Association of body mass index and the depletion of nigrostriatal dopamine in Parkinson's disease

Jae Jung Lee, Jungsu S. Oh, Jee H. Ham, Dong H. Lee, Injoo Lee, Young H. Sohn, Jae S. Kim, philhyu Lee

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Several antecedent studies had reported close relationship between low body weight and Parkinson's disease (PD). However, there have been few investigations about the role of body weight to nigrostriatal dopaminergic neurodegeneration. This study enrolled 398 de novo patients with PD whom underwent [18F] N-(3-Fluoropropyl)-2β-carbon ethoxy-3β-(4-iodophenyl) nortropane positron emission tomography scan and body mass index (BMI) measurement. The relationships between BMI and dopamine transporter (DAT) activity were analyzed using linear regression analysis. A multivariate analysis adjusted for age, gender, disease duration, smoking status, coffee and tea consumption, and residence area revealed that BMI remained independently and significantly associated with DAT activity in all striatal subregions. Moreover, multiple logistic regression analyses showed that BMI was a significant predictor for the lowest quartile of DAT activity in the anterior putamen, ventral striatum, caudate nucleus, and total striatum. The present findings suggest that a low BMI might be closely associated with low density of nigrostriatal dopaminergic neurons in PD, which could support the evidence for the role of low body weight to PD-related pathologies.

Original languageEnglish
Pages (from-to)197-204
Number of pages8
JournalNeurobiology of Aging
Volume38
DOIs
Publication statusPublished - 2016 Jan 1

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Parkinson Disease
Dopamine
Body Mass Index
Dopamine Plasma Membrane Transport Proteins
Body Weight
Nortropanes
Regression Analysis
Corpus Striatum
Caudate Nucleus
Dopaminergic Neurons
Putamen
Coffee
Tea
Positron-Emission Tomography
Linear Models
Carbon
Multivariate Analysis
Logistic Models
Smoking
Pathology

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Ageing
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

Cite this

Lee, Jae Jung ; Oh, Jungsu S. ; Ham, Jee H. ; Lee, Dong H. ; Lee, Injoo ; Sohn, Young H. ; Kim, Jae S. ; Lee, philhyu. / Association of body mass index and the depletion of nigrostriatal dopamine in Parkinson's disease. In: Neurobiology of Aging. 2016 ; Vol. 38. pp. 197-204.
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Association of body mass index and the depletion of nigrostriatal dopamine in Parkinson's disease. / Lee, Jae Jung; Oh, Jungsu S.; Ham, Jee H.; Lee, Dong H.; Lee, Injoo; Sohn, Young H.; Kim, Jae S.; Lee, philhyu.

In: Neurobiology of Aging, Vol. 38, 01.01.2016, p. 197-204.

Research output: Contribution to journalArticle

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