Association of high metabolic activity measured by positron emission tomography imaging with poor prognosis of choroidal melanoma

Christopher Seungkyu Lee, Arthur Cho, Kyu Sung Lee, Sungchul Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aims: To evaluate the prognostic value of positron emission tomography (PET) imaging in patients with choroidal melanoma. Methods: We undertook a retrospective review of 40 consecutive patients with choroidal melanoma who underwent pretreatment whole-body PET, received either brachytherapy using ruthenium-106 plaque, enucleation or gamma knife radiotherapy, and had 1 year of follow-up. Metabolic activity of choroidal melanoma measured as standardised uptake value (SUV) by PET imaging was evaluated with respect to the survival of patients. Results: SUV (p=0.003) and the largest basal diameter of the tumour (p=0.003) were significantly correlated with metastatic death (Cox proportional hazards regression). There was an inverse correlation between tumour metabolic activity and time to metastasis (p=0.049; linear regression). Conclusion: Metabolic activity by PET imaging significantly predicted the survival of patients with choroidal melanoma.

Original languageEnglish
Pages (from-to)1588-1591
Number of pages4
JournalBritish Journal of Ophthalmology
Volume95
Issue number11
DOIs
Publication statusPublished - 2011 Nov 1

Fingerprint

Positron-Emission Tomography
Melanoma
Ruthenium
Survival
Brachytherapy
Linear Models
Neoplasms
Radiotherapy
Neoplasm Metastasis

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

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abstract = "Aims: To evaluate the prognostic value of positron emission tomography (PET) imaging in patients with choroidal melanoma. Methods: We undertook a retrospective review of 40 consecutive patients with choroidal melanoma who underwent pretreatment whole-body PET, received either brachytherapy using ruthenium-106 plaque, enucleation or gamma knife radiotherapy, and had 1 year of follow-up. Metabolic activity of choroidal melanoma measured as standardised uptake value (SUV) by PET imaging was evaluated with respect to the survival of patients. Results: SUV (p=0.003) and the largest basal diameter of the tumour (p=0.003) were significantly correlated with metastatic death (Cox proportional hazards regression). There was an inverse correlation between tumour metabolic activity and time to metastasis (p=0.049; linear regression). Conclusion: Metabolic activity by PET imaging significantly predicted the survival of patients with choroidal melanoma.",
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Association of high metabolic activity measured by positron emission tomography imaging with poor prognosis of choroidal melanoma. / Lee, Christopher Seungkyu; Cho, Arthur; Lee, Kyu Sung; Lee, Sungchul.

In: British Journal of Ophthalmology, Vol. 95, No. 11, 01.11.2011, p. 1588-1591.

Research output: Contribution to journalArticle

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AB - Aims: To evaluate the prognostic value of positron emission tomography (PET) imaging in patients with choroidal melanoma. Methods: We undertook a retrospective review of 40 consecutive patients with choroidal melanoma who underwent pretreatment whole-body PET, received either brachytherapy using ruthenium-106 plaque, enucleation or gamma knife radiotherapy, and had 1 year of follow-up. Metabolic activity of choroidal melanoma measured as standardised uptake value (SUV) by PET imaging was evaluated with respect to the survival of patients. Results: SUV (p=0.003) and the largest basal diameter of the tumour (p=0.003) were significantly correlated with metastatic death (Cox proportional hazards regression). There was an inverse correlation between tumour metabolic activity and time to metastasis (p=0.049; linear regression). Conclusion: Metabolic activity by PET imaging significantly predicted the survival of patients with choroidal melanoma.

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