Abstract
Objective: Whereas the relation between apolipoprotein A5 (APOA5) gene polymorphisms and triglycerides (TG) levels is well established, the associations between apoA5 concentrations, TG and coronary artery disease (CAD) remain controversial. Therefore, we investigated these relations in the setting of a case-control study involving Korean males. Methods: ApoA5, TG, insulin, free fatty acid (FFA) and lipoprotein profiles were determined using a cross-sectional design in 777 healthy controls and 367 CAD patients. Results: Plasma apoA5 concentration was lower in CAD patients than controls (192.7 ± 5.2 vs. 237.2 ± 3.7 ng/ml, P < 0.001). Values in the second and top tertiles of apoA5 were associated with a decreased odds ratio (OR) for CAD when compared with values in the bottom tertile; OR for apoA5 top tertile was 0.33 (95% CI, 0.23-0.47) in the age- and BMI-adjusted model and 0.35 (95% CI, 0.23-0.56) following additional adjustments for smoking, drinking status, blood pressure, TG and HDL-cholesterol. After adjustment for age and BMI, plasma apoA5 concentration was negatively correlated with serum TG (r = -0.188, P < 0.001) and insulin (r = -0.185, P < 0.001) in normotriglyceridemic controls (TG < 150 mg/dL, n = 509) whereas apoA5 was positively correlated with serum TG in hypertriglyceridemic controls (TG ≥ 150 mg/dL, n = 268) (r = 0.246, P < 0.001) and total CAD patients (r = 0.177, P < 0.01). Regardless of TG levels and CAD status, apoA5 concentration was positively correlated with HDL-cholesterol and FFA levels. Conclusions: Our data supports an inverse association between plasma apoA5 concentrations and CAD risk, probably due to the observed negative correlations of apoA5 with TGs and insulin, although these correlations were affected by TG levels.
| Original language | English |
|---|---|
| Pages (from-to) | 568-573 |
| Number of pages | 6 |
| Journal | Atherosclerosis |
| Volume | 205 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2009 Aug 1 |
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All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
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Association of apolipoprotein A5 concentration with serum insulin and triglyceride levels and coronary artery disease in Korean men. / Hyun, Yae Jung; Jang, Yangsoo; Chae, Jey Sook; Kim, Ji Young; Paik, Jean Kyung; Kim, So Yeon; Yang, Ju Young; Ordovas, Jose M.; Ko, Young Guk; Lee, Jong Ho.
In: Atherosclerosis, Vol. 205, No. 2, 01.08.2009, p. 568-573.Research output: Contribution to journal › Article
TY - JOUR
T1 - Association of apolipoprotein A5 concentration with serum insulin and triglyceride levels and coronary artery disease in Korean men
AU - Hyun, Yae Jung
AU - Jang, Yangsoo
AU - Chae, Jey Sook
AU - Kim, Ji Young
AU - Paik, Jean Kyung
AU - Kim, So Yeon
AU - Yang, Ju Young
AU - Ordovas, Jose M.
AU - Ko, Young Guk
AU - Lee, Jong Ho
PY - 2009/8/1
Y1 - 2009/8/1
N2 - Objective: Whereas the relation between apolipoprotein A5 (APOA5) gene polymorphisms and triglycerides (TG) levels is well established, the associations between apoA5 concentrations, TG and coronary artery disease (CAD) remain controversial. Therefore, we investigated these relations in the setting of a case-control study involving Korean males. Methods: ApoA5, TG, insulin, free fatty acid (FFA) and lipoprotein profiles were determined using a cross-sectional design in 777 healthy controls and 367 CAD patients. Results: Plasma apoA5 concentration was lower in CAD patients than controls (192.7 ± 5.2 vs. 237.2 ± 3.7 ng/ml, P < 0.001). Values in the second and top tertiles of apoA5 were associated with a decreased odds ratio (OR) for CAD when compared with values in the bottom tertile; OR for apoA5 top tertile was 0.33 (95% CI, 0.23-0.47) in the age- and BMI-adjusted model and 0.35 (95% CI, 0.23-0.56) following additional adjustments for smoking, drinking status, blood pressure, TG and HDL-cholesterol. After adjustment for age and BMI, plasma apoA5 concentration was negatively correlated with serum TG (r = -0.188, P < 0.001) and insulin (r = -0.185, P < 0.001) in normotriglyceridemic controls (TG < 150 mg/dL, n = 509) whereas apoA5 was positively correlated with serum TG in hypertriglyceridemic controls (TG ≥ 150 mg/dL, n = 268) (r = 0.246, P < 0.001) and total CAD patients (r = 0.177, P < 0.01). Regardless of TG levels and CAD status, apoA5 concentration was positively correlated with HDL-cholesterol and FFA levels. Conclusions: Our data supports an inverse association between plasma apoA5 concentrations and CAD risk, probably due to the observed negative correlations of apoA5 with TGs and insulin, although these correlations were affected by TG levels.
AB - Objective: Whereas the relation between apolipoprotein A5 (APOA5) gene polymorphisms and triglycerides (TG) levels is well established, the associations between apoA5 concentrations, TG and coronary artery disease (CAD) remain controversial. Therefore, we investigated these relations in the setting of a case-control study involving Korean males. Methods: ApoA5, TG, insulin, free fatty acid (FFA) and lipoprotein profiles were determined using a cross-sectional design in 777 healthy controls and 367 CAD patients. Results: Plasma apoA5 concentration was lower in CAD patients than controls (192.7 ± 5.2 vs. 237.2 ± 3.7 ng/ml, P < 0.001). Values in the second and top tertiles of apoA5 were associated with a decreased odds ratio (OR) for CAD when compared with values in the bottom tertile; OR for apoA5 top tertile was 0.33 (95% CI, 0.23-0.47) in the age- and BMI-adjusted model and 0.35 (95% CI, 0.23-0.56) following additional adjustments for smoking, drinking status, blood pressure, TG and HDL-cholesterol. After adjustment for age and BMI, plasma apoA5 concentration was negatively correlated with serum TG (r = -0.188, P < 0.001) and insulin (r = -0.185, P < 0.001) in normotriglyceridemic controls (TG < 150 mg/dL, n = 509) whereas apoA5 was positively correlated with serum TG in hypertriglyceridemic controls (TG ≥ 150 mg/dL, n = 268) (r = 0.246, P < 0.001) and total CAD patients (r = 0.177, P < 0.01). Regardless of TG levels and CAD status, apoA5 concentration was positively correlated with HDL-cholesterol and FFA levels. Conclusions: Our data supports an inverse association between plasma apoA5 concentrations and CAD risk, probably due to the observed negative correlations of apoA5 with TGs and insulin, although these correlations were affected by TG levels.
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U2 - 10.1016/j.atherosclerosis.2008.12.035
DO - 10.1016/j.atherosclerosis.2008.12.035
M3 - Article
C2 - 19185864
AN - SCOPUS:67651028357
VL - 205
SP - 568
EP - 573
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 2
ER -