Association between the ratio of triglycerides to high-density lipoprotein cholesterol and chronic kidney disease in Korean adults

The 2005 Korean National health and nutrition examination survey

Hee Taik Kang, Jae Yong Shim, Yongjae Lee, Jung Eun Lee, John A. Linton, Jong Koo Kim, Hye Ree Lee

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: The ratio of triglycerides (TG, mg/dl) to high-density lipoprotein cholesterol (HDL-C, mg/dl) is a reliable indicator of insulin resistance and atherosclerotic diseases. The purpose of this study was to examine the association between TG/HDL-C and chronic kidney disease (CKD) in a nationally representative sample of Korean adults. Methods: This cross-sectional study included 5,503 subjects (≥19 years of age) who participated in the 2005 Korean National Health and Nutrition Examination Survey. CKD was defined as an estimated glomerular filtration rate (eGFR) below 60 ml/min/1.73 m 2 as calculated by the abbreviated formula from the Modification of Diet in Renal Disease study. Results: The overall prevalence of CKD in our sample was 9.0%. eGFR was negatively correlated with logarithm-transformed TG/HDL-C in Pearson's correlation. The prevalence of CKD in increasing TG/HDL-C quintiles was 4.4, 6.6, 9.5, 11.9, and 12.8%. In comparison with the lowest quintile of TG/HDL-C (<1.38), the odds ratio (95% confidence interval) for CKD in the highest quintile of TG/HDL-C (≥4.50) was 2.15 (1.38-3.37), after adjustment for multiple covariates (p value for trend = 0.036). Conclusions: TG/HDL-C was independently associated with increased prevalence of CKD in a sample of Korean adults.

Original languageEnglish
Pages (from-to)173-179
Number of pages7
JournalKidney and Blood Pressure Research
Volume34
Issue number3
DOIs
Publication statusPublished - 2011 May 1

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Nutrition Surveys
Chronic Renal Insufficiency
HDL Cholesterol
Triglycerides
Glomerular Filtration Rate
Formulated Food
Insulin Resistance
Cross-Sectional Studies
Odds Ratio
Confidence Intervals
Kidney

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Nephrology

Cite this

@article{d060514544c64cca9b342eb409a1e8e1,
title = "Association between the ratio of triglycerides to high-density lipoprotein cholesterol and chronic kidney disease in Korean adults: The 2005 Korean National health and nutrition examination survey",
abstract = "Background: The ratio of triglycerides (TG, mg/dl) to high-density lipoprotein cholesterol (HDL-C, mg/dl) is a reliable indicator of insulin resistance and atherosclerotic diseases. The purpose of this study was to examine the association between TG/HDL-C and chronic kidney disease (CKD) in a nationally representative sample of Korean adults. Methods: This cross-sectional study included 5,503 subjects (≥19 years of age) who participated in the 2005 Korean National Health and Nutrition Examination Survey. CKD was defined as an estimated glomerular filtration rate (eGFR) below 60 ml/min/1.73 m 2 as calculated by the abbreviated formula from the Modification of Diet in Renal Disease study. Results: The overall prevalence of CKD in our sample was 9.0{\%}. eGFR was negatively correlated with logarithm-transformed TG/HDL-C in Pearson's correlation. The prevalence of CKD in increasing TG/HDL-C quintiles was 4.4, 6.6, 9.5, 11.9, and 12.8{\%}. In comparison with the lowest quintile of TG/HDL-C (<1.38), the odds ratio (95{\%} confidence interval) for CKD in the highest quintile of TG/HDL-C (≥4.50) was 2.15 (1.38-3.37), after adjustment for multiple covariates (p value for trend = 0.036). Conclusions: TG/HDL-C was independently associated with increased prevalence of CKD in a sample of Korean adults.",
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Association between the ratio of triglycerides to high-density lipoprotein cholesterol and chronic kidney disease in Korean adults : The 2005 Korean National health and nutrition examination survey. / Kang, Hee Taik; Shim, Jae Yong; Lee, Yongjae; Lee, Jung Eun; Linton, John A.; Kim, Jong Koo; Lee, Hye Ree.

In: Kidney and Blood Pressure Research, Vol. 34, No. 3, 01.05.2011, p. 173-179.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between the ratio of triglycerides to high-density lipoprotein cholesterol and chronic kidney disease in Korean adults

T2 - The 2005 Korean National health and nutrition examination survey

AU - Kang, Hee Taik

AU - Shim, Jae Yong

AU - Lee, Yongjae

AU - Lee, Jung Eun

AU - Linton, John A.

AU - Kim, Jong Koo

AU - Lee, Hye Ree

PY - 2011/5/1

Y1 - 2011/5/1

N2 - Background: The ratio of triglycerides (TG, mg/dl) to high-density lipoprotein cholesterol (HDL-C, mg/dl) is a reliable indicator of insulin resistance and atherosclerotic diseases. The purpose of this study was to examine the association between TG/HDL-C and chronic kidney disease (CKD) in a nationally representative sample of Korean adults. Methods: This cross-sectional study included 5,503 subjects (≥19 years of age) who participated in the 2005 Korean National Health and Nutrition Examination Survey. CKD was defined as an estimated glomerular filtration rate (eGFR) below 60 ml/min/1.73 m 2 as calculated by the abbreviated formula from the Modification of Diet in Renal Disease study. Results: The overall prevalence of CKD in our sample was 9.0%. eGFR was negatively correlated with logarithm-transformed TG/HDL-C in Pearson's correlation. The prevalence of CKD in increasing TG/HDL-C quintiles was 4.4, 6.6, 9.5, 11.9, and 12.8%. In comparison with the lowest quintile of TG/HDL-C (<1.38), the odds ratio (95% confidence interval) for CKD in the highest quintile of TG/HDL-C (≥4.50) was 2.15 (1.38-3.37), after adjustment for multiple covariates (p value for trend = 0.036). Conclusions: TG/HDL-C was independently associated with increased prevalence of CKD in a sample of Korean adults.

AB - Background: The ratio of triglycerides (TG, mg/dl) to high-density lipoprotein cholesterol (HDL-C, mg/dl) is a reliable indicator of insulin resistance and atherosclerotic diseases. The purpose of this study was to examine the association between TG/HDL-C and chronic kidney disease (CKD) in a nationally representative sample of Korean adults. Methods: This cross-sectional study included 5,503 subjects (≥19 years of age) who participated in the 2005 Korean National Health and Nutrition Examination Survey. CKD was defined as an estimated glomerular filtration rate (eGFR) below 60 ml/min/1.73 m 2 as calculated by the abbreviated formula from the Modification of Diet in Renal Disease study. Results: The overall prevalence of CKD in our sample was 9.0%. eGFR was negatively correlated with logarithm-transformed TG/HDL-C in Pearson's correlation. The prevalence of CKD in increasing TG/HDL-C quintiles was 4.4, 6.6, 9.5, 11.9, and 12.8%. In comparison with the lowest quintile of TG/HDL-C (<1.38), the odds ratio (95% confidence interval) for CKD in the highest quintile of TG/HDL-C (≥4.50) was 2.15 (1.38-3.37), after adjustment for multiple covariates (p value for trend = 0.036). Conclusions: TG/HDL-C was independently associated with increased prevalence of CKD in a sample of Korean adults.

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SN - 1420-4096

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