Association of G-33A polymorphism in the thrombomodulin gene with myocardial infarction in Koreans

Hyun Young Park, Toru Nabika, Yangsoo Jang, Hyuck Moon Kwon, Seung Yun Cho, Junichi Masuda

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Thrombomodulin (TM), a thrombin receptor expressed on the endothelial surface, is known to play an important role in the anti-thrombogenic system in vivo. In this study, we examined the effects of 3 single-nucleotide polymorphisms (SNPs) in the TM gene (G-33A, C1418T and C1922T) on the development of myocardial infarction (MI) in Koreans. We found that G-33A was a common SNP (the minor allele frequency was 0.09) in Koreans. Eighty-five MI patients who had received coronary angiography were enrolled and were divided into 3 groups according to the number of coronary arteries in which stenosis was found angiographically (1-vessel disease (1VD) to 3-vessel disease (3VD)). The criterion of coronary stenosis was 50% or more stenosis on angiography. In addition, 102 controls (CONT) who had no significant stenosis were employed. The number of AA/GA genotypes of G-33A was found to be significantly greater in the 1VD than in the CONT (p=0.004 by X2-test) while no significant difference was found between the multivessel disease (2-3VD) and the CONT. Multiple logistic analysis showed that G-33A was an independent risk factor for the 1VD with an odds ratio of 4.63 (95% confidence interval; 1.62-13.3). C1418T and C1922T were both in linkage disequilibrium with G-33A; however, they were not independent risks for either the 1VD or the 2-3VD. A reporter gene assay showed that G-33A had a significant effect on the TM promoter activity. These results indicated that G-33A polymorphism in TM might be a genetic risk factor for myocardial infarction.

Original languageEnglish
Pages (from-to)389-394
Number of pages6
JournalHypertension Research
Volume25
Issue number3
DOIs
Publication statusPublished - 2002 Jan 1

Fingerprint

Thrombomodulin
Myocardial Infarction
Genes
Pathologic Constriction
Single Nucleotide Polymorphism
Thrombin Receptors
Coronary Stenosis
Linkage Disequilibrium
Coronary Angiography
Reporter Genes
Gene Frequency
Coronary Vessels
Angiography
Odds Ratio
Genotype
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Park, Hyun Young ; Nabika, Toru ; Jang, Yangsoo ; Kwon, Hyuck Moon ; Cho, Seung Yun ; Masuda, Junichi. / Association of G-33A polymorphism in the thrombomodulin gene with myocardial infarction in Koreans. In: Hypertension Research. 2002 ; Vol. 25, No. 3. pp. 389-394.
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Association of G-33A polymorphism in the thrombomodulin gene with myocardial infarction in Koreans. / Park, Hyun Young; Nabika, Toru; Jang, Yangsoo; Kwon, Hyuck Moon; Cho, Seung Yun; Masuda, Junichi.

In: Hypertension Research, Vol. 25, No. 3, 01.01.2002, p. 389-394.

Research output: Contribution to journalArticle

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