Association between the triglyceride to high-density lipoprotein cholesterol ratio and insulin resistance in Korean adolescents: A nationwide population-based study

Jae Min Park, Jee Yon Lee, Jae June Dong, Duk Chul Lee, Yong Jae Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Studies have suggested the triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C) as a surrogate marker of insulin resistance. However, few studies have examined the association between TG/HDL-C and insulin resistance in the general adolescent population. This study aimed to examine the association between TG/HDL-C and insulin resistance in a nationally representative sample of Korean adolescents. Methods: A total of 2649 participants aged 12-18 years were selected from the 2007 to 2010 Korean National Health and Nutrition Examination Survey (KNHANES). Insulin resistance was defined as the homeostatic model assessment of insulin resistance (HOMA-IR) values greater than the 80th percentile. Results: The mean values of most cardiometabolic variables increased proportionally with TG/HDL-C quartiles. Compared to individuals in the lowest TG/HDL-C quartile, the odds ratio for insulin resistance for individuals in the highest quartile was 2.91 in boys and 2.38 in girls after adjusting for confounding variables. Conclusions: This study suggests that TG/HDL-C could be a convenient marker for identifying Korean adolescents with insulin resistance.

Original languageEnglish
Pages (from-to)1259-1265
Number of pages7
JournalJournal of Pediatric Endocrinology and Metabolism
Volume29
Issue number11
DOIs
Publication statusPublished - 2016 Nov 1

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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