Association of Intraluminal Thrombus, Hemodynamic Forces, and Abdominal Aortic Aneurysm Expansion Using Longitudinal CT Images

Byron A. Zambrano, Hamidreza Gharahi, Chae Young Lim, Farhad A. Jaberi, Jongeun Choi, Whal Lee, Seungik Baek

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

While hemodynamic forces and intraluminal thrombus (ILT) are believed to play important roles on abdominal aortic aneurysm (AAA), it has been suggested that hemodynamic forces and ILT also interact with each other, making it a complex problem. There is, however, a pressing need to understand relationships among three factors: hemodynamics, ILT accumulation, and AAA expansion for AAA prognosis. Hence this study used longitudinal computer tomography scans from 14 patients and analyzed the relationship between them. Hemodynamic forces, represented by wall shear stress (WSS), were obtained from computational fluid dynamics; ILT accumulation was described by ILT thickness distribution changes between consecutives scans, and ILT accumulation and AAA expansion rates were estimated from changes in ILT and AAA volume. Results showed that, while low WSS was observed at regions where ILT accumulated, the rate at which ILT accumulated occurred at the same rate as the aneurysm expansion. Comparison between AAAs with and without thrombus showed that aneurysm with ILT recorded lower values of WSS and higher values of AAA expansion than those without thrombus. Findings suggest that low WSS may promote ILT accumulation and submit the idea that by increasing WSS levels ILT accumulation may be prevented.

Original languageEnglish
Pages (from-to)1502-1514
Number of pages13
JournalAnnals of Biomedical Engineering
Volume44
Issue number5
DOIs
Publication statusPublished - 2016 May 1

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Hemodynamics
Shear stress
Tomography
Computational fluid dynamics

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Cite this

Zambrano, Byron A. ; Gharahi, Hamidreza ; Lim, Chae Young ; Jaberi, Farhad A. ; Choi, Jongeun ; Lee, Whal ; Baek, Seungik. / Association of Intraluminal Thrombus, Hemodynamic Forces, and Abdominal Aortic Aneurysm Expansion Using Longitudinal CT Images. In: Annals of Biomedical Engineering. 2016 ; Vol. 44, No. 5. pp. 1502-1514.
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Association of Intraluminal Thrombus, Hemodynamic Forces, and Abdominal Aortic Aneurysm Expansion Using Longitudinal CT Images. / Zambrano, Byron A.; Gharahi, Hamidreza; Lim, Chae Young; Jaberi, Farhad A.; Choi, Jongeun; Lee, Whal; Baek, Seungik.

In: Annals of Biomedical Engineering, Vol. 44, No. 5, 01.05.2016, p. 1502-1514.

Research output: Contribution to journalArticle

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