Association of BRAFV600E mutation with poor clinical prognostic factors and US features in Korean patients with papillary thyroid microcarcinoma

Jin Young Kwak, Eun Kyung Kim, Woong Youn Chung, Hee Jung Moon, Min Jung Kim, Jong Rak Choi

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Purpose: To evaluate the association of known prognostic factors with the BRAFV600E mutation and its association with ultrasonographic (US) features in Korean patients with papillary thyroid microcarcinoma (PTMC). Materials and Methods: This retrospective study was institutional review board approved; informed consent was not required from patients. From July 2008 to November 2008, 339 consecutive patients underwent surgery for PTMC. US-guided fineneedle aspiration biopsy was performed to evaluate BRAF status in thyroid nodules before surgery. Logistic regression analysis was performed to assess the association between BRAF status, determined by using clinicopathologic factors, and several US features. Results: Univariate analysis revealed an association between the BRAFV600E mutation and both tumor size and extracapsular invasion. Tumor size, extracapsular invasion, and high TNM stage (III and IV) were significantly associated with BRAFV600E in multivariate analysis. BRAFV600E was not significantly associated with any US features. Conclusion: The BRAFV600E mutation can be used as a potential prognostic factor in PTMC patients in a BRAFV600E-prevalent area. Future studies will be needed to determine how this information can be used to alter patient care.

Original languageEnglish
Pages (from-to)854-860
Number of pages7
JournalRadiology
Volume253
Issue number3
DOIs
Publication statusPublished - 2009 Dec 1

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Mutation
Thyroid Nodule
Research Ethics Committees
Needle Biopsy
Informed Consent
Neoplasms
Patient Care
Multivariate Analysis
Retrospective Studies
Logistic Models
Regression Analysis
Papillary Thyroid Microcarcinoma

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Association of BRAFV600E mutation with poor clinical prognostic factors and US features in Korean patients with papillary thyroid microcarcinoma",
abstract = "Purpose: To evaluate the association of known prognostic factors with the BRAFV600E mutation and its association with ultrasonographic (US) features in Korean patients with papillary thyroid microcarcinoma (PTMC). Materials and Methods: This retrospective study was institutional review board approved; informed consent was not required from patients. From July 2008 to November 2008, 339 consecutive patients underwent surgery for PTMC. US-guided fineneedle aspiration biopsy was performed to evaluate BRAF status in thyroid nodules before surgery. Logistic regression analysis was performed to assess the association between BRAF status, determined by using clinicopathologic factors, and several US features. Results: Univariate analysis revealed an association between the BRAFV600E mutation and both tumor size and extracapsular invasion. Tumor size, extracapsular invasion, and high TNM stage (III and IV) were significantly associated with BRAFV600E in multivariate analysis. BRAFV600E was not significantly associated with any US features. Conclusion: The BRAFV600E mutation can be used as a potential prognostic factor in PTMC patients in a BRAFV600E-prevalent area. Future studies will be needed to determine how this information can be used to alter patient care.",
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Association of BRAFV600E mutation with poor clinical prognostic factors and US features in Korean patients with papillary thyroid microcarcinoma. / Kwak, Jin Young; Kim, Eun Kyung; Chung, Woong Youn; Moon, Hee Jung; Kim, Min Jung; Choi, Jong Rak.

In: Radiology, Vol. 253, No. 3, 01.12.2009, p. 854-860.

Research output: Contribution to journalArticle

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AU - Kim, Min Jung

AU - Choi, Jong Rak

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