Association of a RUNX2 promoter polymorphism with bone mineral density in postmenopausal Korean women

Hee Jung Lee, Jung Min Koh, Joo Yeon Hwang, Kang-Yell Choi, Seung Hun Lee, Eui Kyun Park, Tae Ho Kim, Bok Ghee Han, Ghi Su Kim, Shin Yoon Kim, Jong Young Lee

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Osteoporosis is characterized by impaired osteoblastogenesis. Bone mineral density (BMD) is a major determinant of bone strength. RUNX2 is an osteoblast-specific transcription factor involved in osteoblast differentiation and ossification. To determine whether RUNX2 is associated with BMD in an ethnically distinct population, we investigated SNPs within the two RUNX2 promoters (P1 and P2) using the Illuminar GoldenGate system in 729 postmenopausal Korean women. Subjects bearing the minor homozygote genotype (CC) at the RUNX2 -1025 T > C SNP (rs7771980) located in P2 showed a significant association with reduced lumbar spine BMD (p = 0.02) and BMDs at proximal femur sites (trochanter, p = 0.05; total femur, p = 0.04) compared with subjects carrying the major homozygote genotype (TT) or the heterozygote genotype (TC), respectively. These results present an interesting genotype association complementary to the previously reported association of BMD with the RUNX2 -1025 T > C P2 SNP in Spanish and Australian cohorts. Therefore, we suggest that the RUNX2 P2 polymorphism (-1025 T > C) may be a useful genetic marker for bone metabolism and may play an important role in BMD in postmenopausal Korean women.

Original languageEnglish
Pages (from-to)439-445
Number of pages7
JournalCalcified Tissue International
Volume84
Issue number6
DOIs
Publication statusPublished - 2009 Jun 1

Fingerprint

Bone Density
Genotype
Femur
Single Nucleotide Polymorphism
Homozygote
Osteoblasts
Bone and Bones
Heterozygote
Genetic Markers
Osteogenesis
Osteoporosis
Spine
Transcription Factors
Population

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Cite this

Lee, Hee Jung ; Koh, Jung Min ; Hwang, Joo Yeon ; Choi, Kang-Yell ; Lee, Seung Hun ; Park, Eui Kyun ; Kim, Tae Ho ; Han, Bok Ghee ; Kim, Ghi Su ; Kim, Shin Yoon ; Lee, Jong Young. / Association of a RUNX2 promoter polymorphism with bone mineral density in postmenopausal Korean women. In: Calcified Tissue International. 2009 ; Vol. 84, No. 6. pp. 439-445.
@article{0efd4041413d4b1185074a189805e42b,
title = "Association of a RUNX2 promoter polymorphism with bone mineral density in postmenopausal Korean women",
abstract = "Osteoporosis is characterized by impaired osteoblastogenesis. Bone mineral density (BMD) is a major determinant of bone strength. RUNX2 is an osteoblast-specific transcription factor involved in osteoblast differentiation and ossification. To determine whether RUNX2 is associated with BMD in an ethnically distinct population, we investigated SNPs within the two RUNX2 promoters (P1 and P2) using the Illuminar GoldenGate system in 729 postmenopausal Korean women. Subjects bearing the minor homozygote genotype (CC) at the RUNX2 -1025 T > C SNP (rs7771980) located in P2 showed a significant association with reduced lumbar spine BMD (p = 0.02) and BMDs at proximal femur sites (trochanter, p = 0.05; total femur, p = 0.04) compared with subjects carrying the major homozygote genotype (TT) or the heterozygote genotype (TC), respectively. These results present an interesting genotype association complementary to the previously reported association of BMD with the RUNX2 -1025 T > C P2 SNP in Spanish and Australian cohorts. Therefore, we suggest that the RUNX2 P2 polymorphism (-1025 T > C) may be a useful genetic marker for bone metabolism and may play an important role in BMD in postmenopausal Korean women.",
author = "Lee, {Hee Jung} and Koh, {Jung Min} and Hwang, {Joo Yeon} and Kang-Yell Choi and Lee, {Seung Hun} and Park, {Eui Kyun} and Kim, {Tae Ho} and Han, {Bok Ghee} and Kim, {Ghi Su} and Kim, {Shin Yoon} and Lee, {Jong Young}",
year = "2009",
month = "6",
day = "1",
doi = "10.1007/s00223-009-9246-6",
language = "English",
volume = "84",
pages = "439--445",
journal = "Calcified Tissue International",
issn = "0171-967X",
publisher = "Springer New York",
number = "6",

}

Lee, HJ, Koh, JM, Hwang, JY, Choi, K-Y, Lee, SH, Park, EK, Kim, TH, Han, BG, Kim, GS, Kim, SY & Lee, JY 2009, 'Association of a RUNX2 promoter polymorphism with bone mineral density in postmenopausal Korean women', Calcified Tissue International, vol. 84, no. 6, pp. 439-445. https://doi.org/10.1007/s00223-009-9246-6

Association of a RUNX2 promoter polymorphism with bone mineral density in postmenopausal Korean women. / Lee, Hee Jung; Koh, Jung Min; Hwang, Joo Yeon; Choi, Kang-Yell; Lee, Seung Hun; Park, Eui Kyun; Kim, Tae Ho; Han, Bok Ghee; Kim, Ghi Su; Kim, Shin Yoon; Lee, Jong Young.

In: Calcified Tissue International, Vol. 84, No. 6, 01.06.2009, p. 439-445.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of a RUNX2 promoter polymorphism with bone mineral density in postmenopausal Korean women

AU - Lee, Hee Jung

AU - Koh, Jung Min

AU - Hwang, Joo Yeon

AU - Choi, Kang-Yell

AU - Lee, Seung Hun

AU - Park, Eui Kyun

AU - Kim, Tae Ho

AU - Han, Bok Ghee

AU - Kim, Ghi Su

AU - Kim, Shin Yoon

AU - Lee, Jong Young

PY - 2009/6/1

Y1 - 2009/6/1

N2 - Osteoporosis is characterized by impaired osteoblastogenesis. Bone mineral density (BMD) is a major determinant of bone strength. RUNX2 is an osteoblast-specific transcription factor involved in osteoblast differentiation and ossification. To determine whether RUNX2 is associated with BMD in an ethnically distinct population, we investigated SNPs within the two RUNX2 promoters (P1 and P2) using the Illuminar GoldenGate system in 729 postmenopausal Korean women. Subjects bearing the minor homozygote genotype (CC) at the RUNX2 -1025 T > C SNP (rs7771980) located in P2 showed a significant association with reduced lumbar spine BMD (p = 0.02) and BMDs at proximal femur sites (trochanter, p = 0.05; total femur, p = 0.04) compared with subjects carrying the major homozygote genotype (TT) or the heterozygote genotype (TC), respectively. These results present an interesting genotype association complementary to the previously reported association of BMD with the RUNX2 -1025 T > C P2 SNP in Spanish and Australian cohorts. Therefore, we suggest that the RUNX2 P2 polymorphism (-1025 T > C) may be a useful genetic marker for bone metabolism and may play an important role in BMD in postmenopausal Korean women.

AB - Osteoporosis is characterized by impaired osteoblastogenesis. Bone mineral density (BMD) is a major determinant of bone strength. RUNX2 is an osteoblast-specific transcription factor involved in osteoblast differentiation and ossification. To determine whether RUNX2 is associated with BMD in an ethnically distinct population, we investigated SNPs within the two RUNX2 promoters (P1 and P2) using the Illuminar GoldenGate system in 729 postmenopausal Korean women. Subjects bearing the minor homozygote genotype (CC) at the RUNX2 -1025 T > C SNP (rs7771980) located in P2 showed a significant association with reduced lumbar spine BMD (p = 0.02) and BMDs at proximal femur sites (trochanter, p = 0.05; total femur, p = 0.04) compared with subjects carrying the major homozygote genotype (TT) or the heterozygote genotype (TC), respectively. These results present an interesting genotype association complementary to the previously reported association of BMD with the RUNX2 -1025 T > C P2 SNP in Spanish and Australian cohorts. Therefore, we suggest that the RUNX2 P2 polymorphism (-1025 T > C) may be a useful genetic marker for bone metabolism and may play an important role in BMD in postmenopausal Korean women.

UR - http://www.scopus.com/inward/record.url?scp=67349133555&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349133555&partnerID=8YFLogxK

U2 - 10.1007/s00223-009-9246-6

DO - 10.1007/s00223-009-9246-6

M3 - Article

C2 - 19424741

AN - SCOPUS:67349133555

VL - 84

SP - 439

EP - 445

JO - Calcified Tissue International

JF - Calcified Tissue International

SN - 0171-967X

IS - 6

ER -