Association of a genetic variant of BTN2A1 with metabolic syndrome in East Asian populations

Mitsutoshi Oguri, Kimihiko Kato, Tetsuro Yoshida, Tetsuo Fujimaki, Hideki Horibe, Kiyoshi Yokoi, Sachiro Watanabe, Kei Satoh, Yukitoshi Aoyagi, Masashi Tanaka, Hiroto Yoshida, Shoji Shinkai, Yoshinori Nozawa, Dong Jik Shin, Jon Ho Lee, Yangsoo Jang, Yoshiji Yamada

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background: The authors previously showed that the C→T polymorphism (rs6929846) of butyrophilin, subfamily 2, member A1 gene (BTN2A1) was significantly associated with myocardial infarction in Japanese individuals. Given that metabolic syndrome (MetS) is an important risk factor for myocardial infarction, the association of the rs6929846 of BTN2A1 with myocardial infarction might be attributable, at least in part, to its effect on susceptibility to MetS. Aim: The aim of the present study was to examine the relation of the rs6929846 of BTN2A1 to MetS in East Asian populations. Methods: The study population comprised 5210 Japanese or Korean individuals (3982 individuals with MetS, 1228 controls) from three independent subject panels. Japanese subject panels A and B comprised 1322 individuals with MetS and 654 controls, and 1909 individuals with MetS and 170 controls, respectively, whereas the Korean population samples comprised 751 individuals with MetS and 404 controls. Results: Comparison of genotype distributions using the χ 2 test revealed that the genotype distributions and allele frequencies of rs6929846 were significantly (p<0.05) associated with MetS in Japanese subject panels A (T allele frequency: MetS, 0.091; controls, 0.054; p=6.1310 -5) and B (T allele frequency: MetS, 0.091; controls, 0.039; p=0013) but not in the Korean population samples (T allele frequency: MetS, 0.102; controls, 0.125; p=0.0997). Multivariable logistic regression analysis with adjustment for covariates revealed that the rs6929846 of BTN2A1 was significantly (p<0.017) associated with MetS in Japanese subject panel A (p=0.0055, OR 1.97) and in all individuals (p=0.0038, OR 1.38), with the T allele representing a risk factor for this condition. Conclusion: BTN2A1 may be a susceptible gene for MetS in Japanese individuals.

Original languageEnglish
Pages (from-to)787-792
Number of pages6
JournalJournal of Medical Genetics
Volume48
Issue number11
DOIs
Publication statusPublished - 2011 Nov 1

Fingerprint

Population
Gene Frequency
Myocardial Infarction
Genotype
Genes
Logistic Models
Alleles
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

Cite this

Oguri, M., Kato, K., Yoshida, T., Fujimaki, T., Horibe, H., Yokoi, K., ... Yamada, Y. (2011). Association of a genetic variant of BTN2A1 with metabolic syndrome in East Asian populations. Journal of Medical Genetics, 48(11), 787-792. https://doi.org/10.1136/jmg.2010.088138
Oguri, Mitsutoshi ; Kato, Kimihiko ; Yoshida, Tetsuro ; Fujimaki, Tetsuo ; Horibe, Hideki ; Yokoi, Kiyoshi ; Watanabe, Sachiro ; Satoh, Kei ; Aoyagi, Yukitoshi ; Tanaka, Masashi ; Yoshida, Hiroto ; Shinkai, Shoji ; Nozawa, Yoshinori ; Shin, Dong Jik ; Lee, Jon Ho ; Jang, Yangsoo ; Yamada, Yoshiji. / Association of a genetic variant of BTN2A1 with metabolic syndrome in East Asian populations. In: Journal of Medical Genetics. 2011 ; Vol. 48, No. 11. pp. 787-792.
@article{7988d09d89a042e88086a1143823f887,
title = "Association of a genetic variant of BTN2A1 with metabolic syndrome in East Asian populations",
abstract = "Background: The authors previously showed that the C→T polymorphism (rs6929846) of butyrophilin, subfamily 2, member A1 gene (BTN2A1) was significantly associated with myocardial infarction in Japanese individuals. Given that metabolic syndrome (MetS) is an important risk factor for myocardial infarction, the association of the rs6929846 of BTN2A1 with myocardial infarction might be attributable, at least in part, to its effect on susceptibility to MetS. Aim: The aim of the present study was to examine the relation of the rs6929846 of BTN2A1 to MetS in East Asian populations. Methods: The study population comprised 5210 Japanese or Korean individuals (3982 individuals with MetS, 1228 controls) from three independent subject panels. Japanese subject panels A and B comprised 1322 individuals with MetS and 654 controls, and 1909 individuals with MetS and 170 controls, respectively, whereas the Korean population samples comprised 751 individuals with MetS and 404 controls. Results: Comparison of genotype distributions using the χ 2 test revealed that the genotype distributions and allele frequencies of rs6929846 were significantly (p<0.05) associated with MetS in Japanese subject panels A (T allele frequency: MetS, 0.091; controls, 0.054; p=6.1310 -5) and B (T allele frequency: MetS, 0.091; controls, 0.039; p=0013) but not in the Korean population samples (T allele frequency: MetS, 0.102; controls, 0.125; p=0.0997). Multivariable logistic regression analysis with adjustment for covariates revealed that the rs6929846 of BTN2A1 was significantly (p<0.017) associated with MetS in Japanese subject panel A (p=0.0055, OR 1.97) and in all individuals (p=0.0038, OR 1.38), with the T allele representing a risk factor for this condition. Conclusion: BTN2A1 may be a susceptible gene for MetS in Japanese individuals.",
author = "Mitsutoshi Oguri and Kimihiko Kato and Tetsuro Yoshida and Tetsuo Fujimaki and Hideki Horibe and Kiyoshi Yokoi and Sachiro Watanabe and Kei Satoh and Yukitoshi Aoyagi and Masashi Tanaka and Hiroto Yoshida and Shoji Shinkai and Yoshinori Nozawa and Shin, {Dong Jik} and Lee, {Jon Ho} and Yangsoo Jang and Yoshiji Yamada",
year = "2011",
month = "11",
day = "1",
doi = "10.1136/jmg.2010.088138",
language = "English",
volume = "48",
pages = "787--792",
journal = "Journal of Medical Genetics",
issn = "0022-2593",
publisher = "BMJ Publishing Group",
number = "11",

}

Oguri, M, Kato, K, Yoshida, T, Fujimaki, T, Horibe, H, Yokoi, K, Watanabe, S, Satoh, K, Aoyagi, Y, Tanaka, M, Yoshida, H, Shinkai, S, Nozawa, Y, Shin, DJ, Lee, JH, Jang, Y & Yamada, Y 2011, 'Association of a genetic variant of BTN2A1 with metabolic syndrome in East Asian populations', Journal of Medical Genetics, vol. 48, no. 11, pp. 787-792. https://doi.org/10.1136/jmg.2010.088138

Association of a genetic variant of BTN2A1 with metabolic syndrome in East Asian populations. / Oguri, Mitsutoshi; Kato, Kimihiko; Yoshida, Tetsuro; Fujimaki, Tetsuo; Horibe, Hideki; Yokoi, Kiyoshi; Watanabe, Sachiro; Satoh, Kei; Aoyagi, Yukitoshi; Tanaka, Masashi; Yoshida, Hiroto; Shinkai, Shoji; Nozawa, Yoshinori; Shin, Dong Jik; Lee, Jon Ho; Jang, Yangsoo; Yamada, Yoshiji.

In: Journal of Medical Genetics, Vol. 48, No. 11, 01.11.2011, p. 787-792.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of a genetic variant of BTN2A1 with metabolic syndrome in East Asian populations

AU - Oguri, Mitsutoshi

AU - Kato, Kimihiko

AU - Yoshida, Tetsuro

AU - Fujimaki, Tetsuo

AU - Horibe, Hideki

AU - Yokoi, Kiyoshi

AU - Watanabe, Sachiro

AU - Satoh, Kei

AU - Aoyagi, Yukitoshi

AU - Tanaka, Masashi

AU - Yoshida, Hiroto

AU - Shinkai, Shoji

AU - Nozawa, Yoshinori

AU - Shin, Dong Jik

AU - Lee, Jon Ho

AU - Jang, Yangsoo

AU - Yamada, Yoshiji

PY - 2011/11/1

Y1 - 2011/11/1

N2 - Background: The authors previously showed that the C→T polymorphism (rs6929846) of butyrophilin, subfamily 2, member A1 gene (BTN2A1) was significantly associated with myocardial infarction in Japanese individuals. Given that metabolic syndrome (MetS) is an important risk factor for myocardial infarction, the association of the rs6929846 of BTN2A1 with myocardial infarction might be attributable, at least in part, to its effect on susceptibility to MetS. Aim: The aim of the present study was to examine the relation of the rs6929846 of BTN2A1 to MetS in East Asian populations. Methods: The study population comprised 5210 Japanese or Korean individuals (3982 individuals with MetS, 1228 controls) from three independent subject panels. Japanese subject panels A and B comprised 1322 individuals with MetS and 654 controls, and 1909 individuals with MetS and 170 controls, respectively, whereas the Korean population samples comprised 751 individuals with MetS and 404 controls. Results: Comparison of genotype distributions using the χ 2 test revealed that the genotype distributions and allele frequencies of rs6929846 were significantly (p<0.05) associated with MetS in Japanese subject panels A (T allele frequency: MetS, 0.091; controls, 0.054; p=6.1310 -5) and B (T allele frequency: MetS, 0.091; controls, 0.039; p=0013) but not in the Korean population samples (T allele frequency: MetS, 0.102; controls, 0.125; p=0.0997). Multivariable logistic regression analysis with adjustment for covariates revealed that the rs6929846 of BTN2A1 was significantly (p<0.017) associated with MetS in Japanese subject panel A (p=0.0055, OR 1.97) and in all individuals (p=0.0038, OR 1.38), with the T allele representing a risk factor for this condition. Conclusion: BTN2A1 may be a susceptible gene for MetS in Japanese individuals.

AB - Background: The authors previously showed that the C→T polymorphism (rs6929846) of butyrophilin, subfamily 2, member A1 gene (BTN2A1) was significantly associated with myocardial infarction in Japanese individuals. Given that metabolic syndrome (MetS) is an important risk factor for myocardial infarction, the association of the rs6929846 of BTN2A1 with myocardial infarction might be attributable, at least in part, to its effect on susceptibility to MetS. Aim: The aim of the present study was to examine the relation of the rs6929846 of BTN2A1 to MetS in East Asian populations. Methods: The study population comprised 5210 Japanese or Korean individuals (3982 individuals with MetS, 1228 controls) from three independent subject panels. Japanese subject panels A and B comprised 1322 individuals with MetS and 654 controls, and 1909 individuals with MetS and 170 controls, respectively, whereas the Korean population samples comprised 751 individuals with MetS and 404 controls. Results: Comparison of genotype distributions using the χ 2 test revealed that the genotype distributions and allele frequencies of rs6929846 were significantly (p<0.05) associated with MetS in Japanese subject panels A (T allele frequency: MetS, 0.091; controls, 0.054; p=6.1310 -5) and B (T allele frequency: MetS, 0.091; controls, 0.039; p=0013) but not in the Korean population samples (T allele frequency: MetS, 0.102; controls, 0.125; p=0.0997). Multivariable logistic regression analysis with adjustment for covariates revealed that the rs6929846 of BTN2A1 was significantly (p<0.017) associated with MetS in Japanese subject panel A (p=0.0055, OR 1.97) and in all individuals (p=0.0038, OR 1.38), with the T allele representing a risk factor for this condition. Conclusion: BTN2A1 may be a susceptible gene for MetS in Japanese individuals.

UR - http://www.scopus.com/inward/record.url?scp=81155133990&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81155133990&partnerID=8YFLogxK

U2 - 10.1136/jmg.2010.088138

DO - 10.1136/jmg.2010.088138

M3 - Article

C2 - 21784758

AN - SCOPUS:81155133990

VL - 48

SP - 787

EP - 792

JO - Journal of Medical Genetics

JF - Journal of Medical Genetics

SN - 0022-2593

IS - 11

ER -