Association of abdominal obesity with atherosclerosis in type 2 diabetes mellitus (T2DM) in Korea

Minho Cho, Suk Park Jong, Jisun Nam, Sik Kim Chul, Hyun Nam Jae, Jin Kim Hai, Woo Ahn Chul, Soo Cha Bong, Kil Lim Sung, Rae Kim Kyung, Chul Lee Hyun, Bum Huh Kap

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Abstract

The aim of this study was to investigate the relationship between obesity, insulin resistance and atherosclerosis in type 2 diabetes mellitus (T2DM) patients. Total 530 patients with T2DM were included. To evaluate the severity of atherosclerosis, we measured the coronary artery calcification (CAC) score, intima-media thickness (IMT) of the common carotid artery, and the ankle-brachial pressure index (ABPI). Subjects were classified according to body mass index (BMI), a marker of general obesity, and waist-to-hip ratio (WHR), a marker of regional obesity. The insulin sensitivity index (ISI) was measured by the short insulin tolerance test. All subjects were classified into four groups, according to BMI: the under-weight group, the normal-weight (NW) group, the over-weight (OW) group, and the obese (OB) group. WHR and systolic blood pressure, triglycerides (TG), HDL-cholesterol (HDL-C), free fatty acids (FFA), fibrinogen, and fasting c-peptide levels were significantly different between BMI groups. TG, HDL-C, FFA, fibrinogen and ISI were significantly different between patients with and without abdominal obesity. In the OW group as well as in the NW group, carotid IMT, ABPI and CAC score were significantly different between patients with and without abdominal obesity. This study indicates that abdominal obesity was associated with atherosclerosis in T2DM patients.

Original languageEnglish
Pages (from-to)781-788
Number of pages8
JournalJournal of Korean medical science
Volume23
Issue number5
DOIs
Publication statusPublished - 2008 Oct

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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    Cho, M., Jong, S. P., Nam, J., Chul, S. K., Jae, H. N., Hai, J. K., Chul, W. A., Bong, S. C., Sung, K. L., Kyung, R. K., Hyun, C. L., & Kap, B. H. (2008). Association of abdominal obesity with atherosclerosis in type 2 diabetes mellitus (T2DM) in Korea. Journal of Korean medical science, 23(5), 781-788. https://doi.org/10.3346/jkms.2008.23.5.781