Association of Depressive Symptoms and Micronutrient Deficiency with Cardiac Event-Free Survival in Patients with Heart Failure

Eun Kyeung Song, Debra K. Moser, seokmin kang, Terry A. Lennie

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background Depressive symptoms and malnutrition independently predict cardiac events in heart failure (HF) patients. However, the relationships among depressive symptoms, nutritional intake, and cardiac event-free survival have not been examined. Methods and Results A total of 232 patients with HF completed the Patient Health Questionnaire 9 (PHQ-9) to measure depressive symptoms and a 3-day food diary to determine the number of micronutrient deficiencies. Patients were followed for 2 years to collect data on cardiac event-free survival. Patients were divided into 4 groups by a PHQ-9 score of 10 and the median value of micronutrient deficiencies. Cox regressions were used to determine the relationships among depressive symptoms, micronutrient deficiency, and cardiac event-free survival. Depressive symptoms conferred greater risk of cardiac events in patients with a high number of micronutrient deficiencies than in those with a low number of micronutrient deficiencies. Patients with a PHQ-9 score ≥10 and number of micronutrient deficiencies >5 had 2.4 times higher risk for cardiac events compared with patients with a PHQ-9 score <10 and micronutrient deficiency ≤5 (P =.005). Conclusions There was a synergistic effect on the association of depressive symptoms with cardiac event-free survival in HF patients that differed by micronutrient deficiency.

Original languageEnglish
Pages (from-to)945-951
Number of pages7
JournalJournal of Cardiac Failure
Volume21
Issue number12
DOIs
Publication statusPublished - 2015 Dec 1

Fingerprint

Micronutrients
Disease-Free Survival
Heart Failure
Depression
Health
Diet Records
Malnutrition

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

@article{0a8a688a612949ff8f12c5270397d594,
title = "Association of Depressive Symptoms and Micronutrient Deficiency with Cardiac Event-Free Survival in Patients with Heart Failure",
abstract = "Background Depressive symptoms and malnutrition independently predict cardiac events in heart failure (HF) patients. However, the relationships among depressive symptoms, nutritional intake, and cardiac event-free survival have not been examined. Methods and Results A total of 232 patients with HF completed the Patient Health Questionnaire 9 (PHQ-9) to measure depressive symptoms and a 3-day food diary to determine the number of micronutrient deficiencies. Patients were followed for 2 years to collect data on cardiac event-free survival. Patients were divided into 4 groups by a PHQ-9 score of 10 and the median value of micronutrient deficiencies. Cox regressions were used to determine the relationships among depressive symptoms, micronutrient deficiency, and cardiac event-free survival. Depressive symptoms conferred greater risk of cardiac events in patients with a high number of micronutrient deficiencies than in those with a low number of micronutrient deficiencies. Patients with a PHQ-9 score ≥10 and number of micronutrient deficiencies >5 had 2.4 times higher risk for cardiac events compared with patients with a PHQ-9 score <10 and micronutrient deficiency ≤5 (P =.005). Conclusions There was a synergistic effect on the association of depressive symptoms with cardiac event-free survival in HF patients that differed by micronutrient deficiency.",
author = "Song, {Eun Kyeung} and Moser, {Debra K.} and seokmin kang and Lennie, {Terry A.}",
year = "2015",
month = "12",
day = "1",
doi = "10.1016/j.cardfail.2015.10.007",
language = "English",
volume = "21",
pages = "945--951",
journal = "Journal of Cardiac Failure",
issn = "1071-9164",
publisher = "Churchill Livingstone",
number = "12",

}

Association of Depressive Symptoms and Micronutrient Deficiency with Cardiac Event-Free Survival in Patients with Heart Failure. / Song, Eun Kyeung; Moser, Debra K.; kang, seokmin; Lennie, Terry A.

In: Journal of Cardiac Failure, Vol. 21, No. 12, 01.12.2015, p. 945-951.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of Depressive Symptoms and Micronutrient Deficiency with Cardiac Event-Free Survival in Patients with Heart Failure

AU - Song, Eun Kyeung

AU - Moser, Debra K.

AU - kang, seokmin

AU - Lennie, Terry A.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Background Depressive symptoms and malnutrition independently predict cardiac events in heart failure (HF) patients. However, the relationships among depressive symptoms, nutritional intake, and cardiac event-free survival have not been examined. Methods and Results A total of 232 patients with HF completed the Patient Health Questionnaire 9 (PHQ-9) to measure depressive symptoms and a 3-day food diary to determine the number of micronutrient deficiencies. Patients were followed for 2 years to collect data on cardiac event-free survival. Patients were divided into 4 groups by a PHQ-9 score of 10 and the median value of micronutrient deficiencies. Cox regressions were used to determine the relationships among depressive symptoms, micronutrient deficiency, and cardiac event-free survival. Depressive symptoms conferred greater risk of cardiac events in patients with a high number of micronutrient deficiencies than in those with a low number of micronutrient deficiencies. Patients with a PHQ-9 score ≥10 and number of micronutrient deficiencies >5 had 2.4 times higher risk for cardiac events compared with patients with a PHQ-9 score <10 and micronutrient deficiency ≤5 (P =.005). Conclusions There was a synergistic effect on the association of depressive symptoms with cardiac event-free survival in HF patients that differed by micronutrient deficiency.

AB - Background Depressive symptoms and malnutrition independently predict cardiac events in heart failure (HF) patients. However, the relationships among depressive symptoms, nutritional intake, and cardiac event-free survival have not been examined. Methods and Results A total of 232 patients with HF completed the Patient Health Questionnaire 9 (PHQ-9) to measure depressive symptoms and a 3-day food diary to determine the number of micronutrient deficiencies. Patients were followed for 2 years to collect data on cardiac event-free survival. Patients were divided into 4 groups by a PHQ-9 score of 10 and the median value of micronutrient deficiencies. Cox regressions were used to determine the relationships among depressive symptoms, micronutrient deficiency, and cardiac event-free survival. Depressive symptoms conferred greater risk of cardiac events in patients with a high number of micronutrient deficiencies than in those with a low number of micronutrient deficiencies. Patients with a PHQ-9 score ≥10 and number of micronutrient deficiencies >5 had 2.4 times higher risk for cardiac events compared with patients with a PHQ-9 score <10 and micronutrient deficiency ≤5 (P =.005). Conclusions There was a synergistic effect on the association of depressive symptoms with cardiac event-free survival in HF patients that differed by micronutrient deficiency.

UR - http://www.scopus.com/inward/record.url?scp=84960803027&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960803027&partnerID=8YFLogxK

U2 - 10.1016/j.cardfail.2015.10.007

DO - 10.1016/j.cardfail.2015.10.007

M3 - Article

VL - 21

SP - 945

EP - 951

JO - Journal of Cardiac Failure

JF - Journal of Cardiac Failure

SN - 1071-9164

IS - 12

ER -