Objective: Whereas the relation between apolipoprotein A5 (APOA5) gene polymorphisms and triglycerides (TG) levels is well established, the associations between apoA5 concentrations, TG and coronary artery disease (CAD) remain controversial. Therefore, we investigated these relations in the setting of a case-control study involving Korean males. Methods: ApoA5, TG, insulin, free fatty acid (FFA) and lipoprotein profiles were determined using a cross-sectional design in 777 healthy controls and 367 CAD patients. Results: Plasma apoA5 concentration was lower in CAD patients than controls (192.7 ± 5.2 vs. 237.2 ± 3.7 ng/ml, P < 0.001). Values in the second and top tertiles of apoA5 were associated with a decreased odds ratio (OR) for CAD when compared with values in the bottom tertile; OR for apoA5 top tertile was 0.33 (95% CI, 0.23-0.47) in the age- and BMI-adjusted model and 0.35 (95% CI, 0.23-0.56) following additional adjustments for smoking, drinking status, blood pressure, TG and HDL-cholesterol. After adjustment for age and BMI, plasma apoA5 concentration was negatively correlated with serum TG (r = -0.188, P < 0.001) and insulin (r = -0.185, P < 0.001) in normotriglyceridemic controls (TG < 150 mg/dL, n = 509) whereas apoA5 was positively correlated with serum TG in hypertriglyceridemic controls (TG ≥ 150 mg/dL, n = 268) (r = 0.246, P < 0.001) and total CAD patients (r = 0.177, P < 0.01). Regardless of TG levels and CAD status, apoA5 concentration was positively correlated with HDL-cholesterol and FFA levels. Conclusions: Our data supports an inverse association between plasma apoA5 concentrations and CAD risk, probably due to the observed negative correlations of apoA5 with TGs and insulin, although these correlations were affected by TG levels.
|Number of pages||6|
|Publication status||Published - 2009 Aug|
Bibliographical noteFunding Information:
This study was supported by (1) Korea Science and Engineering Foundation (KOSEF) grant (M10642120002-06N4212-00210), Ministry of Science and Technology, Seoul, Korea, (2) National Research Laboratory project #R0A-2005-000-10144-0, Ministry of Science and Technology, Seoul, Korea, (3) Korea Health 21 R&D Projects, Ministry of Health & Welfare (A000385), Seoul, Korea, (4) Korea Research Foundation Grant (KRF-2004-042-C00156), Seoul, Korea, (5) Brain Korea 21 Project, College of Human Ecology, Yonsei University, Seoul, Korea, and (6) Grant 58-1950-9-001 from the US Department of Agriculture Research Service, USA and NIH grants HL54776 and DK075030.
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine