TY - JOUR
T1 - Association of high metabolic activity measured by positron emission tomography imaging with poor prognosis of choroidal melanoma
AU - Lee, Christopher Seungkyu
AU - Cho, Arthur
AU - Lee, Kyu Sung
AU - Lee, Sung Chul
PY - 2011/11
Y1 - 2011/11
N2 - Aims: To evaluate the prognostic value of positron emission tomography (PET) imaging in patients with choroidal melanoma. Methods: We undertook a retrospective review of 40 consecutive patients with choroidal melanoma who underwent pretreatment whole-body PET, received either brachytherapy using ruthenium-106 plaque, enucleation or gamma knife radiotherapy, and had 1 year of follow-up. Metabolic activity of choroidal melanoma measured as standardised uptake value (SUV) by PET imaging was evaluated with respect to the survival of patients. Results: SUV (p=0.003) and the largest basal diameter of the tumour (p=0.003) were significantly correlated with metastatic death (Cox proportional hazards regression). There was an inverse correlation between tumour metabolic activity and time to metastasis (p=0.049; linear regression). Conclusion: Metabolic activity by PET imaging significantly predicted the survival of patients with choroidal melanoma.
AB - Aims: To evaluate the prognostic value of positron emission tomography (PET) imaging in patients with choroidal melanoma. Methods: We undertook a retrospective review of 40 consecutive patients with choroidal melanoma who underwent pretreatment whole-body PET, received either brachytherapy using ruthenium-106 plaque, enucleation or gamma knife radiotherapy, and had 1 year of follow-up. Metabolic activity of choroidal melanoma measured as standardised uptake value (SUV) by PET imaging was evaluated with respect to the survival of patients. Results: SUV (p=0.003) and the largest basal diameter of the tumour (p=0.003) were significantly correlated with metastatic death (Cox proportional hazards regression). There was an inverse correlation between tumour metabolic activity and time to metastasis (p=0.049; linear regression). Conclusion: Metabolic activity by PET imaging significantly predicted the survival of patients with choroidal melanoma.
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U2 - 10.1136/bjo.2010.198085
DO - 10.1136/bjo.2010.198085
M3 - Article
C2 - 21317424
AN - SCOPUS:80054950668
VL - 95
SP - 1588
EP - 1591
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
SN - 0007-1161
IS - 11
ER -