Association between vitamin D deficiency and anemia in patients with end-stage renal disease

A cross-sectional study

Yung Ly Kim, Hyunwook Kim, Young Eun Kwon, Dong Ryeol Ryu, Mi Jung Lee, Kyung Sook Park, Han Jak Ryu, Jung Tak Park, Hyung Jung Oh, SeungHyeok Han, TaeHyun Yoo, Shin-Wook Kang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: Despite new treatment strategies, anemia remains the most prevalent complication in patients with end-stage renal disease (ESRD). We investigated whether 25-hydroxyvitamin D [25(OH)D3] deficiency was associated with anemia in ESRD patients. Materials and Methods: We reviewed the medical records of 410 ESRD patients who had undergone renal transplantation (RTx) at Yonsei University Health System and who had 25(OH)D3 levels measured at the time of RTx. Patients were divided into two groups based on baseline 25(OH)D3 concentrations: group 1, 25(OH)D3 levels <10 ng/mL; and group 2, 25(OH)D3 levels ≥10 ng/mL. Results: Using multivariate regression models, 25(OH)D3, age, and erythrocyte-stimulating agent (ESA) dose were found to be significantly associated with hemoglobin (Hb) levels [25(OH)D3: β=0.263, p<0.001; age: β=0.122, p=0.010; ESA dose: β=-0.069, p=0.005]. In addition, logistic regression analysis revealed that patients in group 1 had a significantly higher risk for developing anemia (Hb level <10 g/dL) compared to group 2 patients, even after adjusting for potential risk factors for anemia (odds ratio=3.857; confidence interval=1.091–13.632; p=0.036). Conclusion: 25(OH)D3 deficiency was significantly associated with anemia in patients with ESRD. Randomized controlled trials are needed to determine whether vitamin D supplementation can improve anemia in these patients.

Original languageEnglish
Pages (from-to)1159-1164
Number of pages6
JournalYonsei medical journal
Volume57
Issue number5
DOIs
Publication statusPublished - 2016 Sep 1

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Vitamin D Deficiency
Chronic Kidney Failure
Anemia
Cross-Sectional Studies
Hemoglobins
Erythrocytes
Vitamin D
Kidney Transplantation
Medical Records
Randomized Controlled Trials
Logistic Models
Odds Ratio
Regression Analysis
Confidence Intervals
Health

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kim, Yung Ly ; Kim, Hyunwook ; Kwon, Young Eun ; Ryu, Dong Ryeol ; Lee, Mi Jung ; Park, Kyung Sook ; Ryu, Han Jak ; Park, Jung Tak ; Oh, Hyung Jung ; Han, SeungHyeok ; Yoo, TaeHyun ; Kang, Shin-Wook. / Association between vitamin D deficiency and anemia in patients with end-stage renal disease : A cross-sectional study. In: Yonsei medical journal. 2016 ; Vol. 57, No. 5. pp. 1159-1164.
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abstract = "Purpose: Despite new treatment strategies, anemia remains the most prevalent complication in patients with end-stage renal disease (ESRD). We investigated whether 25-hydroxyvitamin D [25(OH)D3] deficiency was associated with anemia in ESRD patients. Materials and Methods: We reviewed the medical records of 410 ESRD patients who had undergone renal transplantation (RTx) at Yonsei University Health System and who had 25(OH)D3 levels measured at the time of RTx. Patients were divided into two groups based on baseline 25(OH)D3 concentrations: group 1, 25(OH)D3 levels <10 ng/mL; and group 2, 25(OH)D3 levels ≥10 ng/mL. Results: Using multivariate regression models, 25(OH)D3, age, and erythrocyte-stimulating agent (ESA) dose were found to be significantly associated with hemoglobin (Hb) levels [25(OH)D3: β=0.263, p<0.001; age: β=0.122, p=0.010; ESA dose: β=-0.069, p=0.005]. In addition, logistic regression analysis revealed that patients in group 1 had a significantly higher risk for developing anemia (Hb level <10 g/dL) compared to group 2 patients, even after adjusting for potential risk factors for anemia (odds ratio=3.857; confidence interval=1.091–13.632; p=0.036). Conclusion: 25(OH)D3 deficiency was significantly associated with anemia in patients with ESRD. Randomized controlled trials are needed to determine whether vitamin D supplementation can improve anemia in these patients.",
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Association between vitamin D deficiency and anemia in patients with end-stage renal disease : A cross-sectional study. / Kim, Yung Ly; Kim, Hyunwook; Kwon, Young Eun; Ryu, Dong Ryeol; Lee, Mi Jung; Park, Kyung Sook; Ryu, Han Jak; Park, Jung Tak; Oh, Hyung Jung; Han, SeungHyeok; Yoo, TaeHyun; Kang, Shin-Wook.

In: Yonsei medical journal, Vol. 57, No. 5, 01.09.2016, p. 1159-1164.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between vitamin D deficiency and anemia in patients with end-stage renal disease

T2 - A cross-sectional study

AU - Kim, Yung Ly

AU - Kim, Hyunwook

AU - Kwon, Young Eun

AU - Ryu, Dong Ryeol

AU - Lee, Mi Jung

AU - Park, Kyung Sook

AU - Ryu, Han Jak

AU - Park, Jung Tak

AU - Oh, Hyung Jung

AU - Han, SeungHyeok

AU - Yoo, TaeHyun

AU - Kang, Shin-Wook

PY - 2016/9/1

Y1 - 2016/9/1

N2 - Purpose: Despite new treatment strategies, anemia remains the most prevalent complication in patients with end-stage renal disease (ESRD). We investigated whether 25-hydroxyvitamin D [25(OH)D3] deficiency was associated with anemia in ESRD patients. Materials and Methods: We reviewed the medical records of 410 ESRD patients who had undergone renal transplantation (RTx) at Yonsei University Health System and who had 25(OH)D3 levels measured at the time of RTx. Patients were divided into two groups based on baseline 25(OH)D3 concentrations: group 1, 25(OH)D3 levels <10 ng/mL; and group 2, 25(OH)D3 levels ≥10 ng/mL. Results: Using multivariate regression models, 25(OH)D3, age, and erythrocyte-stimulating agent (ESA) dose were found to be significantly associated with hemoglobin (Hb) levels [25(OH)D3: β=0.263, p<0.001; age: β=0.122, p=0.010; ESA dose: β=-0.069, p=0.005]. In addition, logistic regression analysis revealed that patients in group 1 had a significantly higher risk for developing anemia (Hb level <10 g/dL) compared to group 2 patients, even after adjusting for potential risk factors for anemia (odds ratio=3.857; confidence interval=1.091–13.632; p=0.036). Conclusion: 25(OH)D3 deficiency was significantly associated with anemia in patients with ESRD. Randomized controlled trials are needed to determine whether vitamin D supplementation can improve anemia in these patients.

AB - Purpose: Despite new treatment strategies, anemia remains the most prevalent complication in patients with end-stage renal disease (ESRD). We investigated whether 25-hydroxyvitamin D [25(OH)D3] deficiency was associated with anemia in ESRD patients. Materials and Methods: We reviewed the medical records of 410 ESRD patients who had undergone renal transplantation (RTx) at Yonsei University Health System and who had 25(OH)D3 levels measured at the time of RTx. Patients were divided into two groups based on baseline 25(OH)D3 concentrations: group 1, 25(OH)D3 levels <10 ng/mL; and group 2, 25(OH)D3 levels ≥10 ng/mL. Results: Using multivariate regression models, 25(OH)D3, age, and erythrocyte-stimulating agent (ESA) dose were found to be significantly associated with hemoglobin (Hb) levels [25(OH)D3: β=0.263, p<0.001; age: β=0.122, p=0.010; ESA dose: β=-0.069, p=0.005]. In addition, logistic regression analysis revealed that patients in group 1 had a significantly higher risk for developing anemia (Hb level <10 g/dL) compared to group 2 patients, even after adjusting for potential risk factors for anemia (odds ratio=3.857; confidence interval=1.091–13.632; p=0.036). Conclusion: 25(OH)D3 deficiency was significantly associated with anemia in patients with ESRD. Randomized controlled trials are needed to determine whether vitamin D supplementation can improve anemia in these patients.

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