratio of triglycerides (TG, mg/dl) to high-density lipoprotein cholesterol (HDL-C, mg/dl) is a reliable indicator of insulin resistance and atherosclerotic diseases. The purpose of this study was to examine the association between TG/HDL-C and chronic kidney disease (CKD) in a nationally representative sample of Korean adults. Methods: This cross-sectional study included 5,503 subjects (≥19 years of age) who participated in the 2005 Korean National Health and Nutrition Examination Survey. CKD was defined as an estimated glomerular filtration rate (eGFR) below 60 ml/min/1.73 m 2 as calculated by the abbreviated formula from the Modification of Diet in Renal Disease study. Results: The overall prevalence of CKD in our sample was 9.0%. eGFR was negatively correlated with logarithm-transformed TG/HDL-C in Pearson's correlation. The prevalence of CKD in increasing TG/HDL-C quintiles was 4.4, 6.6, 9.5, 11.9, and 12.8%. In comparison with the lowest quintile of TG/HDL-C (<1.38), the odds ratio (95% confidence interval) for CKD in the highest quintile of TG/HDL-C (≥4.50) was 2.15 (1.38-3.37), after adjustment for multiple covariates (p value for trend = 0.036). Conclusions: TG/HDL-C was independently associated with increased prevalence of CKD in a sample of Korean adults.

Original languageEnglish
Pages (from-to)173-179
Number of pages7
JournalKidney and Blood Pressure Research
Volume34
Issue number3
DOIs
Publication statusPublished - 2011 May 1

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All Science Journal Classification (ASJC) codes

  • Nephrology
  • Cardiology and Cardiovascular Medicine

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