Association of aortic plaque with intracranial atherosclerosis in patients with stroke

H. S. Nam, S. W. Han, J. Y. Lee, S. H. Ahn, J. W. Ha, S. J. Rim, B. I. Lee, J. H. Heo

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)


OBJECTIVE: To determine whether there is a relationship between aortic plaques and intracranial (IC) atherosclerosis. METHODS: We reviewed 922 patients with stroke who had both transesophageal echocardiography and cerebral angiography. The plaques of these patients were classified as either complex aortic plaques (CAP), which protruded ≥4 mm or were present as mobile lesions in the proximal aorta, or simple aortic plaques (SAP), which were <4 mm or present in the descending aorta. Cerebral artery atherosclerosis was classified as either an IC or extracranial (EC) atherosclerosis. RESULTS: Among the 922 patients, we found aortic plaques in 237 patients (26%). There were 111 (47%) patients of SAP, 74 (31%) patients with CAP, and 52 (22%) patients that had both SAP and CAP. Angiography showed IC or EC atherosclerosis in 511 patients (55%). The presence of aortic plaques was significantly associated with IC or EC atherosclerosis. The significance appeared to be due to the strong association between the presence of SAP and IC atherosclerosis (51% SAP vs 35% no plaques; odds ratio = 1.94, 95% CI: 1.17 to 3.21). In the multiple logistic regression analysis, SAP were independent predictors of IC atherosclerosis CONCLUSIONS: The presence of simple aortic plaques may be a marker of advanced vascular disease. Detection of simple aortic plaques during transesophageal echocardiography may have clinical implications because patients with these plaques frequently had concomitant intracranial atherosclerosis, a risk factor for stroke.

Original languageEnglish
Pages (from-to)1184-1188
Number of pages5
Issue number7
Publication statusPublished - 2006 Oct

Bibliographical note

Funding Information:
This work is based on observations obtained at the Gemini Observatory, which is operated by the Association of Universities for Research in Astronomy, Inc., under a cooperative agreement with the NSF on behalf of the Gemini partnership: the National Science Foundation (US), the Particle Physics and Astronomy Research Council (UK), the National Research Council (Canada), CONICYT (Chile), the Australian Research Council (Australia), CNPq (Brazil), and CONICET (Argentina). We thank M. Mountain and J.-R. Roy for granting Gemini Director’s Discretionary time and P. Gomez for executing the GMOS observations, I. Jorgensen, M. Bergman, and R. C. Smith for advising us on the calibration and reduction of GMOS data, and N. Walborn for useful discussions regarding spectral classification. This program is supported by the Chandra grant SAO GO-5600587.

All Science Journal Classification (ASJC) codes

  • Clinical Neurology


Dive into the research topics of 'Association of aortic plaque with intracranial atherosclerosis in patients with stroke'. Together they form a unique fingerprint.

Cite this