Association between vitamin D status and asymmetric dimethylarginine (ADMA) concentration in the Korean elderly population

Hye Rin Choi, Seung Won Lee, Hyungseon Yeom, Da Hye Jeon, Hyeon Chang Kim, Yoosik Youm

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objectives Vitamin D deficiency has been reported to be associated with the risk of cardiovascular disease. We investigated the relationship between vitamin D status and asymmetric dimethylarginine (ADMA) concentration, a marker of endothelial dysfunction, in the Korean elderly population. Study design A cross-sectional study was conducted on 269 men and 382 women (mean age, 71.6 years) enrolled in the Korean Social Life, Health, and Aging Project (KSHAP), a population-based longitudinal study of health determinants in elderly Koreans. We stratified patients by vitamin D status into three groups according to serum 25-hydroxyvitamin D [25(OH)D] level: sufficient (≥30 ng/mL, n = 25), insufficient (10- < 30 ng/mL, n = 516), and deficient ( < 10 ng/mL, n = 110). To measure endothelial dysfunction, ADMA concentration was assayed by high-performance liquid chromatography. The association between 25(OH)D status and ADMA concentration was analyzed by multiple linear regression models. Results The mean ADMA concentration was significantly higher in the insufficient 25(OH)D group (0.665 μmol/L, p = 0.001) and the deficient 25(OH)D group (0.734 μmol/L, p < 0.001) compared with the sufficient 25(OH)D group (0.589 μmol/L). Even after adjusting for sex, age, body mass index, blood pressure, diabetes mellitus, total and HDL cholesterol, estimated glomerular filtration rate (eGFR), smoking status, and drinking status, ADMA concentrations were higher in the insufficient group (β = 0.0742 μmol/L, p = 0.001) and the deficient group (β = 0.1417 μmol/L, p < 0.001) compared than in the sufficient group. In a sex-stratified analysis, 25(OH)D deficiency was associated with higher ADMA levels in both women (p < 0.001) and men (p = 0.007), while 25(OH)D deficiency was associated with higher ADMA levels in women (p < 0.001) but not in men (p = 0.631). Conclusion Our findings suggest that low serum 25(OH)D level may be associated with endothelial dysfunction in elderly Korean people.

Original languageEnglish
Pages (from-to)13-17
Number of pages5
JournalMaturitas
Volume102
DOIs
Publication statusPublished - 2017 Aug 1

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Vitamin D
Population
Linear Models
Health
Vitamin D Deficiency
Blood pressure
High performance liquid chromatography
Medical problems
N,N-dimethylarginine
Serum
Glomerular Filtration Rate
Linear regression
HDL Cholesterol
Drinking
Longitudinal Studies
Diabetes Mellitus
Body Mass Index
Cardiovascular Diseases
Cross-Sectional Studies
Aging of materials

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Obstetrics and Gynaecology

Cite this

@article{53048e3cfa224eaf811081c97342b9c2,
title = "Association between vitamin D status and asymmetric dimethylarginine (ADMA) concentration in the Korean elderly population",
abstract = "Objectives Vitamin D deficiency has been reported to be associated with the risk of cardiovascular disease. We investigated the relationship between vitamin D status and asymmetric dimethylarginine (ADMA) concentration, a marker of endothelial dysfunction, in the Korean elderly population. Study design A cross-sectional study was conducted on 269 men and 382 women (mean age, 71.6 years) enrolled in the Korean Social Life, Health, and Aging Project (KSHAP), a population-based longitudinal study of health determinants in elderly Koreans. We stratified patients by vitamin D status into three groups according to serum 25-hydroxyvitamin D [25(OH)D] level: sufficient (≥30 ng/mL, n = 25), insufficient (10- < 30 ng/mL, n = 516), and deficient ( < 10 ng/mL, n = 110). To measure endothelial dysfunction, ADMA concentration was assayed by high-performance liquid chromatography. The association between 25(OH)D status and ADMA concentration was analyzed by multiple linear regression models. Results The mean ADMA concentration was significantly higher in the insufficient 25(OH)D group (0.665 μmol/L, p = 0.001) and the deficient 25(OH)D group (0.734 μmol/L, p < 0.001) compared with the sufficient 25(OH)D group (0.589 μmol/L). Even after adjusting for sex, age, body mass index, blood pressure, diabetes mellitus, total and HDL cholesterol, estimated glomerular filtration rate (eGFR), smoking status, and drinking status, ADMA concentrations were higher in the insufficient group (β = 0.0742 μmol/L, p = 0.001) and the deficient group (β = 0.1417 μmol/L, p < 0.001) compared than in the sufficient group. In a sex-stratified analysis, 25(OH)D deficiency was associated with higher ADMA levels in both women (p < 0.001) and men (p = 0.007), while 25(OH)D deficiency was associated with higher ADMA levels in women (p < 0.001) but not in men (p = 0.631). Conclusion Our findings suggest that low serum 25(OH)D level may be associated with endothelial dysfunction in elderly Korean people.",
author = "Choi, {Hye Rin} and Lee, {Seung Won} and Hyungseon Yeom and Jeon, {Da Hye} and Kim, {Hyeon Chang} and Yoosik Youm",
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month = "8",
day = "1",
doi = "10.1016/j.maturitas.2017.05.002",
language = "English",
volume = "102",
pages = "13--17",
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Association between vitamin D status and asymmetric dimethylarginine (ADMA) concentration in the Korean elderly population. / Choi, Hye Rin; Lee, Seung Won; Yeom, Hyungseon; Jeon, Da Hye; Kim, Hyeon Chang; Youm, Yoosik.

In: Maturitas, Vol. 102, 01.08.2017, p. 13-17.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association between vitamin D status and asymmetric dimethylarginine (ADMA) concentration in the Korean elderly population

AU - Choi, Hye Rin

AU - Lee, Seung Won

AU - Yeom, Hyungseon

AU - Jeon, Da Hye

AU - Kim, Hyeon Chang

AU - Youm, Yoosik

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Objectives Vitamin D deficiency has been reported to be associated with the risk of cardiovascular disease. We investigated the relationship between vitamin D status and asymmetric dimethylarginine (ADMA) concentration, a marker of endothelial dysfunction, in the Korean elderly population. Study design A cross-sectional study was conducted on 269 men and 382 women (mean age, 71.6 years) enrolled in the Korean Social Life, Health, and Aging Project (KSHAP), a population-based longitudinal study of health determinants in elderly Koreans. We stratified patients by vitamin D status into three groups according to serum 25-hydroxyvitamin D [25(OH)D] level: sufficient (≥30 ng/mL, n = 25), insufficient (10- < 30 ng/mL, n = 516), and deficient ( < 10 ng/mL, n = 110). To measure endothelial dysfunction, ADMA concentration was assayed by high-performance liquid chromatography. The association between 25(OH)D status and ADMA concentration was analyzed by multiple linear regression models. Results The mean ADMA concentration was significantly higher in the insufficient 25(OH)D group (0.665 μmol/L, p = 0.001) and the deficient 25(OH)D group (0.734 μmol/L, p < 0.001) compared with the sufficient 25(OH)D group (0.589 μmol/L). Even after adjusting for sex, age, body mass index, blood pressure, diabetes mellitus, total and HDL cholesterol, estimated glomerular filtration rate (eGFR), smoking status, and drinking status, ADMA concentrations were higher in the insufficient group (β = 0.0742 μmol/L, p = 0.001) and the deficient group (β = 0.1417 μmol/L, p < 0.001) compared than in the sufficient group. In a sex-stratified analysis, 25(OH)D deficiency was associated with higher ADMA levels in both women (p < 0.001) and men (p = 0.007), while 25(OH)D deficiency was associated with higher ADMA levels in women (p < 0.001) but not in men (p = 0.631). Conclusion Our findings suggest that low serum 25(OH)D level may be associated with endothelial dysfunction in elderly Korean people.

AB - Objectives Vitamin D deficiency has been reported to be associated with the risk of cardiovascular disease. We investigated the relationship between vitamin D status and asymmetric dimethylarginine (ADMA) concentration, a marker of endothelial dysfunction, in the Korean elderly population. Study design A cross-sectional study was conducted on 269 men and 382 women (mean age, 71.6 years) enrolled in the Korean Social Life, Health, and Aging Project (KSHAP), a population-based longitudinal study of health determinants in elderly Koreans. We stratified patients by vitamin D status into three groups according to serum 25-hydroxyvitamin D [25(OH)D] level: sufficient (≥30 ng/mL, n = 25), insufficient (10- < 30 ng/mL, n = 516), and deficient ( < 10 ng/mL, n = 110). To measure endothelial dysfunction, ADMA concentration was assayed by high-performance liquid chromatography. The association between 25(OH)D status and ADMA concentration was analyzed by multiple linear regression models. Results The mean ADMA concentration was significantly higher in the insufficient 25(OH)D group (0.665 μmol/L, p = 0.001) and the deficient 25(OH)D group (0.734 μmol/L, p < 0.001) compared with the sufficient 25(OH)D group (0.589 μmol/L). Even after adjusting for sex, age, body mass index, blood pressure, diabetes mellitus, total and HDL cholesterol, estimated glomerular filtration rate (eGFR), smoking status, and drinking status, ADMA concentrations were higher in the insufficient group (β = 0.0742 μmol/L, p = 0.001) and the deficient group (β = 0.1417 μmol/L, p < 0.001) compared than in the sufficient group. In a sex-stratified analysis, 25(OH)D deficiency was associated with higher ADMA levels in both women (p < 0.001) and men (p = 0.007), while 25(OH)D deficiency was associated with higher ADMA levels in women (p < 0.001) but not in men (p = 0.631). Conclusion Our findings suggest that low serum 25(OH)D level may be associated with endothelial dysfunction in elderly Korean people.

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DO - 10.1016/j.maturitas.2017.05.002

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