Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations

Yoshiji Yamada, Tamotsu Nishida, Sahoko Ichihara, Motoji Sawabe, Noriyuki Fuku, Yutaka Nishigaki, Yukitoshi Aoyagi, Masashi Tanaka, Yoshinori Fujiwara, Hiroto Yoshida, Shoji Shinkai, Kei Satoh, Kimihiko Kato, Tetsuo Fujimaki, Kiyoshi Yokoi, Mitsutoshi Oguri, Tetsuro Yoshida, Sachiro Watanabe, Yoshinori Nozawa, Aki HasegawaToshio Kojima, Bok Ghee Han, Younjin Ahn, Meehee Lee, Dong Jik Shin, Jong Ho Lee, Yangsoo Jang

Research output: Contribution to journalArticle

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Abstract

Objective: We have performed a genome-wide association study (GWAS) to identify genetic variants that confer susceptibility to myocardial infarction (MI) in Japanese and Korean populations. Methods: A total of 17,447 Japanese or Korean individuals from four independent subject panels was examined. Japanese subject panels A, B, and C comprised 134 individuals with MI and 137 controls, 1431 individuals with MI and 3161 controls, and 643 individuals with MI and 1347 controls, respectively, whereas the Korean population comprised 1880 individuals with MI and 8714 controls. A GWAS for MI was performed in Japanese subject panel A with the use of the Affymetrix GeneChip Human Mapping 500K Array Set. Results: Seventy single nucleotide polymorphisms (SNPs) significantly (P<1.0×10-7) associated with MI by the GWAS were examined further in Japanese subject panel B, revealing two SNPs (rs6929846 of BTN2A1, rs2569512 of ILF3) to be significantly (P<0.0007) associated with MI. The rs6929846 SNP of BTN2A1, but not rs2569512 of ILF3, was also significantly associated with MI in Japanese subject panel C. However, the association of neither rs6929846 nor rs2569512 with MI was replicated in the Korean population. Conclusion: BTN2A1 may be a susceptibility gene for MI in Japanese individuals.

Original languageEnglish
Pages (from-to)145-152
Number of pages8
JournalAtherosclerosis
Volume215
Issue number1
DOIs
Publication statusPublished - 2011 Mar 1

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Myocardial Infarction
Population
Genome-Wide Association Study
Single Nucleotide Polymorphism
Genes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Yamada, Yoshiji ; Nishida, Tamotsu ; Ichihara, Sahoko ; Sawabe, Motoji ; Fuku, Noriyuki ; Nishigaki, Yutaka ; Aoyagi, Yukitoshi ; Tanaka, Masashi ; Fujiwara, Yoshinori ; Yoshida, Hiroto ; Shinkai, Shoji ; Satoh, Kei ; Kato, Kimihiko ; Fujimaki, Tetsuo ; Yokoi, Kiyoshi ; Oguri, Mitsutoshi ; Yoshida, Tetsuro ; Watanabe, Sachiro ; Nozawa, Yoshinori ; Hasegawa, Aki ; Kojima, Toshio ; Han, Bok Ghee ; Ahn, Younjin ; Lee, Meehee ; Shin, Dong Jik ; Lee, Jong Ho ; Jang, Yangsoo. / Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations. In: Atherosclerosis. 2011 ; Vol. 215, No. 1. pp. 145-152.
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abstract = "Objective: We have performed a genome-wide association study (GWAS) to identify genetic variants that confer susceptibility to myocardial infarction (MI) in Japanese and Korean populations. Methods: A total of 17,447 Japanese or Korean individuals from four independent subject panels was examined. Japanese subject panels A, B, and C comprised 134 individuals with MI and 137 controls, 1431 individuals with MI and 3161 controls, and 643 individuals with MI and 1347 controls, respectively, whereas the Korean population comprised 1880 individuals with MI and 8714 controls. A GWAS for MI was performed in Japanese subject panel A with the use of the Affymetrix GeneChip Human Mapping 500K Array Set. Results: Seventy single nucleotide polymorphisms (SNPs) significantly (P<1.0×10-7) associated with MI by the GWAS were examined further in Japanese subject panel B, revealing two SNPs (rs6929846 of BTN2A1, rs2569512 of ILF3) to be significantly (P<0.0007) associated with MI. The rs6929846 SNP of BTN2A1, but not rs2569512 of ILF3, was also significantly associated with MI in Japanese subject panel C. However, the association of neither rs6929846 nor rs2569512 with MI was replicated in the Korean population. Conclusion: BTN2A1 may be a susceptibility gene for MI in Japanese individuals.",
author = "Yoshiji Yamada and Tamotsu Nishida and Sahoko Ichihara and Motoji Sawabe and Noriyuki Fuku and Yutaka Nishigaki and Yukitoshi Aoyagi and Masashi Tanaka and Yoshinori Fujiwara and Hiroto Yoshida and Shoji Shinkai and Kei Satoh and Kimihiko Kato and Tetsuo Fujimaki and Kiyoshi Yokoi and Mitsutoshi Oguri and Tetsuro Yoshida and Sachiro Watanabe and Yoshinori Nozawa and Aki Hasegawa and Toshio Kojima and Han, {Bok Ghee} and Younjin Ahn and Meehee Lee and Shin, {Dong Jik} and Lee, {Jong Ho} and Yangsoo Jang",
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Yamada, Y, Nishida, T, Ichihara, S, Sawabe, M, Fuku, N, Nishigaki, Y, Aoyagi, Y, Tanaka, M, Fujiwara, Y, Yoshida, H, Shinkai, S, Satoh, K, Kato, K, Fujimaki, T, Yokoi, K, Oguri, M, Yoshida, T, Watanabe, S, Nozawa, Y, Hasegawa, A, Kojima, T, Han, BG, Ahn, Y, Lee, M, Shin, DJ, Lee, JH & Jang, Y 2011, 'Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations', Atherosclerosis, vol. 215, no. 1, pp. 145-152. https://doi.org/10.1016/j.atherosclerosis.2010.12.005

Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations. / Yamada, Yoshiji; Nishida, Tamotsu; Ichihara, Sahoko; Sawabe, Motoji; Fuku, Noriyuki; Nishigaki, Yutaka; Aoyagi, Yukitoshi; Tanaka, Masashi; Fujiwara, Yoshinori; Yoshida, Hiroto; Shinkai, Shoji; Satoh, Kei; Kato, Kimihiko; Fujimaki, Tetsuo; Yokoi, Kiyoshi; Oguri, Mitsutoshi; Yoshida, Tetsuro; Watanabe, Sachiro; Nozawa, Yoshinori; Hasegawa, Aki; Kojima, Toshio; Han, Bok Ghee; Ahn, Younjin; Lee, Meehee; Shin, Dong Jik; Lee, Jong Ho; Jang, Yangsoo.

In: Atherosclerosis, Vol. 215, No. 1, 01.03.2011, p. 145-152.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations

AU - Yamada, Yoshiji

AU - Nishida, Tamotsu

AU - Ichihara, Sahoko

AU - Sawabe, Motoji

AU - Fuku, Noriyuki

AU - Nishigaki, Yutaka

AU - Aoyagi, Yukitoshi

AU - Tanaka, Masashi

AU - Fujiwara, Yoshinori

AU - Yoshida, Hiroto

AU - Shinkai, Shoji

AU - Satoh, Kei

AU - Kato, Kimihiko

AU - Fujimaki, Tetsuo

AU - Yokoi, Kiyoshi

AU - Oguri, Mitsutoshi

AU - Yoshida, Tetsuro

AU - Watanabe, Sachiro

AU - Nozawa, Yoshinori

AU - Hasegawa, Aki

AU - Kojima, Toshio

AU - Han, Bok Ghee

AU - Ahn, Younjin

AU - Lee, Meehee

AU - Shin, Dong Jik

AU - Lee, Jong Ho

AU - Jang, Yangsoo

PY - 2011/3/1

Y1 - 2011/3/1

N2 - Objective: We have performed a genome-wide association study (GWAS) to identify genetic variants that confer susceptibility to myocardial infarction (MI) in Japanese and Korean populations. Methods: A total of 17,447 Japanese or Korean individuals from four independent subject panels was examined. Japanese subject panels A, B, and C comprised 134 individuals with MI and 137 controls, 1431 individuals with MI and 3161 controls, and 643 individuals with MI and 1347 controls, respectively, whereas the Korean population comprised 1880 individuals with MI and 8714 controls. A GWAS for MI was performed in Japanese subject panel A with the use of the Affymetrix GeneChip Human Mapping 500K Array Set. Results: Seventy single nucleotide polymorphisms (SNPs) significantly (P<1.0×10-7) associated with MI by the GWAS were examined further in Japanese subject panel B, revealing two SNPs (rs6929846 of BTN2A1, rs2569512 of ILF3) to be significantly (P<0.0007) associated with MI. The rs6929846 SNP of BTN2A1, but not rs2569512 of ILF3, was also significantly associated with MI in Japanese subject panel C. However, the association of neither rs6929846 nor rs2569512 with MI was replicated in the Korean population. Conclusion: BTN2A1 may be a susceptibility gene for MI in Japanese individuals.

AB - Objective: We have performed a genome-wide association study (GWAS) to identify genetic variants that confer susceptibility to myocardial infarction (MI) in Japanese and Korean populations. Methods: A total of 17,447 Japanese or Korean individuals from four independent subject panels was examined. Japanese subject panels A, B, and C comprised 134 individuals with MI and 137 controls, 1431 individuals with MI and 3161 controls, and 643 individuals with MI and 1347 controls, respectively, whereas the Korean population comprised 1880 individuals with MI and 8714 controls. A GWAS for MI was performed in Japanese subject panel A with the use of the Affymetrix GeneChip Human Mapping 500K Array Set. Results: Seventy single nucleotide polymorphisms (SNPs) significantly (P<1.0×10-7) associated with MI by the GWAS were examined further in Japanese subject panel B, revealing two SNPs (rs6929846 of BTN2A1, rs2569512 of ILF3) to be significantly (P<0.0007) associated with MI. The rs6929846 SNP of BTN2A1, but not rs2569512 of ILF3, was also significantly associated with MI in Japanese subject panel C. However, the association of neither rs6929846 nor rs2569512 with MI was replicated in the Korean population. Conclusion: BTN2A1 may be a susceptibility gene for MI in Japanese individuals.

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U2 - 10.1016/j.atherosclerosis.2010.12.005

DO - 10.1016/j.atherosclerosis.2010.12.005

M3 - Article

C2 - 21211798

AN - SCOPUS:79952099987

VL - 215

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JO - Atherosclerosis

JF - Atherosclerosis

SN - 0021-9150

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