Coronary artery disease (CAD) is one of the most common forms of heart disease. It has been demonstrated that chemokine-mediated inflammation is associated with the development of CAD. In this study, in order to determine the role of CCR2, a receptor for MCP-1, in the development of CAD, we initially sequenced and identified the genetic variants of CCR2 using 24 unrelated Korean individuals' DNA samples. A total of 13 genetic variants, including 1 deletion and 12 SNPs, were identified in the Korean population. Although we could not detect any association of CCR2 polymorphic markers with CAD, several SNP markers of CCR2 gene showed highly significant signals with the number of arteries with significant coronary artery stenosis in the CAD male patients. The most significant signal was detected at the SNP located at exon 2 (+ 780T > C, Asn260Asn) CI: 1.19-1.87, P = 0.0005 (odds ratio: 1.49, 95% CI: 1.19-1.87, p = 0.0005) (Table 3). This result indicates that CCR2 can play a role in the pathogenesis of CAD, especially to the number of vessels in CAD.
Bibliographical noteFunding Information:
The study subjects included 750 male consecutive patients with symptomatic coronary artery disease who underwent coronary angiography at Yonsei Cardiovascular Hospital between January of 2004 and April of 2005. 717 male patients without evidence of significant coronary artery disease, demonstrated by treadmill test, stress MIBI scan or coronary angiography, were used as the control population. All the patients in the study were enrolled in the Cardiovascular Genome Center of Yonsei University, a government sponsored project supported by the Ministry of Health and Welfare, Republic of Korea.
This work was supported by the intramural grant of the National Institute of Health, Korea.
All Science Journal Classification (ASJC) codes
- Clinical Biochemistry
- Biochemistry, medical