Association of Lp-PLA 2 activity and LDL size with interleukin-6, an inflammatory cytokine and oxidized LDL, a marker of oxidative stress, in women with metabolic syndrome

Jey Sook Chae, Oh Yoen Kim, Jean Kyung Paik, Ryungwoo Kang, Woo Ju Seo, Tae Sook Jeong, Gary Sweeney, Sang Hyun Lee, Jong Ho Lee

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objective: We investigated an association between lipoprotein-associated phospholipase A 2 (Lp-PLA 2) activity, inflammation, and oxidative stress in women with metabolic syndrome (MS). Methods: We performed a case-control study in MS women (n=368) and non-MS women (n=854). Lp-PLA 2 activity LDL particle size; leukocyte number; ox-LDL, LDL-cholesterol, TNF-α, IL-6, and CRP levels were measured. Results: MS women had smaller LDL particle size; higher plasma ox-LDL levels and Lp-PLA 2 activity; and higher serum TNF-α, IL-6, and CRP, than non-MS women. In controls, Lp-PLA 2 activity weakly but significantly correlated with LDL-cholesterol; in MS women, Lp-PLA 2 activity positively correlated with LDL-cholesterol, ox-LDL, TNF-α, and IL-6 after adjusting for age and BMI. The relationship between Lp-PLA 2 activity and ox-LDL still maintained after further adjustment for LDL-cholesterol. Additionally, Lp-PLA 2 activity together with LDL particle size were significant independent predictors of MS (multivariate analysis), and ox-LDL was a major contributor to the increase in Lp-PLA 2 activity in MS women (multiple stepwise regression). In a subgroup analysis, Lp-PLA 2 activity was negatively associated with IL-6 levels in non-MS postmenopausal women, but positively with IL-6 in both postmenopausal and premenopausal women with MS. Postmenopausal women with MS had significantly higher Lp-PLA 2 activity, ox-LDL and IL-6 than those without MS, and premenopausal women with or without MS, after the adjustment. Conclusions: Elevated plasma Lp-PLA 2 activity was associated with an increase in inflammatory cytokines, particularly IL-6 and ox-LDL in MS women. This association was also affected by menopause status, suggesting that Lp-PLA 2 may represent a novel marker for oxidation and inflammation in MS.

Original languageEnglish
Pages (from-to)499-506
Number of pages8
JournalAtherosclerosis
Volume218
Issue number2
DOIs
Publication statusPublished - 2011 Oct 1

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1-Alkyl-2-acetylglycerophosphocholine Esterase
Interleukin-6
Oxidative Stress
Cytokines
LDL Cholesterol
Particle Size
oxidized low density lipoprotein
Inflammation

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Chae, Jey Sook ; Kim, Oh Yoen ; Paik, Jean Kyung ; Kang, Ryungwoo ; Seo, Woo Ju ; Jeong, Tae Sook ; Sweeney, Gary ; Lee, Sang Hyun ; Lee, Jong Ho. / Association of Lp-PLA 2 activity and LDL size with interleukin-6, an inflammatory cytokine and oxidized LDL, a marker of oxidative stress, in women with metabolic syndrome. In: Atherosclerosis. 2011 ; Vol. 218, No. 2. pp. 499-506.
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abstract = "Objective: We investigated an association between lipoprotein-associated phospholipase A 2 (Lp-PLA 2) activity, inflammation, and oxidative stress in women with metabolic syndrome (MS). Methods: We performed a case-control study in MS women (n=368) and non-MS women (n=854). Lp-PLA 2 activity LDL particle size; leukocyte number; ox-LDL, LDL-cholesterol, TNF-α, IL-6, and CRP levels were measured. Results: MS women had smaller LDL particle size; higher plasma ox-LDL levels and Lp-PLA 2 activity; and higher serum TNF-α, IL-6, and CRP, than non-MS women. In controls, Lp-PLA 2 activity weakly but significantly correlated with LDL-cholesterol; in MS women, Lp-PLA 2 activity positively correlated with LDL-cholesterol, ox-LDL, TNF-α, and IL-6 after adjusting for age and BMI. The relationship between Lp-PLA 2 activity and ox-LDL still maintained after further adjustment for LDL-cholesterol. Additionally, Lp-PLA 2 activity together with LDL particle size were significant independent predictors of MS (multivariate analysis), and ox-LDL was a major contributor to the increase in Lp-PLA 2 activity in MS women (multiple stepwise regression). In a subgroup analysis, Lp-PLA 2 activity was negatively associated with IL-6 levels in non-MS postmenopausal women, but positively with IL-6 in both postmenopausal and premenopausal women with MS. Postmenopausal women with MS had significantly higher Lp-PLA 2 activity, ox-LDL and IL-6 than those without MS, and premenopausal women with or without MS, after the adjustment. Conclusions: Elevated plasma Lp-PLA 2 activity was associated with an increase in inflammatory cytokines, particularly IL-6 and ox-LDL in MS women. This association was also affected by menopause status, suggesting that Lp-PLA 2 may represent a novel marker for oxidation and inflammation in MS.",
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Association of Lp-PLA 2 activity and LDL size with interleukin-6, an inflammatory cytokine and oxidized LDL, a marker of oxidative stress, in women with metabolic syndrome. / Chae, Jey Sook; Kim, Oh Yoen; Paik, Jean Kyung; Kang, Ryungwoo; Seo, Woo Ju; Jeong, Tae Sook; Sweeney, Gary; Lee, Sang Hyun; Lee, Jong Ho.

In: Atherosclerosis, Vol. 218, No. 2, 01.10.2011, p. 499-506.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of Lp-PLA 2 activity and LDL size with interleukin-6, an inflammatory cytokine and oxidized LDL, a marker of oxidative stress, in women with metabolic syndrome

AU - Chae, Jey Sook

AU - Kim, Oh Yoen

AU - Paik, Jean Kyung

AU - Kang, Ryungwoo

AU - Seo, Woo Ju

AU - Jeong, Tae Sook

AU - Sweeney, Gary

AU - Lee, Sang Hyun

AU - Lee, Jong Ho

PY - 2011/10/1

Y1 - 2011/10/1

N2 - Objective: We investigated an association between lipoprotein-associated phospholipase A 2 (Lp-PLA 2) activity, inflammation, and oxidative stress in women with metabolic syndrome (MS). Methods: We performed a case-control study in MS women (n=368) and non-MS women (n=854). Lp-PLA 2 activity LDL particle size; leukocyte number; ox-LDL, LDL-cholesterol, TNF-α, IL-6, and CRP levels were measured. Results: MS women had smaller LDL particle size; higher plasma ox-LDL levels and Lp-PLA 2 activity; and higher serum TNF-α, IL-6, and CRP, than non-MS women. In controls, Lp-PLA 2 activity weakly but significantly correlated with LDL-cholesterol; in MS women, Lp-PLA 2 activity positively correlated with LDL-cholesterol, ox-LDL, TNF-α, and IL-6 after adjusting for age and BMI. The relationship between Lp-PLA 2 activity and ox-LDL still maintained after further adjustment for LDL-cholesterol. Additionally, Lp-PLA 2 activity together with LDL particle size were significant independent predictors of MS (multivariate analysis), and ox-LDL was a major contributor to the increase in Lp-PLA 2 activity in MS women (multiple stepwise regression). In a subgroup analysis, Lp-PLA 2 activity was negatively associated with IL-6 levels in non-MS postmenopausal women, but positively with IL-6 in both postmenopausal and premenopausal women with MS. Postmenopausal women with MS had significantly higher Lp-PLA 2 activity, ox-LDL and IL-6 than those without MS, and premenopausal women with or without MS, after the adjustment. Conclusions: Elevated plasma Lp-PLA 2 activity was associated with an increase in inflammatory cytokines, particularly IL-6 and ox-LDL in MS women. This association was also affected by menopause status, suggesting that Lp-PLA 2 may represent a novel marker for oxidation and inflammation in MS.

AB - Objective: We investigated an association between lipoprotein-associated phospholipase A 2 (Lp-PLA 2) activity, inflammation, and oxidative stress in women with metabolic syndrome (MS). Methods: We performed a case-control study in MS women (n=368) and non-MS women (n=854). Lp-PLA 2 activity LDL particle size; leukocyte number; ox-LDL, LDL-cholesterol, TNF-α, IL-6, and CRP levels were measured. Results: MS women had smaller LDL particle size; higher plasma ox-LDL levels and Lp-PLA 2 activity; and higher serum TNF-α, IL-6, and CRP, than non-MS women. In controls, Lp-PLA 2 activity weakly but significantly correlated with LDL-cholesterol; in MS women, Lp-PLA 2 activity positively correlated with LDL-cholesterol, ox-LDL, TNF-α, and IL-6 after adjusting for age and BMI. The relationship between Lp-PLA 2 activity and ox-LDL still maintained after further adjustment for LDL-cholesterol. Additionally, Lp-PLA 2 activity together with LDL particle size were significant independent predictors of MS (multivariate analysis), and ox-LDL was a major contributor to the increase in Lp-PLA 2 activity in MS women (multiple stepwise regression). In a subgroup analysis, Lp-PLA 2 activity was negatively associated with IL-6 levels in non-MS postmenopausal women, but positively with IL-6 in both postmenopausal and premenopausal women with MS. Postmenopausal women with MS had significantly higher Lp-PLA 2 activity, ox-LDL and IL-6 than those without MS, and premenopausal women with or without MS, after the adjustment. Conclusions: Elevated plasma Lp-PLA 2 activity was associated with an increase in inflammatory cytokines, particularly IL-6 and ox-LDL in MS women. This association was also affected by menopause status, suggesting that Lp-PLA 2 may represent a novel marker for oxidation and inflammation in MS.

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