Association of CCR2 polymorphisms with the number of closed coronary artery vessels in coronary artery disease

Seung Hun Cha; Jong Keuk Lee; Jong Young Lee; Hung Tae Kim; Ha Jung Ryu; Bok Ghee Han; Jun Woo Kim; Bermseok Oh; Kuchan Kimm; Hyung Doo Shin; Byung Lae Park; Sungha Park; Hyun Young Park; Yangsoo Jang

doi:10.1016/j.cca.2007.03.017

Association of CCR2 polymorphisms with the number of closed coronary artery vessels in coronary artery disease

Seung Hun Cha, Jong Keuk Lee, Jong Young Lee, Hung Tae Kim, Ha Jung Ryu, Bok Ghee Han, Jun Woo Kim, Bermseok Oh, Kuchan Kimm, Hyung Doo Shin, Byung Lae Park, Sungha Park, Hyun Young Park, Yangsoo Jang

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Coronary artery disease (CAD) is one of the most common forms of heart disease. It has been demonstrated that chemokine-mediated inflammation is associated with the development of CAD. In this study, in order to determine the role of CCR2, a receptor for MCP-1, in the development of CAD, we initially sequenced and identified the genetic variants of CCR2 using 24 unrelated Korean individuals' DNA samples. A total of 13 genetic variants, including 1 deletion and 12 SNPs, were identified in the Korean population. Although we could not detect any association of CCR2 polymorphic markers with CAD, several SNP markers of CCR2 gene showed highly significant signals with the number of arteries with significant coronary artery stenosis in the CAD male patients. The most significant signal was detected at the SNP located at exon 2 (+ 780T > C, Asn260Asn) CI: 1.19-1.87, P = 0.0005 (odds ratio: 1.49, 95% CI: 1.19-1.87, p = 0.0005) (Table 3). This result indicates that CCR2 can play a role in the pathogenesis of CAD, especially to the number of vessels in CAD.

Original language	English
Pages (from-to)	129-133
Number of pages	5
Journal	Clinica Chimica Acta
Volume	382
Issue number	1-2
DOIs	https://doi.org/10.1016/j.cca.2007.03.017
Publication status	Published - 2007 Jul

Bibliographical note

Funding Information:
The study subjects included 750 male consecutive patients with symptomatic coronary artery disease who underwent coronary angiography at Yonsei Cardiovascular Hospital between January of 2004 and April of 2005. 717 male patients without evidence of significant coronary artery disease, demonstrated by treadmill test, stress MIBI scan or coronary angiography, were used as the control population. All the patients in the study were enrolled in the Cardiovascular Genome Center of Yonsei University, a government sponsored project supported by the Ministry of Health and Welfare, Republic of Korea.

Funding Information:
This work was supported by the intramural grant of the National Institute of Health, Korea.

All Science Journal Classification (ASJC) codes

Biochemistry
Clinical Biochemistry
Biochemistry, medical

Access to Document

10.1016/j.cca.2007.03.017

Cite this

@article{801800447dcb48249f94683927e7f5bb,

title = "Association of CCR2 polymorphisms with the number of closed coronary artery vessels in coronary artery disease",

abstract = "Coronary artery disease (CAD) is one of the most common forms of heart disease. It has been demonstrated that chemokine-mediated inflammation is associated with the development of CAD. In this study, in order to determine the role of CCR2, a receptor for MCP-1, in the development of CAD, we initially sequenced and identified the genetic variants of CCR2 using 24 unrelated Korean individuals' DNA samples. A total of 13 genetic variants, including 1 deletion and 12 SNPs, were identified in the Korean population. Although we could not detect any association of CCR2 polymorphic markers with CAD, several SNP markers of CCR2 gene showed highly significant signals with the number of arteries with significant coronary artery stenosis in the CAD male patients. The most significant signal was detected at the SNP located at exon 2 (+ 780T > C, Asn260Asn) CI: 1.19-1.87, P = 0.0005 (odds ratio: 1.49, 95% CI: 1.19-1.87, p = 0.0005) (Table 3). This result indicates that CCR2 can play a role in the pathogenesis of CAD, especially to the number of vessels in CAD.",

author = "Cha, {Seung Hun} and Lee, {Jong Keuk} and Lee, {Jong Young} and Kim, {Hung Tae} and Ryu, {Ha Jung} and Han, {Bok Ghee} and Kim, {Jun Woo} and Bermseok Oh and Kuchan Kimm and Shin, {Hyung Doo} and Park, {Byung Lae} and Sungha Park and Park, {Hyun Young} and Yangsoo Jang",

note = "Funding Information: The study subjects included 750 male consecutive patients with symptomatic coronary artery disease who underwent coronary angiography at Yonsei Cardiovascular Hospital between January of 2004 and April of 2005. 717 male patients without evidence of significant coronary artery disease, demonstrated by treadmill test, stress MIBI scan or coronary angiography, were used as the control population. All the patients in the study were enrolled in the Cardiovascular Genome Center of Yonsei University, a government sponsored project supported by the Ministry of Health and Welfare, Republic of Korea. Funding Information: This work was supported by the intramural grant of the National Institute of Health, Korea. ",

year = "2007",

month = jul,

doi = "10.1016/j.cca.2007.03.017",

language = "English",

volume = "382",

pages = "129--133",

journal = "Clinica Chimica Acta",

issn = "0009-8981",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - Association of CCR2 polymorphisms with the number of closed coronary artery vessels in coronary artery disease

AU - Cha, Seung Hun

AU - Lee, Jong Keuk

AU - Lee, Jong Young

AU - Kim, Hung Tae

AU - Ryu, Ha Jung

AU - Han, Bok Ghee

AU - Kim, Jun Woo

AU - Oh, Bermseok

AU - Kimm, Kuchan

AU - Shin, Hyung Doo

AU - Park, Byung Lae

AU - Park, Sungha

AU - Park, Hyun Young

AU - Jang, Yangsoo

N1 - Funding Information: The study subjects included 750 male consecutive patients with symptomatic coronary artery disease who underwent coronary angiography at Yonsei Cardiovascular Hospital between January of 2004 and April of 2005. 717 male patients without evidence of significant coronary artery disease, demonstrated by treadmill test, stress MIBI scan or coronary angiography, were used as the control population. All the patients in the study were enrolled in the Cardiovascular Genome Center of Yonsei University, a government sponsored project supported by the Ministry of Health and Welfare, Republic of Korea. Funding Information: This work was supported by the intramural grant of the National Institute of Health, Korea.

PY - 2007/7

Y1 - 2007/7

N2 - Coronary artery disease (CAD) is one of the most common forms of heart disease. It has been demonstrated that chemokine-mediated inflammation is associated with the development of CAD. In this study, in order to determine the role of CCR2, a receptor for MCP-1, in the development of CAD, we initially sequenced and identified the genetic variants of CCR2 using 24 unrelated Korean individuals' DNA samples. A total of 13 genetic variants, including 1 deletion and 12 SNPs, were identified in the Korean population. Although we could not detect any association of CCR2 polymorphic markers with CAD, several SNP markers of CCR2 gene showed highly significant signals with the number of arteries with significant coronary artery stenosis in the CAD male patients. The most significant signal was detected at the SNP located at exon 2 (+ 780T > C, Asn260Asn) CI: 1.19-1.87, P = 0.0005 (odds ratio: 1.49, 95% CI: 1.19-1.87, p = 0.0005) (Table 3). This result indicates that CCR2 can play a role in the pathogenesis of CAD, especially to the number of vessels in CAD.

AB - Coronary artery disease (CAD) is one of the most common forms of heart disease. It has been demonstrated that chemokine-mediated inflammation is associated with the development of CAD. In this study, in order to determine the role of CCR2, a receptor for MCP-1, in the development of CAD, we initially sequenced and identified the genetic variants of CCR2 using 24 unrelated Korean individuals' DNA samples. A total of 13 genetic variants, including 1 deletion and 12 SNPs, were identified in the Korean population. Although we could not detect any association of CCR2 polymorphic markers with CAD, several SNP markers of CCR2 gene showed highly significant signals with the number of arteries with significant coronary artery stenosis in the CAD male patients. The most significant signal was detected at the SNP located at exon 2 (+ 780T > C, Asn260Asn) CI: 1.19-1.87, P = 0.0005 (odds ratio: 1.49, 95% CI: 1.19-1.87, p = 0.0005) (Table 3). This result indicates that CCR2 can play a role in the pathogenesis of CAD, especially to the number of vessels in CAD.

UR - http://www.scopus.com/inward/record.url?scp=34249328539&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34249328539&partnerID=8YFLogxK

U2 - 10.1016/j.cca.2007.03.017

DO - 10.1016/j.cca.2007.03.017

M3 - Article

C2 - 17482150

AN - SCOPUS:34249328539

SN - 0009-8981

VL - 382

SP - 129

EP - 133

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

IS - 1-2

ER -

Association of CCR2 polymorphisms with the number of closed coronary artery vessels in coronary artery disease

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this