Association of α-adducin Gly460Trp polymorphism with coronary artery disease in a Korean population

Seung Hun Cha, Hung Tae Kim, Yangsoo Jang, Sungha Park, Jae Jung Kim, Min Young Song, Jin Hyoung Park, Ha Jung Ryu, Hyun Young Park, Sung Joo Kim Yoon, Kuchan Kimm, Jong Keuk Lee, Bermseok Oh

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Abstract

OBJECTIVE: Coronary artery disease is caused by multiple genetic and environmental factors. The disease is also closely associated with cardiovascular conditions such as hypertension. In order to investigate any possible role of hypertension candidate genes in the disease development and progression, we examined the association of the polymorphisms of 31 hypertension candidate genes with coronary artery disease. METHODS: Genetic polymorphisms of 31 hypertension candidate genes were initially screened by resequencing DNA samples from 24 unrelated individuals in a Korean population. Association analysis was performed using 1284 unrelated Korean men, including 749 coronary artery disease subjects and 535 normal healthy controls. RESULTS: We identified a total of 409 single nucleotide polymorphisms including 40 nonsynonymous single nucleotide polymorphisms, 32 insertions/deletions and four microsatellites. Among 40 nonsynonymous single nucleotide polymorphisms, 29 were examined for an association with coronary artery disease. A significant association with coronary artery disease was observed in a polymorphism of the ADD1 gene (Gly460Trp; +29017G/T) (odds ratio 0.71-0.81; P = 0.01-0.04). The same polymorphism was also associated with the number of arteries with significant coronary artery stenosis in the coronary artery disease patients (P = 0.01) as well as the increase in systolic blood pressure (P = 0.02). CONCLUSIONS: The ADD1 Gly460Trp polymorphism is significantly associated with an increased risk of coronary artery disease as well as blood pressure, indicating that ADD1 plays a role in the pathogenesis of coronary artery disease as well as hypertension.

Original languageEnglish
Pages (from-to)2413-2420
Number of pages8
JournalJournal of hypertension
Volume25
Issue number12
DOIs
Publication statusPublished - 2007 Dec 1

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All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Cha, S. H., Kim, H. T., Jang, Y., Park, S., Kim, J. J., Song, M. Y., Park, J. H., Ryu, H. J., Park, H. Y., Yoon, S. J. K., Kimm, K., Lee, J. K., & Oh, B. (2007). Association of α-adducin Gly460Trp polymorphism with coronary artery disease in a Korean population. Journal of hypertension, 25(12), 2413-2420. https://doi.org/10.1097/HJH.0b013e3282efedb5