Association of fatty acid composition in serum phospholipids with metabolic syndrome and arterial stiffness

O. Y. Kim, H. H. Lim, M. J. Lee, J. Y. Kim, J. H. Lee

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Background and aim: We examined the association of fatty acid (FA) composition in serum phospholipids with the features of metabolic syndrome (MetS) and arterial stiffness. Methods: Korean men (n= 593, 30-79yrs) were categorized based on the number of MetS risk factors (RFs) and measured for the markers of MetS, serum phospholipid FA composition and brachial-ankle pulse wave velocity (baPWV), an index for the severity of arterial stiffness. Results: Insulin resistance (HOMA-IR), baPWV, LDL size, and adiponectin were significantly altered corresponding to the number of MetS RFs. The proportions of total monounsaturated FA, palmitoleic acid (16:1), oleic acid (18:1ω-9) and dihomo-γ-linolenic acid (DGLA, 20:3ω-6) in serum phospholipids, and DGLA/linoleic acid (LA) (20:3ω-6/18:2ω-6), deta9-desaturase activity (D9D-16: 16:1/16:0 and D9D-18: 18:1ω-9/18:0) significantly increased corresponding to the number of MetS RFs, but D5D (20:4ω-6/20:3ω-6) decreased. baPWV positively correlated with HOMA-IR, palmitic acid (16:0), oleic acid, D6D (18:3ω-6/18:2ω-6), DGLA/LA and D9D-18, and negatively with adiponectin, LDL size, LA, docosahexaenoic acid (DHA, 22:6ω-3) and D5D. Multiple stepwise regression models revealed that baPWV was significantly influenced by systolic blood pressure, age, body weight, triglyceride and LA in serum phospholipids (R2=0.378). Interestingly, baPWV (1419±1cm/s) and MetS (22%) were highest in individuals with lower proportion of LA (<12.361%) and higher proportion of DGLA (≥1.412%) in serum phospholipid FAs. Conclusion: The features of MetS significantly related to serum phosopholipid FA composition. Particularly, arterial stiffness was associated with LA additively together with DLGA. It may suggest a potential benefit of sufficient amounts of LA in serum or in diet can reduce cardiovascular risk.

Original languageEnglish
Pages (from-to)366-374
Number of pages9
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume23
Issue number4
DOIs
Publication statusPublished - 2013 Apr 1

Fingerprint

Vascular Stiffness
Linoleic Acid
Pulse Wave Analysis
Phospholipids
Fatty Acids
Ankle
Arm
Serum
Adiponectin
Oleic Acid
Blood Pressure
Monounsaturated Fatty Acids
alpha-Linolenic Acid
Palmitic Acid
Docosahexaenoic Acids
Insulin Resistance
Triglycerides
Body Weight
Diet

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine

Cite this

@article{640dcf5834484b1ebe225505f98a0927,
title = "Association of fatty acid composition in serum phospholipids with metabolic syndrome and arterial stiffness",
abstract = "Background and aim: We examined the association of fatty acid (FA) composition in serum phospholipids with the features of metabolic syndrome (MetS) and arterial stiffness. Methods: Korean men (n= 593, 30-79yrs) were categorized based on the number of MetS risk factors (RFs) and measured for the markers of MetS, serum phospholipid FA composition and brachial-ankle pulse wave velocity (baPWV), an index for the severity of arterial stiffness. Results: Insulin resistance (HOMA-IR), baPWV, LDL size, and adiponectin were significantly altered corresponding to the number of MetS RFs. The proportions of total monounsaturated FA, palmitoleic acid (16:1), oleic acid (18:1ω-9) and dihomo-γ-linolenic acid (DGLA, 20:3ω-6) in serum phospholipids, and DGLA/linoleic acid (LA) (20:3ω-6/18:2ω-6), deta9-desaturase activity (D9D-16: 16:1/16:0 and D9D-18: 18:1ω-9/18:0) significantly increased corresponding to the number of MetS RFs, but D5D (20:4ω-6/20:3ω-6) decreased. baPWV positively correlated with HOMA-IR, palmitic acid (16:0), oleic acid, D6D (18:3ω-6/18:2ω-6), DGLA/LA and D9D-18, and negatively with adiponectin, LDL size, LA, docosahexaenoic acid (DHA, 22:6ω-3) and D5D. Multiple stepwise regression models revealed that baPWV was significantly influenced by systolic blood pressure, age, body weight, triglyceride and LA in serum phospholipids (R2=0.378). Interestingly, baPWV (1419±1cm/s) and MetS (22{\%}) were highest in individuals with lower proportion of LA (<12.361{\%}) and higher proportion of DGLA (≥1.412{\%}) in serum phospholipid FAs. Conclusion: The features of MetS significantly related to serum phosopholipid FA composition. Particularly, arterial stiffness was associated with LA additively together with DLGA. It may suggest a potential benefit of sufficient amounts of LA in serum or in diet can reduce cardiovascular risk.",
author = "Kim, {O. Y.} and Lim, {H. H.} and Lee, {M. J.} and Kim, {J. Y.} and Lee, {J. H.}",
year = "2013",
month = "4",
day = "1",
doi = "10.1016/j.numecd.2011.06.006",
language = "English",
volume = "23",
pages = "366--374",
journal = "Nutrition, Metabolism and Cardiovascular Diseases",
issn = "0939-4753",
publisher = "Elsevier",
number = "4",

}

Association of fatty acid composition in serum phospholipids with metabolic syndrome and arterial stiffness. / Kim, O. Y.; Lim, H. H.; Lee, M. J.; Kim, J. Y.; Lee, J. H.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 23, No. 4, 01.04.2013, p. 366-374.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of fatty acid composition in serum phospholipids with metabolic syndrome and arterial stiffness

AU - Kim, O. Y.

AU - Lim, H. H.

AU - Lee, M. J.

AU - Kim, J. Y.

AU - Lee, J. H.

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Background and aim: We examined the association of fatty acid (FA) composition in serum phospholipids with the features of metabolic syndrome (MetS) and arterial stiffness. Methods: Korean men (n= 593, 30-79yrs) were categorized based on the number of MetS risk factors (RFs) and measured for the markers of MetS, serum phospholipid FA composition and brachial-ankle pulse wave velocity (baPWV), an index for the severity of arterial stiffness. Results: Insulin resistance (HOMA-IR), baPWV, LDL size, and adiponectin were significantly altered corresponding to the number of MetS RFs. The proportions of total monounsaturated FA, palmitoleic acid (16:1), oleic acid (18:1ω-9) and dihomo-γ-linolenic acid (DGLA, 20:3ω-6) in serum phospholipids, and DGLA/linoleic acid (LA) (20:3ω-6/18:2ω-6), deta9-desaturase activity (D9D-16: 16:1/16:0 and D9D-18: 18:1ω-9/18:0) significantly increased corresponding to the number of MetS RFs, but D5D (20:4ω-6/20:3ω-6) decreased. baPWV positively correlated with HOMA-IR, palmitic acid (16:0), oleic acid, D6D (18:3ω-6/18:2ω-6), DGLA/LA and D9D-18, and negatively with adiponectin, LDL size, LA, docosahexaenoic acid (DHA, 22:6ω-3) and D5D. Multiple stepwise regression models revealed that baPWV was significantly influenced by systolic blood pressure, age, body weight, triglyceride and LA in serum phospholipids (R2=0.378). Interestingly, baPWV (1419±1cm/s) and MetS (22%) were highest in individuals with lower proportion of LA (<12.361%) and higher proportion of DGLA (≥1.412%) in serum phospholipid FAs. Conclusion: The features of MetS significantly related to serum phosopholipid FA composition. Particularly, arterial stiffness was associated with LA additively together with DLGA. It may suggest a potential benefit of sufficient amounts of LA in serum or in diet can reduce cardiovascular risk.

AB - Background and aim: We examined the association of fatty acid (FA) composition in serum phospholipids with the features of metabolic syndrome (MetS) and arterial stiffness. Methods: Korean men (n= 593, 30-79yrs) were categorized based on the number of MetS risk factors (RFs) and measured for the markers of MetS, serum phospholipid FA composition and brachial-ankle pulse wave velocity (baPWV), an index for the severity of arterial stiffness. Results: Insulin resistance (HOMA-IR), baPWV, LDL size, and adiponectin were significantly altered corresponding to the number of MetS RFs. The proportions of total monounsaturated FA, palmitoleic acid (16:1), oleic acid (18:1ω-9) and dihomo-γ-linolenic acid (DGLA, 20:3ω-6) in serum phospholipids, and DGLA/linoleic acid (LA) (20:3ω-6/18:2ω-6), deta9-desaturase activity (D9D-16: 16:1/16:0 and D9D-18: 18:1ω-9/18:0) significantly increased corresponding to the number of MetS RFs, but D5D (20:4ω-6/20:3ω-6) decreased. baPWV positively correlated with HOMA-IR, palmitic acid (16:0), oleic acid, D6D (18:3ω-6/18:2ω-6), DGLA/LA and D9D-18, and negatively with adiponectin, LDL size, LA, docosahexaenoic acid (DHA, 22:6ω-3) and D5D. Multiple stepwise regression models revealed that baPWV was significantly influenced by systolic blood pressure, age, body weight, triglyceride and LA in serum phospholipids (R2=0.378). Interestingly, baPWV (1419±1cm/s) and MetS (22%) were highest in individuals with lower proportion of LA (<12.361%) and higher proportion of DGLA (≥1.412%) in serum phospholipid FAs. Conclusion: The features of MetS significantly related to serum phosopholipid FA composition. Particularly, arterial stiffness was associated with LA additively together with DLGA. It may suggest a potential benefit of sufficient amounts of LA in serum or in diet can reduce cardiovascular risk.

UR - http://www.scopus.com/inward/record.url?scp=84875083387&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875083387&partnerID=8YFLogxK

U2 - 10.1016/j.numecd.2011.06.006

DO - 10.1016/j.numecd.2011.06.006

M3 - Article

C2 - 21920716

AN - SCOPUS:84875083387

VL - 23

SP - 366

EP - 374

JO - Nutrition, Metabolism and Cardiovascular Diseases

JF - Nutrition, Metabolism and Cardiovascular Diseases

SN - 0939-4753

IS - 4

ER -