Abstract
BACKGROUND: Several in vitro studies have been conducted regarding the immunomodulatory and mycobactericidal roles of vitamin D in tuberculous infection. However, discrepancies exist among epidemiological studies. We compared vitamin D deficiency between patients with tuberculosis (TB) and healthy control subjects and identified risk factors for vitamin D deficiency. METHOD: This was an age- and sex-matched casec ontrol analysis of 94 TB cohort and 282 Korean national survey participants. RESULTS: The median baseline 25-hydroxyvitamin D (25[OH]D) level in the TB group (9.86 ng/ml, IQR 7.19-14.15) was lower than in controls (16.03 ng/ml, IQR 12.38-20.30, P < 0.001). The prevalence of severe vitamin D deficiency was higher in patients with TB (51.1%) than in controls (8.2%, P = 0.001). The median 25(OH)D level increased from 11.40 ng/ml (IQR 7.85-15.73) to 13.18 ng/ml (IQR 10.60-19.71) after treatment completion (P = 0.037). On multivariate analysis, presence of TB and history of TB were independently associated with severe vitamin D deficiency. CONCLUSION: Patients with TB had a higher prevalence of vitamin D deficiency than control subjects in a Korean population. The median 25(OH)D level increased after TB treatment. Further studies are needed to establish a causal relationship.
| Original language | English |
|---|---|
| Pages (from-to) | 73-78 |
| Number of pages | 6 |
| Journal | International Journal of Tuberculosis and Lung Disease |
| Volume | 18 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2014 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Pulmonary and Respiratory Medicine
- Infectious Diseases
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Association between vitamin D deficiency and tuberculosis in a Korean population. / Hong, J. Y.; Kim, S. Y.; Chung, K. S.; Kim, E. Y.; Jung, J. Y.; Park, M. S.; Kim, Y. S.; Kim, S. K.; Chang, J.; Kang, Young Ae.
In: International Journal of Tuberculosis and Lung Disease, Vol. 18, No. 1, 01.01.2014, p. 73-78.Research output: Contribution to journal › Article
TY - JOUR
T1 - Association between vitamin D deficiency and tuberculosis in a Korean population
AU - Hong, J. Y.
AU - Kim, S. Y.
AU - Chung, K. S.
AU - Kim, E. Y.
AU - Jung, J. Y.
AU - Park, M. S.
AU - Kim, Y. S.
AU - Kim, S. K.
AU - Chang, J.
AU - Kang, Young Ae
PY - 2014/1/1
Y1 - 2014/1/1
N2 - BACKGROUND: Several in vitro studies have been conducted regarding the immunomodulatory and mycobactericidal roles of vitamin D in tuberculous infection. However, discrepancies exist among epidemiological studies. We compared vitamin D deficiency between patients with tuberculosis (TB) and healthy control subjects and identified risk factors for vitamin D deficiency. METHOD: This was an age- and sex-matched casec ontrol analysis of 94 TB cohort and 282 Korean national survey participants. RESULTS: The median baseline 25-hydroxyvitamin D (25[OH]D) level in the TB group (9.86 ng/ml, IQR 7.19-14.15) was lower than in controls (16.03 ng/ml, IQR 12.38-20.30, P < 0.001). The prevalence of severe vitamin D deficiency was higher in patients with TB (51.1%) than in controls (8.2%, P = 0.001). The median 25(OH)D level increased from 11.40 ng/ml (IQR 7.85-15.73) to 13.18 ng/ml (IQR 10.60-19.71) after treatment completion (P = 0.037). On multivariate analysis, presence of TB and history of TB were independently associated with severe vitamin D deficiency. CONCLUSION: Patients with TB had a higher prevalence of vitamin D deficiency than control subjects in a Korean population. The median 25(OH)D level increased after TB treatment. Further studies are needed to establish a causal relationship.
AB - BACKGROUND: Several in vitro studies have been conducted regarding the immunomodulatory and mycobactericidal roles of vitamin D in tuberculous infection. However, discrepancies exist among epidemiological studies. We compared vitamin D deficiency between patients with tuberculosis (TB) and healthy control subjects and identified risk factors for vitamin D deficiency. METHOD: This was an age- and sex-matched casec ontrol analysis of 94 TB cohort and 282 Korean national survey participants. RESULTS: The median baseline 25-hydroxyvitamin D (25[OH]D) level in the TB group (9.86 ng/ml, IQR 7.19-14.15) was lower than in controls (16.03 ng/ml, IQR 12.38-20.30, P < 0.001). The prevalence of severe vitamin D deficiency was higher in patients with TB (51.1%) than in controls (8.2%, P = 0.001). The median 25(OH)D level increased from 11.40 ng/ml (IQR 7.85-15.73) to 13.18 ng/ml (IQR 10.60-19.71) after treatment completion (P = 0.037). On multivariate analysis, presence of TB and history of TB were independently associated with severe vitamin D deficiency. CONCLUSION: Patients with TB had a higher prevalence of vitamin D deficiency than control subjects in a Korean population. The median 25(OH)D level increased after TB treatment. Further studies are needed to establish a causal relationship.
UR - http://www.scopus.com/inward/record.url?scp=84892587268&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84892587268&partnerID=8YFLogxK
U2 - 10.5588/ijtld.13.0536
DO - 10.5588/ijtld.13.0536
M3 - Article
C2 - 24365556
AN - SCOPUS:84892587268
VL - 18
SP - 73
EP - 78
JO - International Journal of Tuberculosis and Lung Disease
JF - International Journal of Tuberculosis and Lung Disease
SN - 1027-3719
IS - 1
ER -