Abstract
Objective The aim of this study was to evaluate the association between prenatally diagnosed isolated single umbilical artery (iSUA) and perinatal outcomes. Methods We searched Medline, Embase, the Cochrane Library, and KoreaMed from inception to January 2016, with no language or regional restrictions, for cohort and case-control studies reporting on the relationship of iSUA and perinatal outcomes. We assessed the odds ratios (ORs) and 95% confidence intervals (CIs) for the occurrence of small for gestational age, preterm birth, pregnancy-induced hypertension, neonatal intensive care unit admission, and perinatal mortality in fetuses with iSUA compared with those in fetuses with three vessel cord. Results Eleven articles totaling 1,731 pregnancies with iSUA met the selection criteria. Studies varied in design, quality, outcome definition, and results. Meta-analysis carried out within predefined groups showed that the presence of an iSUA was associated with small for gestational age (OR, 2.75; 95% CI, 1.97 to 3.83; P < 0.00001), preterm birth (OR, 2.10; 95% CI, 1.72 to 2.57; P < 0.00001), pregnancy-induced hypertension (OR, 1.62; 95% CI, 1.00 to 2.63; P=0.05), neonatal intensive care unit admission (OR, 2.06; 95% CI, 1.33 to 3.19; P = 0.001), and perinatal mortality (OR, 2.29; 95% CI, 1.32 to 3.98; P=0.003). Conclusion Pregnancies complicated by iSUA are at increased risk for small for gestational age, preterm birth, pregnancy-induced hypertension, neonatal intensive care unit admission and perinatal mortality. Further, large prospective cohort studies are required to improve the quality of prenatal counseling and the neonatal care for pregnancies with iSUA.
| Original language | English |
|---|---|
| Pages (from-to) | 266-273 |
| Number of pages | 8 |
| Journal | Obstetrics and Gynecology Science |
| Volume | 60 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2017 May 1 |
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All Science Journal Classification (ASJC) codes
- Obstetrics and Gynaecology
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Association of isolated single umbilical artery with perinatal outcomes : Systemic review and meta-analysis. / Kim, Hyeong Ju; Kim, Jae-Hoon; Chay, Doo Byung; Park, Joo Hyun; Kim, Min A.
In: Obstetrics and Gynecology Science, Vol. 60, No. 3, 01.05.2017, p. 266-273.Research output: Contribution to journal › Article
TY - JOUR
T1 - Association of isolated single umbilical artery with perinatal outcomes
T2 - Systemic review and meta-analysis
AU - Kim, Hyeong Ju
AU - Kim, Jae-Hoon
AU - Chay, Doo Byung
AU - Park, Joo Hyun
AU - Kim, Min A.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - Objective The aim of this study was to evaluate the association between prenatally diagnosed isolated single umbilical artery (iSUA) and perinatal outcomes. Methods We searched Medline, Embase, the Cochrane Library, and KoreaMed from inception to January 2016, with no language or regional restrictions, for cohort and case-control studies reporting on the relationship of iSUA and perinatal outcomes. We assessed the odds ratios (ORs) and 95% confidence intervals (CIs) for the occurrence of small for gestational age, preterm birth, pregnancy-induced hypertension, neonatal intensive care unit admission, and perinatal mortality in fetuses with iSUA compared with those in fetuses with three vessel cord. Results Eleven articles totaling 1,731 pregnancies with iSUA met the selection criteria. Studies varied in design, quality, outcome definition, and results. Meta-analysis carried out within predefined groups showed that the presence of an iSUA was associated with small for gestational age (OR, 2.75; 95% CI, 1.97 to 3.83; P < 0.00001), preterm birth (OR, 2.10; 95% CI, 1.72 to 2.57; P < 0.00001), pregnancy-induced hypertension (OR, 1.62; 95% CI, 1.00 to 2.63; P=0.05), neonatal intensive care unit admission (OR, 2.06; 95% CI, 1.33 to 3.19; P = 0.001), and perinatal mortality (OR, 2.29; 95% CI, 1.32 to 3.98; P=0.003). Conclusion Pregnancies complicated by iSUA are at increased risk for small for gestational age, preterm birth, pregnancy-induced hypertension, neonatal intensive care unit admission and perinatal mortality. Further, large prospective cohort studies are required to improve the quality of prenatal counseling and the neonatal care for pregnancies with iSUA.
AB - Objective The aim of this study was to evaluate the association between prenatally diagnosed isolated single umbilical artery (iSUA) and perinatal outcomes. Methods We searched Medline, Embase, the Cochrane Library, and KoreaMed from inception to January 2016, with no language or regional restrictions, for cohort and case-control studies reporting on the relationship of iSUA and perinatal outcomes. We assessed the odds ratios (ORs) and 95% confidence intervals (CIs) for the occurrence of small for gestational age, preterm birth, pregnancy-induced hypertension, neonatal intensive care unit admission, and perinatal mortality in fetuses with iSUA compared with those in fetuses with three vessel cord. Results Eleven articles totaling 1,731 pregnancies with iSUA met the selection criteria. Studies varied in design, quality, outcome definition, and results. Meta-analysis carried out within predefined groups showed that the presence of an iSUA was associated with small for gestational age (OR, 2.75; 95% CI, 1.97 to 3.83; P < 0.00001), preterm birth (OR, 2.10; 95% CI, 1.72 to 2.57; P < 0.00001), pregnancy-induced hypertension (OR, 1.62; 95% CI, 1.00 to 2.63; P=0.05), neonatal intensive care unit admission (OR, 2.06; 95% CI, 1.33 to 3.19; P = 0.001), and perinatal mortality (OR, 2.29; 95% CI, 1.32 to 3.98; P=0.003). Conclusion Pregnancies complicated by iSUA are at increased risk for small for gestational age, preterm birth, pregnancy-induced hypertension, neonatal intensive care unit admission and perinatal mortality. Further, large prospective cohort studies are required to improve the quality of prenatal counseling and the neonatal care for pregnancies with iSUA.
UR - http://www.scopus.com/inward/record.url?scp=85028363798&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85028363798&partnerID=8YFLogxK
U2 - 10.5468/ogs.2017.60.3.266
DO - 10.5468/ogs.2017.60.3.266
M3 - Article
AN - SCOPUS:85028363798
VL - 60
SP - 266
EP - 273
JO - Obstetrics and Gynecology Science
JF - Obstetrics and Gynecology Science
SN - 2287-8572
IS - 3
ER -