Association of high metabolic activity measured by positron emission tomography imaging with poor prognosis of choroidal melanoma

Christopher Seungkyu Lee, Arthur Cho, Kyu Sung Lee, Sung Chul Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Aims: To evaluate the prognostic value of positron emission tomography (PET) imaging in patients with choroidal melanoma. Methods: We undertook a retrospective review of 40 consecutive patients with choroidal melanoma who underwent pretreatment whole-body PET, received either brachytherapy using ruthenium-106 plaque, enucleation or gamma knife radiotherapy, and had 1 year of follow-up. Metabolic activity of choroidal melanoma measured as standardised uptake value (SUV) by PET imaging was evaluated with respect to the survival of patients. Results: SUV (p=0.003) and the largest basal diameter of the tumour (p=0.003) were significantly correlated with metastatic death (Cox proportional hazards regression). There was an inverse correlation between tumour metabolic activity and time to metastasis (p=0.049; linear regression). Conclusion: Metabolic activity by PET imaging significantly predicted the survival of patients with choroidal melanoma.

Original languageEnglish
Pages (from-to)1588-1591
Number of pages4
JournalBritish Journal of Ophthalmology
Volume95
Issue number11
DOIs
Publication statusPublished - 2011 Nov 1

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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