Association of genetic variations in CCR5 and its ligand, RANTES with clearance of hepatitis B virus in Korea

Sang Hoon Ahn, Do Young Kim, Hye Young Chang, Sun Pyo Hong, Jeon Soo Shin, Yu Seun Kim, Hyejin Kim, Ja Kyung Kim, Yong Han Paik, Kwan Sik Lee, Chae Yoon Chon, Young Myoung Moon, Kwang Hyub Han

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Abstract

Immunogenetic factors may play a role in determining the susceptibility of an individual to viral infection. The aim of current study was to investigate the association of clearance of hepatitis B virus (HBV) with promoter polymorphisms within the CC chemokine receptor 5 (CCR5) and its major ligand, regulated upon activation, normal T cells expressed and secreted (RANTES) genes. Five chemokine system polymorphisms (CCR5 Δ32, CCR5 promoter 59029G/A, 59353C/T, RANTES -403G/A, and -28C/G) were studied in a total of 698 subjects. The carriage of each genetic variant was compared among "spontaneously recovered" group (n = 243), "chronic carrier" group (n = 349), and "unexposed" group (n = 106). CCR5 59029G promoter variant was associated with clearance of HBV infection in an acute phase (OR = 1.71, P = 0.006, dominant model; OR = 2.17, P< 0.001, recessive model) and amelioration of hepatic inflammation (P = 0.003) with the control of HBV replication (P = 0.04) in chronic carriers. Interestingly, CCR5 59029 was linked completely to CCR5 59353, and CCR5 Δ32 homozygosity or heterozygosity was not found in any Korean patient. No association was seen with RANTES polymorphisms at position -403 and -28. The CCR5 59029G/CCR5 59353T polymorphism may play a role in the clearance of HBV infection.

Original languageEnglish
Pages (from-to)1564-1571
Number of pages8
JournalJournal of Medical Virology
Volume78
Issue number12
DOIs
Publication statusPublished - 2006 Dec 1

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CCR5 Receptors
Korea
Hepatitis B virus
Ligands
T-Lymphocytes
Virus Diseases
Immunogenetics
Virus Replication
Chemokines
Inflammation

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

Cite this

Ahn, Sang Hoon ; Kim, Do Young ; Chang, Hye Young ; Hong, Sun Pyo ; Shin, Jeon Soo ; Kim, Yu Seun ; Kim, Hyejin ; Kim, Ja Kyung ; Paik, Yong Han ; Lee, Kwan Sik ; Chon, Chae Yoon ; Moon, Young Myoung ; Han, Kwang Hyub. / Association of genetic variations in CCR5 and its ligand, RANTES with clearance of hepatitis B virus in Korea. In: Journal of Medical Virology. 2006 ; Vol. 78, No. 12. pp. 1564-1571.
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Association of genetic variations in CCR5 and its ligand, RANTES with clearance of hepatitis B virus in Korea. / Ahn, Sang Hoon; Kim, Do Young; Chang, Hye Young; Hong, Sun Pyo; Shin, Jeon Soo; Kim, Yu Seun; Kim, Hyejin; Kim, Ja Kyung; Paik, Yong Han; Lee, Kwan Sik; Chon, Chae Yoon; Moon, Young Myoung; Han, Kwang Hyub.

In: Journal of Medical Virology, Vol. 78, No. 12, 01.12.2006, p. 1564-1571.

Research output: Contribution to journalArticle

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T1 - Association of genetic variations in CCR5 and its ligand, RANTES with clearance of hepatitis B virus in Korea

AU - Ahn, Sang Hoon

AU - Kim, Do Young

AU - Chang, Hye Young

AU - Hong, Sun Pyo

AU - Shin, Jeon Soo

AU - Kim, Yu Seun

AU - Kim, Hyejin

AU - Kim, Ja Kyung

AU - Paik, Yong Han

AU - Lee, Kwan Sik

AU - Chon, Chae Yoon

AU - Moon, Young Myoung

AU - Han, Kwang Hyub

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N2 - Immunogenetic factors may play a role in determining the susceptibility of an individual to viral infection. The aim of current study was to investigate the association of clearance of hepatitis B virus (HBV) with promoter polymorphisms within the CC chemokine receptor 5 (CCR5) and its major ligand, regulated upon activation, normal T cells expressed and secreted (RANTES) genes. Five chemokine system polymorphisms (CCR5 Δ32, CCR5 promoter 59029G/A, 59353C/T, RANTES -403G/A, and -28C/G) were studied in a total of 698 subjects. The carriage of each genetic variant was compared among "spontaneously recovered" group (n = 243), "chronic carrier" group (n = 349), and "unexposed" group (n = 106). CCR5 59029G promoter variant was associated with clearance of HBV infection in an acute phase (OR = 1.71, P = 0.006, dominant model; OR = 2.17, P< 0.001, recessive model) and amelioration of hepatic inflammation (P = 0.003) with the control of HBV replication (P = 0.04) in chronic carriers. Interestingly, CCR5 59029 was linked completely to CCR5 59353, and CCR5 Δ32 homozygosity or heterozygosity was not found in any Korean patient. No association was seen with RANTES polymorphisms at position -403 and -28. The CCR5 59029G/CCR5 59353T polymorphism may play a role in the clearance of HBV infection.

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