Association of metabolic syndrome and 25-hydroxyvitamin D with cognitive impairment among elderly Koreans

Eun Young Lee, Su Jin Lee, Kyoung Min Kim, Young Mi Yun, Bo Mi Song, Jong Eun Kim, Hyeon Chang Kim, Yumie Rhee, Yoosik Youm, Chang Oh Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Aim: Metabolic syndrome and vitamin D deficiency are prevalent in older adults, and are considered risk factors for cognitive impairment. We investigated the combined effects of MetS and serum 25-hydroxyvitamin D (25[OH]D) levels on cognitive function in older adults. Methods: We studied 2940 participants aged ≥65 years from the Korean Urban Rural Elderly cohort study. Metabolic syndrome was defined according to the updated Adult Treatment Panel III criteria. Serum 25(OH)D levels were categorized into four groups: <25, 25–49, 50–74 and ≥75 nmol/L. Cognitive function was assessed using the Mini-Mental State Examination. Results: Participants with cognitive impairment had higher metabolic syndrome prevalence and lower serum 25(OH)D levels than those without cognitive impairment. In univariate analysis, both metabolic syndrome and low 25(OH)D levels were associated with cognitive impairment. These associations remained unchanged after adjusting for potential confounders including age, sex, season and education. In addition, participants with metabolic syndrome and low 25(OH)D had significantly increased odds for cognitive impairment (odds ratio 3.06, 95% CI 1.61–5.80) when compared with those with no metabolic syndrome and high 25(OH)D. Conclusions: Metabolic syndrome was associated with cognitive impairment, and this risk was synergistically increased when metabolic syndrome was combined with low 25(OH)D. A focus on individuals with metabolic syndrome and low 25(OH)D might be helpful to identify older adults who are at risk of cognitive impairment. Geriatr Gerontol Int 2017; 17: 1069–1075.

Original languageEnglish
Pages (from-to)1069-1075
Number of pages7
JournalGeriatrics and Gerontology International
Volume17
Issue number7
DOIs
Publication statusPublished - 2017 Jul

Fingerprint

Cognition
Serum
examination
25-hydroxyvitamin D
Cognitive Dysfunction
Vitamin D Deficiency
Sex Education
education
Group
Cohort Studies
Odds Ratio
Therapeutics

All Science Journal Classification (ASJC) codes

  • Health(social science)
  • Gerontology
  • Geriatrics and Gerontology

Cite this

Lee, Eun Young ; Lee, Su Jin ; Kim, Kyoung Min ; Yun, Young Mi ; Song, Bo Mi ; Kim, Jong Eun ; Kim, Hyeon Chang ; Rhee, Yumie ; Youm, Yoosik ; Kim, Chang Oh. / Association of metabolic syndrome and 25-hydroxyvitamin D with cognitive impairment among elderly Koreans. In: Geriatrics and Gerontology International. 2017 ; Vol. 17, No. 7. pp. 1069-1075.
@article{50c4782d9deb48d89dc213f60ef20062,
title = "Association of metabolic syndrome and 25-hydroxyvitamin D with cognitive impairment among elderly Koreans",
abstract = "Aim: Metabolic syndrome and vitamin D deficiency are prevalent in older adults, and are considered risk factors for cognitive impairment. We investigated the combined effects of MetS and serum 25-hydroxyvitamin D (25[OH]D) levels on cognitive function in older adults. Methods: We studied 2940 participants aged ≥65 years from the Korean Urban Rural Elderly cohort study. Metabolic syndrome was defined according to the updated Adult Treatment Panel III criteria. Serum 25(OH)D levels were categorized into four groups: <25, 25–49, 50–74 and ≥75 nmol/L. Cognitive function was assessed using the Mini-Mental State Examination. Results: Participants with cognitive impairment had higher metabolic syndrome prevalence and lower serum 25(OH)D levels than those without cognitive impairment. In univariate analysis, both metabolic syndrome and low 25(OH)D levels were associated with cognitive impairment. These associations remained unchanged after adjusting for potential confounders including age, sex, season and education. In addition, participants with metabolic syndrome and low 25(OH)D had significantly increased odds for cognitive impairment (odds ratio 3.06, 95{\%} CI 1.61–5.80) when compared with those with no metabolic syndrome and high 25(OH)D. Conclusions: Metabolic syndrome was associated with cognitive impairment, and this risk was synergistically increased when metabolic syndrome was combined with low 25(OH)D. A focus on individuals with metabolic syndrome and low 25(OH)D might be helpful to identify older adults who are at risk of cognitive impairment. Geriatr Gerontol Int 2017; 17: 1069–1075.",
author = "Lee, {Eun Young} and Lee, {Su Jin} and Kim, {Kyoung Min} and Yun, {Young Mi} and Song, {Bo Mi} and Kim, {Jong Eun} and Kim, {Hyeon Chang} and Yumie Rhee and Yoosik Youm and Kim, {Chang Oh}",
year = "2017",
month = "7",
doi = "10.1111/ggi.12826",
language = "English",
volume = "17",
pages = "1069--1075",
journal = "Geriatrics and Gerontology International",
issn = "1444-1586",
publisher = "Japan Geriatrics Society",
number = "7",

}

Association of metabolic syndrome and 25-hydroxyvitamin D with cognitive impairment among elderly Koreans. / Lee, Eun Young; Lee, Su Jin; Kim, Kyoung Min; Yun, Young Mi; Song, Bo Mi; Kim, Jong Eun; Kim, Hyeon Chang; Rhee, Yumie; Youm, Yoosik; Kim, Chang Oh.

In: Geriatrics and Gerontology International, Vol. 17, No. 7, 07.2017, p. 1069-1075.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of metabolic syndrome and 25-hydroxyvitamin D with cognitive impairment among elderly Koreans

AU - Lee, Eun Young

AU - Lee, Su Jin

AU - Kim, Kyoung Min

AU - Yun, Young Mi

AU - Song, Bo Mi

AU - Kim, Jong Eun

AU - Kim, Hyeon Chang

AU - Rhee, Yumie

AU - Youm, Yoosik

AU - Kim, Chang Oh

PY - 2017/7

Y1 - 2017/7

N2 - Aim: Metabolic syndrome and vitamin D deficiency are prevalent in older adults, and are considered risk factors for cognitive impairment. We investigated the combined effects of MetS and serum 25-hydroxyvitamin D (25[OH]D) levels on cognitive function in older adults. Methods: We studied 2940 participants aged ≥65 years from the Korean Urban Rural Elderly cohort study. Metabolic syndrome was defined according to the updated Adult Treatment Panel III criteria. Serum 25(OH)D levels were categorized into four groups: <25, 25–49, 50–74 and ≥75 nmol/L. Cognitive function was assessed using the Mini-Mental State Examination. Results: Participants with cognitive impairment had higher metabolic syndrome prevalence and lower serum 25(OH)D levels than those without cognitive impairment. In univariate analysis, both metabolic syndrome and low 25(OH)D levels were associated with cognitive impairment. These associations remained unchanged after adjusting for potential confounders including age, sex, season and education. In addition, participants with metabolic syndrome and low 25(OH)D had significantly increased odds for cognitive impairment (odds ratio 3.06, 95% CI 1.61–5.80) when compared with those with no metabolic syndrome and high 25(OH)D. Conclusions: Metabolic syndrome was associated with cognitive impairment, and this risk was synergistically increased when metabolic syndrome was combined with low 25(OH)D. A focus on individuals with metabolic syndrome and low 25(OH)D might be helpful to identify older adults who are at risk of cognitive impairment. Geriatr Gerontol Int 2017; 17: 1069–1075.

AB - Aim: Metabolic syndrome and vitamin D deficiency are prevalent in older adults, and are considered risk factors for cognitive impairment. We investigated the combined effects of MetS and serum 25-hydroxyvitamin D (25[OH]D) levels on cognitive function in older adults. Methods: We studied 2940 participants aged ≥65 years from the Korean Urban Rural Elderly cohort study. Metabolic syndrome was defined according to the updated Adult Treatment Panel III criteria. Serum 25(OH)D levels were categorized into four groups: <25, 25–49, 50–74 and ≥75 nmol/L. Cognitive function was assessed using the Mini-Mental State Examination. Results: Participants with cognitive impairment had higher metabolic syndrome prevalence and lower serum 25(OH)D levels than those without cognitive impairment. In univariate analysis, both metabolic syndrome and low 25(OH)D levels were associated with cognitive impairment. These associations remained unchanged after adjusting for potential confounders including age, sex, season and education. In addition, participants with metabolic syndrome and low 25(OH)D had significantly increased odds for cognitive impairment (odds ratio 3.06, 95% CI 1.61–5.80) when compared with those with no metabolic syndrome and high 25(OH)D. Conclusions: Metabolic syndrome was associated with cognitive impairment, and this risk was synergistically increased when metabolic syndrome was combined with low 25(OH)D. A focus on individuals with metabolic syndrome and low 25(OH)D might be helpful to identify older adults who are at risk of cognitive impairment. Geriatr Gerontol Int 2017; 17: 1069–1075.

UR - http://www.scopus.com/inward/record.url?scp=84994504368&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84994504368&partnerID=8YFLogxK

U2 - 10.1111/ggi.12826

DO - 10.1111/ggi.12826

M3 - Article

C2 - 27444567

AN - SCOPUS:84994504368

VL - 17

SP - 1069

EP - 1075

JO - Geriatrics and Gerontology International

JF - Geriatrics and Gerontology International

SN - 1444-1586

IS - 7

ER -