Abstract
Purpose: To evaluate the association of known prognostic factors with the BRAFV600E mutation and its association with ultrasonographic (US) features in Korean patients with papillary thyroid microcarcinoma (PTMC). Materials and Methods: This retrospective study was institutional review board approved; informed consent was not required from patients. From July 2008 to November 2008, 339 consecutive patients underwent surgery for PTMC. US-guided fineneedle aspiration biopsy was performed to evaluate BRAF status in thyroid nodules before surgery. Logistic regression analysis was performed to assess the association between BRAF status, determined by using clinicopathologic factors, and several US features. Results: Univariate analysis revealed an association between the BRAFV600E mutation and both tumor size and extracapsular invasion. Tumor size, extracapsular invasion, and high TNM stage (III and IV) were significantly associated with BRAFV600E in multivariate analysis. BRAFV600E was not significantly associated with any US features. Conclusion: The BRAFV600E mutation can be used as a potential prognostic factor in PTMC patients in a BRAFV600E-prevalent area. Future studies will be needed to determine how this information can be used to alter patient care.
| Original language | English |
|---|---|
| Pages (from-to) | 854-860 |
| Number of pages | 7 |
| Journal | Radiology |
| Volume | 253 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2009 Dec 1 |
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All Science Journal Classification (ASJC) codes
- Radiology Nuclear Medicine and imaging
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Association of BRAFV600E mutation with poor clinical prognostic factors and US features in Korean patients with papillary thyroid microcarcinoma. / Kwak, Jin Young; Kim, Eun Kyung; Chung, Woong Youn; Moon, Hee Jung; Kim, Min Jung; Choi, Jong Rak.
In: Radiology, Vol. 253, No. 3, 01.12.2009, p. 854-860.Research output: Contribution to journal › Article
TY - JOUR
T1 - Association of BRAFV600E mutation with poor clinical prognostic factors and US features in Korean patients with papillary thyroid microcarcinoma
AU - Kwak, Jin Young
AU - Kim, Eun Kyung
AU - Chung, Woong Youn
AU - Moon, Hee Jung
AU - Kim, Min Jung
AU - Choi, Jong Rak
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Purpose: To evaluate the association of known prognostic factors with the BRAFV600E mutation and its association with ultrasonographic (US) features in Korean patients with papillary thyroid microcarcinoma (PTMC). Materials and Methods: This retrospective study was institutional review board approved; informed consent was not required from patients. From July 2008 to November 2008, 339 consecutive patients underwent surgery for PTMC. US-guided fineneedle aspiration biopsy was performed to evaluate BRAF status in thyroid nodules before surgery. Logistic regression analysis was performed to assess the association between BRAF status, determined by using clinicopathologic factors, and several US features. Results: Univariate analysis revealed an association between the BRAFV600E mutation and both tumor size and extracapsular invasion. Tumor size, extracapsular invasion, and high TNM stage (III and IV) were significantly associated with BRAFV600E in multivariate analysis. BRAFV600E was not significantly associated with any US features. Conclusion: The BRAFV600E mutation can be used as a potential prognostic factor in PTMC patients in a BRAFV600E-prevalent area. Future studies will be needed to determine how this information can be used to alter patient care.
AB - Purpose: To evaluate the association of known prognostic factors with the BRAFV600E mutation and its association with ultrasonographic (US) features in Korean patients with papillary thyroid microcarcinoma (PTMC). Materials and Methods: This retrospective study was institutional review board approved; informed consent was not required from patients. From July 2008 to November 2008, 339 consecutive patients underwent surgery for PTMC. US-guided fineneedle aspiration biopsy was performed to evaluate BRAF status in thyroid nodules before surgery. Logistic regression analysis was performed to assess the association between BRAF status, determined by using clinicopathologic factors, and several US features. Results: Univariate analysis revealed an association between the BRAFV600E mutation and both tumor size and extracapsular invasion. Tumor size, extracapsular invasion, and high TNM stage (III and IV) were significantly associated with BRAFV600E in multivariate analysis. BRAFV600E was not significantly associated with any US features. Conclusion: The BRAFV600E mutation can be used as a potential prognostic factor in PTMC patients in a BRAFV600E-prevalent area. Future studies will be needed to determine how this information can be used to alter patient care.
UR - http://www.scopus.com/inward/record.url?scp=73949139889&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=73949139889&partnerID=8YFLogxK
U2 - 10.1148/radiol.2533090471
DO - 10.1148/radiol.2533090471
M3 - Article
C2 - 19710001
AN - SCOPUS:73949139889
VL - 253
SP - 854
EP - 860
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 3
ER -