Abstract
Several antecedent studies had reported close relationship between low body weight and Parkinson's disease (PD). However, there have been few investigations about the role of body weight to nigrostriatal dopaminergic neurodegeneration. This study enrolled 398 de novo patients with PD whom underwent [18F] N-(3-Fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane positron emission tomography scan and body mass index (BMI) measurement. The relationships between BMI and dopamine transporter (DAT) activity were analyzed using linear regression analysis. A multivariate analysis adjusted for age, gender, disease duration, smoking status, coffee and tea consumption, and residence area revealed that BMI remained independently and significantly associated with DAT activity in all striatal subregions. Moreover, multiple logistic regression analyses showed that BMI was a significant predictor for the lowest quartile of DAT activity in the anterior putamen, ventral striatum, caudate nucleus, and total striatum. The present findings suggest that a low BMI might be closely associated with low density of nigrostriatal dopaminergic neurons in PD, which could support the evidence for the role of low body weight to PD-related pathologies.
| Original language | English |
|---|---|
| Pages (from-to) | 197-204 |
| Number of pages | 8 |
| Journal | Neurobiology of Aging |
| Volume | 38 |
| DOIs | |
| Publication status | Published - 2016 Jan 1 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Neuroscience(all)
- Ageing
- Clinical Neurology
- Developmental Biology
- Geriatrics and Gerontology
Cite this
}
Association of body mass index and the depletion of nigrostriatal dopamine in Parkinson's disease. / Lee, Jae Jung; Oh, Jungsu S.; Ham, Jee H.; Lee, Dong H.; Lee, Injoo; Sohn, Young H.; Kim, Jae S.; Lee, philhyu.
In: Neurobiology of Aging, Vol. 38, 01.01.2016, p. 197-204.Research output: Contribution to journal › Article
TY - JOUR
T1 - Association of body mass index and the depletion of nigrostriatal dopamine in Parkinson's disease
AU - Lee, Jae Jung
AU - Oh, Jungsu S.
AU - Ham, Jee H.
AU - Lee, Dong H.
AU - Lee, Injoo
AU - Sohn, Young H.
AU - Kim, Jae S.
AU - Lee, philhyu
PY - 2016/1/1
Y1 - 2016/1/1
N2 - Several antecedent studies had reported close relationship between low body weight and Parkinson's disease (PD). However, there have been few investigations about the role of body weight to nigrostriatal dopaminergic neurodegeneration. This study enrolled 398 de novo patients with PD whom underwent [18F] N-(3-Fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane positron emission tomography scan and body mass index (BMI) measurement. The relationships between BMI and dopamine transporter (DAT) activity were analyzed using linear regression analysis. A multivariate analysis adjusted for age, gender, disease duration, smoking status, coffee and tea consumption, and residence area revealed that BMI remained independently and significantly associated with DAT activity in all striatal subregions. Moreover, multiple logistic regression analyses showed that BMI was a significant predictor for the lowest quartile of DAT activity in the anterior putamen, ventral striatum, caudate nucleus, and total striatum. The present findings suggest that a low BMI might be closely associated with low density of nigrostriatal dopaminergic neurons in PD, which could support the evidence for the role of low body weight to PD-related pathologies.
AB - Several antecedent studies had reported close relationship between low body weight and Parkinson's disease (PD). However, there have been few investigations about the role of body weight to nigrostriatal dopaminergic neurodegeneration. This study enrolled 398 de novo patients with PD whom underwent [18F] N-(3-Fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane positron emission tomography scan and body mass index (BMI) measurement. The relationships between BMI and dopamine transporter (DAT) activity were analyzed using linear regression analysis. A multivariate analysis adjusted for age, gender, disease duration, smoking status, coffee and tea consumption, and residence area revealed that BMI remained independently and significantly associated with DAT activity in all striatal subregions. Moreover, multiple logistic regression analyses showed that BMI was a significant predictor for the lowest quartile of DAT activity in the anterior putamen, ventral striatum, caudate nucleus, and total striatum. The present findings suggest that a low BMI might be closely associated with low density of nigrostriatal dopaminergic neurons in PD, which could support the evidence for the role of low body weight to PD-related pathologies.
UR - http://www.scopus.com/inward/record.url?scp=84962256676&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962256676&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2015.11.009
DO - 10.1016/j.neurobiolaging.2015.11.009
M3 - Article
C2 - 26827658
AN - SCOPUS:84962256676
VL - 38
SP - 197
EP - 204
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
ER -