Association of aortic plaque with intracranial atherosclerosis in patients with stroke

H. S. Nam, S. W. Han, J. Y. Lee, S. H. Ahn, J. W. Ha, S. J. Rim, B. I. Lee, Jihoe Heo

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

OBJECTIVE: To determine whether there is a relationship between aortic plaques and intracranial (IC) atherosclerosis. METHODS: We reviewed 922 patients with stroke who had both transesophageal echocardiography and cerebral angiography. The plaques of these patients were classified as either complex aortic plaques (CAP), which protruded ≥4 mm or were present as mobile lesions in the proximal aorta, or simple aortic plaques (SAP), which were <4 mm or present in the descending aorta. Cerebral artery atherosclerosis was classified as either an IC or extracranial (EC) atherosclerosis. RESULTS: Among the 922 patients, we found aortic plaques in 237 patients (26%). There were 111 (47%) patients of SAP, 74 (31%) patients with CAP, and 52 (22%) patients that had both SAP and CAP. Angiography showed IC or EC atherosclerosis in 511 patients (55%). The presence of aortic plaques was significantly associated with IC or EC atherosclerosis. The significance appeared to be due to the strong association between the presence of SAP and IC atherosclerosis (51% SAP vs 35% no plaques; odds ratio = 1.94, 95% CI: 1.17 to 3.21). In the multiple logistic regression analysis, SAP were independent predictors of IC atherosclerosis CONCLUSIONS: The presence of simple aortic plaques may be a marker of advanced vascular disease. Detection of simple aortic plaques during transesophageal echocardiography may have clinical implications because patients with these plaques frequently had concomitant intracranial atherosclerosis, a risk factor for stroke.

Original languageEnglish
Pages (from-to)1184-1188
Number of pages5
JournalNeurology
Volume67
Issue number7
DOIs
Publication statusPublished - 2006 Jan 1

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Intracranial Arteriosclerosis
Stroke
Atherosclerosis
Transesophageal Echocardiography
Cerebral Angiography
Cerebral Arteries
Thoracic Aorta
Vascular Diseases
Aorta
Angiography
Logistic Models
Odds Ratio
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Nam, H. S. ; Han, S. W. ; Lee, J. Y. ; Ahn, S. H. ; Ha, J. W. ; Rim, S. J. ; Lee, B. I. ; Heo, Jihoe. / Association of aortic plaque with intracranial atherosclerosis in patients with stroke. In: Neurology. 2006 ; Vol. 67, No. 7. pp. 1184-1188.
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abstract = "OBJECTIVE: To determine whether there is a relationship between aortic plaques and intracranial (IC) atherosclerosis. METHODS: We reviewed 922 patients with stroke who had both transesophageal echocardiography and cerebral angiography. The plaques of these patients were classified as either complex aortic plaques (CAP), which protruded ≥4 mm or were present as mobile lesions in the proximal aorta, or simple aortic plaques (SAP), which were <4 mm or present in the descending aorta. Cerebral artery atherosclerosis was classified as either an IC or extracranial (EC) atherosclerosis. RESULTS: Among the 922 patients, we found aortic plaques in 237 patients (26{\%}). There were 111 (47{\%}) patients of SAP, 74 (31{\%}) patients with CAP, and 52 (22{\%}) patients that had both SAP and CAP. Angiography showed IC or EC atherosclerosis in 511 patients (55{\%}). The presence of aortic plaques was significantly associated with IC or EC atherosclerosis. The significance appeared to be due to the strong association between the presence of SAP and IC atherosclerosis (51{\%} SAP vs 35{\%} no plaques; odds ratio = 1.94, 95{\%} CI: 1.17 to 3.21). In the multiple logistic regression analysis, SAP were independent predictors of IC atherosclerosis CONCLUSIONS: The presence of simple aortic plaques may be a marker of advanced vascular disease. Detection of simple aortic plaques during transesophageal echocardiography may have clinical implications because patients with these plaques frequently had concomitant intracranial atherosclerosis, a risk factor for stroke.",
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Nam, HS, Han, SW, Lee, JY, Ahn, SH, Ha, JW, Rim, SJ, Lee, BI & Heo, J 2006, 'Association of aortic plaque with intracranial atherosclerosis in patients with stroke', Neurology, vol. 67, no. 7, pp. 1184-1188. https://doi.org/10.1212/01.wnl.0000238511.72927.3c

Association of aortic plaque with intracranial atherosclerosis in patients with stroke. / Nam, H. S.; Han, S. W.; Lee, J. Y.; Ahn, S. H.; Ha, J. W.; Rim, S. J.; Lee, B. I.; Heo, Jihoe.

In: Neurology, Vol. 67, No. 7, 01.01.2006, p. 1184-1188.

Research output: Contribution to journalArticle

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AU - Nam, H. S.

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N2 - OBJECTIVE: To determine whether there is a relationship between aortic plaques and intracranial (IC) atherosclerosis. METHODS: We reviewed 922 patients with stroke who had both transesophageal echocardiography and cerebral angiography. The plaques of these patients were classified as either complex aortic plaques (CAP), which protruded ≥4 mm or were present as mobile lesions in the proximal aorta, or simple aortic plaques (SAP), which were <4 mm or present in the descending aorta. Cerebral artery atherosclerosis was classified as either an IC or extracranial (EC) atherosclerosis. RESULTS: Among the 922 patients, we found aortic plaques in 237 patients (26%). There were 111 (47%) patients of SAP, 74 (31%) patients with CAP, and 52 (22%) patients that had both SAP and CAP. Angiography showed IC or EC atherosclerosis in 511 patients (55%). The presence of aortic plaques was significantly associated with IC or EC atherosclerosis. The significance appeared to be due to the strong association between the presence of SAP and IC atherosclerosis (51% SAP vs 35% no plaques; odds ratio = 1.94, 95% CI: 1.17 to 3.21). In the multiple logistic regression analysis, SAP were independent predictors of IC atherosclerosis CONCLUSIONS: The presence of simple aortic plaques may be a marker of advanced vascular disease. Detection of simple aortic plaques during transesophageal echocardiography may have clinical implications because patients with these plaques frequently had concomitant intracranial atherosclerosis, a risk factor for stroke.

AB - OBJECTIVE: To determine whether there is a relationship between aortic plaques and intracranial (IC) atherosclerosis. METHODS: We reviewed 922 patients with stroke who had both transesophageal echocardiography and cerebral angiography. The plaques of these patients were classified as either complex aortic plaques (CAP), which protruded ≥4 mm or were present as mobile lesions in the proximal aorta, or simple aortic plaques (SAP), which were <4 mm or present in the descending aorta. Cerebral artery atherosclerosis was classified as either an IC or extracranial (EC) atherosclerosis. RESULTS: Among the 922 patients, we found aortic plaques in 237 patients (26%). There were 111 (47%) patients of SAP, 74 (31%) patients with CAP, and 52 (22%) patients that had both SAP and CAP. Angiography showed IC or EC atherosclerosis in 511 patients (55%). The presence of aortic plaques was significantly associated with IC or EC atherosclerosis. The significance appeared to be due to the strong association between the presence of SAP and IC atherosclerosis (51% SAP vs 35% no plaques; odds ratio = 1.94, 95% CI: 1.17 to 3.21). In the multiple logistic regression analysis, SAP were independent predictors of IC atherosclerosis CONCLUSIONS: The presence of simple aortic plaques may be a marker of advanced vascular disease. Detection of simple aortic plaques during transesophageal echocardiography may have clinical implications because patients with these plaques frequently had concomitant intracranial atherosclerosis, a risk factor for stroke.

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