Association of human antigen class i genes with cold medicine-related Stevens-Johnson syndrome with severe ocular complications in a Korean population

Ikhyun Jun, John Hoon Rim, Mee Kum Kim, Kyung Chul Yoon, Choun Ki Joo, Shigeru Kinoshita, Kyoung Yul Seo, Mayumi Ueta

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15 Citations (Scopus)


Background/aims Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are a spectrum of diseases that cause an acute vesiculobullous reaction in the skin and mucous membranes. The occurrence of these diseases is associated with various drugs, a large proportion of which is comprised cold medicines (CM). We try to investigate the association between human leucocyte antigen (HLA) class I genes and CM-related SJS/TEN (CM-SJS/TEN) with severe ocular complications (SOC) in the Korean population. Methods This multicentre case-control study enrolled 40 Korean patients with CM-SJS/TEN with SOC and 120 age-matched and sex-matched Korean healthy volunteers between January 2012 and May 2014. HLA genotyping was performed using PCR followed by hybridisation with sequence-specific oligonucleotide probes. Results The carrier frequency and gene frequency of HLA-A∗02:06 were 37.5 % and 20.0 %, respectively, in patients, and 16.7 % and 9.6 %, respectively, in controls (p=0.018). The carrier frequency of HLA-C∗03:04 was 30 % in patients and 10.8 % in controls, and gene frequency of HLA-C∗03:04 was 15 % in patients and 5.4 % in controls (p=0.003). The carrier frequency and gene frequency of HLA-C∗03:03 were 2.5 % and 1.3 %, respectively, in patients, and 20 % and 10.4 %, respectively, in controls (p=0.006). Conclusions As per our results, we suggest that HLA-A∗02:06 and HLA-C∗03:04 might be positive markers for CM-SJS/TEN with SOC, and HLA-C∗03:03 might be an indicator of protection against CM-SJS/TEN with SOC in the Korean population.

Original languageEnglish
Pages (from-to)573-576
Number of pages4
JournalBritish Journal of Ophthalmology
Issue number4
Publication statusPublished - 2019 Apr 1

Bibliographical note

Funding Information:
Funding This work was supported partly by grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of the Japanese government and the JSPS Core-to-Core Program, A. Advanced Research Networks (MU) and grants NRF-2013M3A9D5072551 (KYS) from the Bio & Medical Technology Development Program of the National Research Foundation funded by the Ministry of Science, ICT and Future Planning.

Publisher Copyright:
© Author(s) (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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