Association between the triglyceride to high-density lipoprotein cholesterol ratio and insulin resistance in Korean adolescents: A nationwide population-based study

Jae Min Park, Jee Yon Lee, Jae June Dong, Duk Chul Lee, Yongjae Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Studies have suggested the triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) as a surrogate marker of insulin resistance. However, few studies have examined the association between TG/HDL-C and insulin resistance in the general adolescent population. This study aimed to examine the association between TG/HDL-C and insulin resistance in a nationally representative sample of Korean adolescents. Methods: A total of 2649 participants aged 12-18 years were selected from the 2007 to 2010 Korean National Health and Nutrition Examination Survey (KNHANES). Insulin resistance was defined as the homeostatic model assessment of insulin resistance (HOMA-IR) values greater than the 80th percentile. Results: The mean values of most cardiometabolic variables increased proportionally with TG/HDL-C quartiles. Compared to individuals in the lowest TG/HDL-C quartile, the odds ratio for insulin resistance for individuals in the highest quartile was 2.91 in boys and 2.38 in girls after adjusting for confounding variables. Conclusions: This study suggests that TG/HDL-C could be a convenient marker for identifying Korean adolescents with insulin resistance.

Original languageEnglish
Pages (from-to)1259-1265
Number of pages7
JournalJournal of Pediatric Endocrinology and Metabolism
Volume29
Issue number11
DOIs
Publication statusPublished - 2016 Nov 1

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HDL Cholesterol
Insulin Resistance
Triglycerides
Population
Confounding Factors (Epidemiology)
Nutrition Surveys
Biomarkers
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

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abstract = "Background: Studies have suggested the triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) as a surrogate marker of insulin resistance. However, few studies have examined the association between TG/HDL-C and insulin resistance in the general adolescent population. This study aimed to examine the association between TG/HDL-C and insulin resistance in a nationally representative sample of Korean adolescents. Methods: A total of 2649 participants aged 12-18 years were selected from the 2007 to 2010 Korean National Health and Nutrition Examination Survey (KNHANES). Insulin resistance was defined as the homeostatic model assessment of insulin resistance (HOMA-IR) values greater than the 80th percentile. Results: The mean values of most cardiometabolic variables increased proportionally with TG/HDL-C quartiles. Compared to individuals in the lowest TG/HDL-C quartile, the odds ratio for insulin resistance for individuals in the highest quartile was 2.91 in boys and 2.38 in girls after adjusting for confounding variables. Conclusions: This study suggests that TG/HDL-C could be a convenient marker for identifying Korean adolescents with insulin resistance.",
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Association between the triglyceride to high-density lipoprotein cholesterol ratio and insulin resistance in Korean adolescents : A nationwide population-based study. / Park, Jae Min; Lee, Jee Yon; Dong, Jae June; Lee, Duk Chul; Lee, Yongjae.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 29, No. 11, 01.11.2016, p. 1259-1265.

Research output: Contribution to journalArticle

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AU - Lee, Duk Chul

AU - Lee, Yongjae

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