Association between Vitamin D deficiency and health-related quality of life in patients with chronic kidney disease from the KNOW-CKD study

Representatives of the KNOW-CKD Investigator Group

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Vitamin D deficiency is a growing health problem in both the general population and in patients with chronic kidney disease (CKD). However, the relationship between serum 25-hydroxyvitamin D levels and health-related quality of life in CKD is not well established. This study examined the association between vitamin D deficiency and quality of life in pre-dialysis CKD patients. Serum 25-hydroxyvitamin D levels and the Korean version of the Kidney Disease Quality of Life short form were obtained for 1844 pre-dialysis CKD patients in the prospective KoreaN cohort Study for Outcomes in patients With Chronic Kidney Disease (KNOW-CKD). The baseline estimated glomerular filtration rate was 50.26 ± 0.71 mL/min/1.73 m2. We identified 1294 (70.2%) patients with vitamin D deficiency, defined as a 25-hydroxyvitamin D level < 20 ng/ml. The scores of the kidney disease component summary, physical component summary, and mental component summary in the vitamin D deficiency group were significantly lower compared to the scores of those without vitamin D deficiency. The serum 25-hydroxyvitamin D level was independently associated with the kidney disease component summary and mental component summary scores (β = 0.147, p = 0.003 and β = 0.151, p = 0.047). In conclusion, there was a significant association between serum 25-hydroxyvitamin D levels and kidney disease component summary and mental component summary scores in pre-dialysis CKD patients.

Original languageEnglish
Article numbere0174282
JournalPloS one
Volume12
Issue number4
DOIs
Publication statusPublished - 2017 Apr 1

Fingerprint

vitamin D deficiency
Vitamin D Deficiency
kidney diseases
Chronic Renal Insufficiency
quality of life
Vitamin D
Quality of Life
Health
Kidney Diseases
Dialysis
Serum
dialysis
Glomerular Filtration Rate
Health Status
Cohort Studies
glomerular filtration rate
25-hydroxyvitamin D
Medical problems
cohort studies
Population

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

@article{06e7f499d81748a792b16257a4c2593f,
title = "Association between Vitamin D deficiency and health-related quality of life in patients with chronic kidney disease from the KNOW-CKD study",
abstract = "Vitamin D deficiency is a growing health problem in both the general population and in patients with chronic kidney disease (CKD). However, the relationship between serum 25-hydroxyvitamin D levels and health-related quality of life in CKD is not well established. This study examined the association between vitamin D deficiency and quality of life in pre-dialysis CKD patients. Serum 25-hydroxyvitamin D levels and the Korean version of the Kidney Disease Quality of Life short form were obtained for 1844 pre-dialysis CKD patients in the prospective KoreaN cohort Study for Outcomes in patients With Chronic Kidney Disease (KNOW-CKD). The baseline estimated glomerular filtration rate was 50.26 ± 0.71 mL/min/1.73 m2. We identified 1294 (70.2{\%}) patients with vitamin D deficiency, defined as a 25-hydroxyvitamin D level < 20 ng/ml. The scores of the kidney disease component summary, physical component summary, and mental component summary in the vitamin D deficiency group were significantly lower compared to the scores of those without vitamin D deficiency. The serum 25-hydroxyvitamin D level was independently associated with the kidney disease component summary and mental component summary scores (β = 0.147, p = 0.003 and β = 0.151, p = 0.047). In conclusion, there was a significant association between serum 25-hydroxyvitamin D levels and kidney disease component summary and mental component summary scores in pre-dialysis CKD patients.",
author = "{Representatives of the KNOW-CKD Investigator Group} and Oh, {Tae Ryom} and Kim, {Chang Seong} and Bae, {Eun Hui} and Ma, {Seong Kwon} and SeungHyeok Han and Sung, {Su Ah} and Kyubeck Lee and Oh, {Kook Hwan} and Curie Ahn and Kim, {Soo Wan} and Oh, {Kook Hwan} and Hajeong Lee and Seungmi Lee and Jiseon Kim and Aram Lee and Chae, {Dong Wan} and Baek, {Seon Ha} and Cho, {Hyun Jin} and Choi, {Kyu Hun} and TaeHyun Yoo and Yu, {Mi Hyun} and Lee, {Kyu Beck} and Hyun, {Young Youl} and Kim, {Yong Soo} and Ahn, {Min Jung} and Wookyung Chung and Jung, {Ji Yong} and Youkyoung Jang and Park, {Ji Hye} and Suah Sung and Lee, {Sung Woo} and Yoo, {Min A.} and Kang, {Yong Un} and Kim, {Ha Yeon} and Lee, {Ji Seon} and Kim, {Yeong Hoon} and Kang, {Sun Woo} and Kim, {Tae Hee} and Son, {A. Jin} and Oh, {Yun Kyu} and Park, {Byung Joo} and Park, {Sue K.} and Lee, {Ju Yeon} and Joongyub Lee and Dayeon Nam and Soohee Kang and Heejung Ahn and Seo, {Dong Hee} and Cho, {Dae Yeon} and Yeong, {Go Un}",
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month = "4",
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Association between Vitamin D deficiency and health-related quality of life in patients with chronic kidney disease from the KNOW-CKD study. / Representatives of the KNOW-CKD Investigator Group.

In: PloS one, Vol. 12, No. 4, e0174282, 01.04.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between Vitamin D deficiency and health-related quality of life in patients with chronic kidney disease from the KNOW-CKD study

AU - Representatives of the KNOW-CKD Investigator Group

AU - Oh, Tae Ryom

AU - Kim, Chang Seong

AU - Bae, Eun Hui

AU - Ma, Seong Kwon

AU - Han, SeungHyeok

AU - Sung, Su Ah

AU - Lee, Kyubeck

AU - Oh, Kook Hwan

AU - Ahn, Curie

AU - Kim, Soo Wan

AU - Oh, Kook Hwan

AU - Lee, Hajeong

AU - Lee, Seungmi

AU - Kim, Jiseon

AU - Lee, Aram

AU - Chae, Dong Wan

AU - Baek, Seon Ha

AU - Cho, Hyun Jin

AU - Choi, Kyu Hun

AU - Yoo, TaeHyun

AU - Yu, Mi Hyun

AU - Lee, Kyu Beck

AU - Hyun, Young Youl

AU - Kim, Yong Soo

AU - Ahn, Min Jung

AU - Chung, Wookyung

AU - Jung, Ji Yong

AU - Jang, Youkyoung

AU - Park, Ji Hye

AU - Sung, Suah

AU - Lee, Sung Woo

AU - Yoo, Min A.

AU - Kang, Yong Un

AU - Kim, Ha Yeon

AU - Lee, Ji Seon

AU - Kim, Yeong Hoon

AU - Kang, Sun Woo

AU - Kim, Tae Hee

AU - Son, A. Jin

AU - Oh, Yun Kyu

AU - Park, Byung Joo

AU - Park, Sue K.

AU - Lee, Ju Yeon

AU - Lee, Joongyub

AU - Nam, Dayeon

AU - Kang, Soohee

AU - Ahn, Heejung

AU - Seo, Dong Hee

AU - Cho, Dae Yeon

AU - Yeong, Go Un

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Vitamin D deficiency is a growing health problem in both the general population and in patients with chronic kidney disease (CKD). However, the relationship between serum 25-hydroxyvitamin D levels and health-related quality of life in CKD is not well established. This study examined the association between vitamin D deficiency and quality of life in pre-dialysis CKD patients. Serum 25-hydroxyvitamin D levels and the Korean version of the Kidney Disease Quality of Life short form were obtained for 1844 pre-dialysis CKD patients in the prospective KoreaN cohort Study for Outcomes in patients With Chronic Kidney Disease (KNOW-CKD). The baseline estimated glomerular filtration rate was 50.26 ± 0.71 mL/min/1.73 m2. We identified 1294 (70.2%) patients with vitamin D deficiency, defined as a 25-hydroxyvitamin D level < 20 ng/ml. The scores of the kidney disease component summary, physical component summary, and mental component summary in the vitamin D deficiency group were significantly lower compared to the scores of those without vitamin D deficiency. The serum 25-hydroxyvitamin D level was independently associated with the kidney disease component summary and mental component summary scores (β = 0.147, p = 0.003 and β = 0.151, p = 0.047). In conclusion, there was a significant association between serum 25-hydroxyvitamin D levels and kidney disease component summary and mental component summary scores in pre-dialysis CKD patients.

AB - Vitamin D deficiency is a growing health problem in both the general population and in patients with chronic kidney disease (CKD). However, the relationship between serum 25-hydroxyvitamin D levels and health-related quality of life in CKD is not well established. This study examined the association between vitamin D deficiency and quality of life in pre-dialysis CKD patients. Serum 25-hydroxyvitamin D levels and the Korean version of the Kidney Disease Quality of Life short form were obtained for 1844 pre-dialysis CKD patients in the prospective KoreaN cohort Study for Outcomes in patients With Chronic Kidney Disease (KNOW-CKD). The baseline estimated glomerular filtration rate was 50.26 ± 0.71 mL/min/1.73 m2. We identified 1294 (70.2%) patients with vitamin D deficiency, defined as a 25-hydroxyvitamin D level < 20 ng/ml. The scores of the kidney disease component summary, physical component summary, and mental component summary in the vitamin D deficiency group were significantly lower compared to the scores of those without vitamin D deficiency. The serum 25-hydroxyvitamin D level was independently associated with the kidney disease component summary and mental component summary scores (β = 0.147, p = 0.003 and β = 0.151, p = 0.047). In conclusion, there was a significant association between serum 25-hydroxyvitamin D levels and kidney disease component summary and mental component summary scores in pre-dialysis CKD patients.

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DO - 10.1371/journal.pone.0174282

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