Association between vitamin D deficiency and tuberculosis in a Korean population

J. Y. Hong, S. Y. Kim, K. S. Chung, E. Y. Kim, J. Y. Jung, M. S. Park, Y. S. Kim, S. K. Kim, J. Chang, Young Ae Kang

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35 Citations (Scopus)

Abstract

BACKGROUND: Several in vitro studies have been conducted regarding the immunomodulatory and mycobactericidal roles of vitamin D in tuberculous infection. However, discrepancies exist among epidemiological studies. We compared vitamin D deficiency between patients with tuberculosis (TB) and healthy control subjects and identified risk factors for vitamin D deficiency. METHOD: This was an age- and sex-matched casec ontrol analysis of 94 TB cohort and 282 Korean national survey participants. RESULTS: The median baseline 25-hydroxyvitamin D (25[OH]D) level in the TB group (9.86 ng/ml, IQR 7.19-14.15) was lower than in controls (16.03 ng/ml, IQR 12.38-20.30, P < 0.001). The prevalence of severe vitamin D deficiency was higher in patients with TB (51.1%) than in controls (8.2%, P = 0.001). The median 25(OH)D level increased from 11.40 ng/ml (IQR 7.85-15.73) to 13.18 ng/ml (IQR 10.60-19.71) after treatment completion (P = 0.037). On multivariate analysis, presence of TB and history of TB were independently associated with severe vitamin D deficiency. CONCLUSION: Patients with TB had a higher prevalence of vitamin D deficiency than control subjects in a Korean population. The median 25(OH)D level increased after TB treatment. Further studies are needed to establish a causal relationship.

Original languageEnglish
Pages (from-to)73-78
Number of pages6
JournalInternational Journal of Tuberculosis and Lung Disease
Volume18
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases

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