Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea

Eun Seok Kang, Myoung Soo Kim, Chul Hoon Kim, Chung Mo Nam, Seung Jin Han, Kyu Yeon Hur, Chul Woo Ahn, Bong Soo Cha, Soon Il Kim, Hyun Chul Lee, Yu Seun Kim

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Abstract

Background. Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Recent genome-wide association studies have identified several genes associated with type 2 diabetes. Here, we examined the association between PTDM and 17 single nucleotide polymorphisms (SNPs) located within 15 genes in a cohort of renal allograft recipients in Korea. Materials and Methods. A total of 589 patients who received kidney transplants between 1989 and 2007, without a history of diabetes and had a pretransplant fasting glucose less than. 5.5 mmol/L were included in this study. We analyzed the association between the PTDM development and the following SNPs: TCF7L2 rs7903146, SLC30A8 rsl3266634, HHEX (rs1111875, rs7923837, and rs5015480), CDKAL1 rs10946398, CDKN2A/B rs10811661, IGF2BP2 rs4402960, FTO rs8050136, WFS1 rs734312, JAZF1 rs864745, CDC123/CAMK1D rs12779790, TSPAN8 rs7961581, THADA rs7578597, ADAMTS9 rs4607103, NOTCH2 rs1092391, and KCNQ1 rs2237892. Results. Eight SNPs in six genes were significantly associated with the PTDM development: TCF7L2 rs7903146 (odds ratio [OR]=2.20, P=0.016), SLC30A8 rsl.3266634 (OR=1.52, P=0.003), HHEX rs1111875 (OR=1.47, P=0.007), HHEX rs7923837 (OR=2.32, P=0.014), HHEX rs5015480 (OR= 1.59, P=0.003), CDKAL1 rs10946398 (OR= 1.43, P=0.008), CDKN2A/B rs10811661 (OR= 1.33, P=0.039), and KCNQ1 rs2237892 (OR=1.46, P=0.009). Conclusions. These data suggest that genetic variations in TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, and KCNQ1 are associated with PTDM in Korea.

Original languageEnglish
Pages (from-to)693-698
Number of pages6
JournalTransplantation
Volume88
Issue number5
DOIs
Publication statusPublished - 2009 Sep 15

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Korea
Type 2 Diabetes Mellitus
Allografts
Diabetes Mellitus
Odds Ratio
Kidney
Genes
Single Nucleotide Polymorphism
Genome-Wide Association Study
Fasting
Transplants
Glucose

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Kang, Eun Seok ; Kim, Myoung Soo ; Kim, Chul Hoon ; Nam, Chung Mo ; Han, Seung Jin ; Hur, Kyu Yeon ; Ahn, Chul Woo ; Cha, Bong Soo ; Kim, Soon Il ; Lee, Hyun Chul ; Kim, Yu Seun. / Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea. In: Transplantation. 2009 ; Vol. 88, No. 5. pp. 693-698.
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title = "Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea",
abstract = "Background. Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Recent genome-wide association studies have identified several genes associated with type 2 diabetes. Here, we examined the association between PTDM and 17 single nucleotide polymorphisms (SNPs) located within 15 genes in a cohort of renal allograft recipients in Korea. Materials and Methods. A total of 589 patients who received kidney transplants between 1989 and 2007, without a history of diabetes and had a pretransplant fasting glucose less than. 5.5 mmol/L were included in this study. We analyzed the association between the PTDM development and the following SNPs: TCF7L2 rs7903146, SLC30A8 rsl3266634, HHEX (rs1111875, rs7923837, and rs5015480), CDKAL1 rs10946398, CDKN2A/B rs10811661, IGF2BP2 rs4402960, FTO rs8050136, WFS1 rs734312, JAZF1 rs864745, CDC123/CAMK1D rs12779790, TSPAN8 rs7961581, THADA rs7578597, ADAMTS9 rs4607103, NOTCH2 rs1092391, and KCNQ1 rs2237892. Results. Eight SNPs in six genes were significantly associated with the PTDM development: TCF7L2 rs7903146 (odds ratio [OR]=2.20, P=0.016), SLC30A8 rsl.3266634 (OR=1.52, P=0.003), HHEX rs1111875 (OR=1.47, P=0.007), HHEX rs7923837 (OR=2.32, P=0.014), HHEX rs5015480 (OR= 1.59, P=0.003), CDKAL1 rs10946398 (OR= 1.43, P=0.008), CDKN2A/B rs10811661 (OR= 1.33, P=0.039), and KCNQ1 rs2237892 (OR=1.46, P=0.009). Conclusions. These data suggest that genetic variations in TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, and KCNQ1 are associated with PTDM in Korea.",
author = "Kang, {Eun Seok} and Kim, {Myoung Soo} and Kim, {Chul Hoon} and Nam, {Chung Mo} and Han, {Seung Jin} and Hur, {Kyu Yeon} and Ahn, {Chul Woo} and Cha, {Bong Soo} and Kim, {Soon Il} and Lee, {Hyun Chul} and Kim, {Yu Seun}",
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Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea. / Kang, Eun Seok; Kim, Myoung Soo; Kim, Chul Hoon; Nam, Chung Mo; Han, Seung Jin; Hur, Kyu Yeon; Ahn, Chul Woo; Cha, Bong Soo; Kim, Soon Il; Lee, Hyun Chul; Kim, Yu Seun.

In: Transplantation, Vol. 88, No. 5, 15.09.2009, p. 693-698.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea

AU - Kang, Eun Seok

AU - Kim, Myoung Soo

AU - Kim, Chul Hoon

AU - Nam, Chung Mo

AU - Han, Seung Jin

AU - Hur, Kyu Yeon

AU - Ahn, Chul Woo

AU - Cha, Bong Soo

AU - Kim, Soon Il

AU - Lee, Hyun Chul

AU - Kim, Yu Seun

PY - 2009/9/15

Y1 - 2009/9/15

N2 - Background. Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Recent genome-wide association studies have identified several genes associated with type 2 diabetes. Here, we examined the association between PTDM and 17 single nucleotide polymorphisms (SNPs) located within 15 genes in a cohort of renal allograft recipients in Korea. Materials and Methods. A total of 589 patients who received kidney transplants between 1989 and 2007, without a history of diabetes and had a pretransplant fasting glucose less than. 5.5 mmol/L were included in this study. We analyzed the association between the PTDM development and the following SNPs: TCF7L2 rs7903146, SLC30A8 rsl3266634, HHEX (rs1111875, rs7923837, and rs5015480), CDKAL1 rs10946398, CDKN2A/B rs10811661, IGF2BP2 rs4402960, FTO rs8050136, WFS1 rs734312, JAZF1 rs864745, CDC123/CAMK1D rs12779790, TSPAN8 rs7961581, THADA rs7578597, ADAMTS9 rs4607103, NOTCH2 rs1092391, and KCNQ1 rs2237892. Results. Eight SNPs in six genes were significantly associated with the PTDM development: TCF7L2 rs7903146 (odds ratio [OR]=2.20, P=0.016), SLC30A8 rsl.3266634 (OR=1.52, P=0.003), HHEX rs1111875 (OR=1.47, P=0.007), HHEX rs7923837 (OR=2.32, P=0.014), HHEX rs5015480 (OR= 1.59, P=0.003), CDKAL1 rs10946398 (OR= 1.43, P=0.008), CDKN2A/B rs10811661 (OR= 1.33, P=0.039), and KCNQ1 rs2237892 (OR=1.46, P=0.009). Conclusions. These data suggest that genetic variations in TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, and KCNQ1 are associated with PTDM in Korea.

AB - Background. Posttransplantation diabetes mellitus (PTDM) is a major metabolic complication in renal transplant recipients. Recent genome-wide association studies have identified several genes associated with type 2 diabetes. Here, we examined the association between PTDM and 17 single nucleotide polymorphisms (SNPs) located within 15 genes in a cohort of renal allograft recipients in Korea. Materials and Methods. A total of 589 patients who received kidney transplants between 1989 and 2007, without a history of diabetes and had a pretransplant fasting glucose less than. 5.5 mmol/L were included in this study. We analyzed the association between the PTDM development and the following SNPs: TCF7L2 rs7903146, SLC30A8 rsl3266634, HHEX (rs1111875, rs7923837, and rs5015480), CDKAL1 rs10946398, CDKN2A/B rs10811661, IGF2BP2 rs4402960, FTO rs8050136, WFS1 rs734312, JAZF1 rs864745, CDC123/CAMK1D rs12779790, TSPAN8 rs7961581, THADA rs7578597, ADAMTS9 rs4607103, NOTCH2 rs1092391, and KCNQ1 rs2237892. Results. Eight SNPs in six genes were significantly associated with the PTDM development: TCF7L2 rs7903146 (odds ratio [OR]=2.20, P=0.016), SLC30A8 rsl.3266634 (OR=1.52, P=0.003), HHEX rs1111875 (OR=1.47, P=0.007), HHEX rs7923837 (OR=2.32, P=0.014), HHEX rs5015480 (OR= 1.59, P=0.003), CDKAL1 rs10946398 (OR= 1.43, P=0.008), CDKN2A/B rs10811661 (OR= 1.33, P=0.039), and KCNQ1 rs2237892 (OR=1.46, P=0.009). Conclusions. These data suggest that genetic variations in TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, and KCNQ1 are associated with PTDM in Korea.

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