Association of non-alcoholic steatohepatitis with subclinical myocardial dysfunction in non-cirrhotic patients

Yong ho Lee, Kwang Joon Kim, Myung eun Yoo, Gyuri Kim, Hye jin Yoon, Kwanhyeong Jo, Jong Chan Youn, Mijin Yun, Junyong Park, ChiYoung Shim, byungwan lee, seokmin kang, Jong Won Ha, Bong Soo Cha, Eun Seok Kang

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular risk. Among categories of NAFLD, hepatic fibrosis is most likely to affect mortality. Myocardial function and its energy metabolism are tightly linked, which might be altered by an insulin resistant condition such as NAFLD. We investigated whether hepatic steatosis and fibrosis were associated with myocardial dysfunction relative to myocardial glucose uptake. Methods: A total of 308 patients (190 without NAFLD, 118 with NAFLD) were studied in a tertiary care hospital. Myocardial glucose uptake was evaluated at fasted state using [ 18 F]-fluorodeoxyglucose-positron emission tomography ( 18 FDG-PET). Hepatic steatosis and fibrosis were assessed by transient liver elastography (Fibroscan®) with controlled attenuation parameter, which quantifies hepatic fat and by surrogate indices (fatty liver index and NAFLD fibrosis score). Cardiac structure and function were examined by echocardiogram. Results: Compared to those without NAFLD, patients with NAFLD had alterations in cardiac remodeling, manifested by increased left ventricular mass index, left ventricular end-diastolic diameter, and left atrial volume index (all p <0.05). Hepatic steatosis was significantly associated with left ventricular filling pressure (E/e’ ratio), which reflects diastolic dysfunction (p for trend <0.05). Those without NAFLD were more likely to have higher myocardial glucose uptake compared to those with NAFLD. Significant hepatic fibrosis was also correlated with diastolic dysfunction and impaired myocardial glucose uptake. Using multivariable linear regression, E/e’ ratio was independently associated with hepatic fibrosis (standardized β = 0.12 to 0.27; all p <0.05). Association between hepatic steatosis and E/e’ ratio was also significant (standardized β = 0.10 to 0.15; all p <0.05 excluding the model adjusted for adiposity). Conclusions: Hepatic steatosis and fibrosis are significantly associated with diastolic heart dysfunction. This association is linked with myocardial glucose uptake evaluated by 18 FDG-PET. Lay summary: Non-alcoholic fatty liver disease is associated with an increased risk of cardiovascular disease. More severe forms of non-alcoholic fatty liver disease, where hepatic fibrosis occurs, are linked to increased mortality. In this study, we have shown that hepatic steatosis and fibrosis are associated with subclinical myocardial dysfunction. This association is linked to altered myocardial glucose uptake.

Original languageEnglish
Pages (from-to)764-772
Number of pages9
JournalJournal of Hepatology
Volume68
Issue number4
DOIs
Publication statusPublished - 2018 Apr 1

Fingerprint

Fatty Liver
Liver
Fibrosis
Glucose
Fluorodeoxyglucose F18
Positron-Emission Tomography
Non-alcoholic Fatty Liver Disease
Elasticity Imaging Techniques
Mortality
Adiposity
Ventricular Pressure
Tertiary Healthcare
Tertiary Care Centers
Liver Cirrhosis
Energy Metabolism
Linear Models
Cardiovascular Diseases
Fats
Insulin

All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

Lee, Yong ho ; Kim, Kwang Joon ; Yoo, Myung eun ; Kim, Gyuri ; Yoon, Hye jin ; Jo, Kwanhyeong ; Youn, Jong Chan ; Yun, Mijin ; Park, Junyong ; Shim, ChiYoung ; lee, byungwan ; kang, seokmin ; Ha, Jong Won ; Cha, Bong Soo ; Kang, Eun Seok. / Association of non-alcoholic steatohepatitis with subclinical myocardial dysfunction in non-cirrhotic patients. In: Journal of Hepatology. 2018 ; Vol. 68, No. 4. pp. 764-772.
@article{135b9eea538e4e11aed087aab8065264,
title = "Association of non-alcoholic steatohepatitis with subclinical myocardial dysfunction in non-cirrhotic patients",
abstract = "Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular risk. Among categories of NAFLD, hepatic fibrosis is most likely to affect mortality. Myocardial function and its energy metabolism are tightly linked, which might be altered by an insulin resistant condition such as NAFLD. We investigated whether hepatic steatosis and fibrosis were associated with myocardial dysfunction relative to myocardial glucose uptake. Methods: A total of 308 patients (190 without NAFLD, 118 with NAFLD) were studied in a tertiary care hospital. Myocardial glucose uptake was evaluated at fasted state using [ 18 F]-fluorodeoxyglucose-positron emission tomography ( 18 FDG-PET). Hepatic steatosis and fibrosis were assessed by transient liver elastography (Fibroscan{\circledR}) with controlled attenuation parameter, which quantifies hepatic fat and by surrogate indices (fatty liver index and NAFLD fibrosis score). Cardiac structure and function were examined by echocardiogram. Results: Compared to those without NAFLD, patients with NAFLD had alterations in cardiac remodeling, manifested by increased left ventricular mass index, left ventricular end-diastolic diameter, and left atrial volume index (all p <0.05). Hepatic steatosis was significantly associated with left ventricular filling pressure (E/e’ ratio), which reflects diastolic dysfunction (p for trend <0.05). Those without NAFLD were more likely to have higher myocardial glucose uptake compared to those with NAFLD. Significant hepatic fibrosis was also correlated with diastolic dysfunction and impaired myocardial glucose uptake. Using multivariable linear regression, E/e’ ratio was independently associated with hepatic fibrosis (standardized β = 0.12 to 0.27; all p <0.05). Association between hepatic steatosis and E/e’ ratio was also significant (standardized β = 0.10 to 0.15; all p <0.05 excluding the model adjusted for adiposity). Conclusions: Hepatic steatosis and fibrosis are significantly associated with diastolic heart dysfunction. This association is linked with myocardial glucose uptake evaluated by 18 FDG-PET. Lay summary: Non-alcoholic fatty liver disease is associated with an increased risk of cardiovascular disease. More severe forms of non-alcoholic fatty liver disease, where hepatic fibrosis occurs, are linked to increased mortality. In this study, we have shown that hepatic steatosis and fibrosis are associated with subclinical myocardial dysfunction. This association is linked to altered myocardial glucose uptake.",
author = "Lee, {Yong ho} and Kim, {Kwang Joon} and Yoo, {Myung eun} and Gyuri Kim and Yoon, {Hye jin} and Kwanhyeong Jo and Youn, {Jong Chan} and Mijin Yun and Junyong Park and ChiYoung Shim and byungwan lee and seokmin kang and Ha, {Jong Won} and Cha, {Bong Soo} and Kang, {Eun Seok}",
year = "2018",
month = "4",
day = "1",
doi = "10.1016/j.jhep.2017.11.023",
language = "English",
volume = "68",
pages = "764--772",
journal = "Journal of Hepatology",
issn = "0168-8278",
publisher = "Elsevier",
number = "4",

}

Association of non-alcoholic steatohepatitis with subclinical myocardial dysfunction in non-cirrhotic patients. / Lee, Yong ho; Kim, Kwang Joon; Yoo, Myung eun; Kim, Gyuri; Yoon, Hye jin; Jo, Kwanhyeong; Youn, Jong Chan; Yun, Mijin; Park, Junyong; Shim, ChiYoung; lee, byungwan; kang, seokmin; Ha, Jong Won; Cha, Bong Soo; Kang, Eun Seok.

In: Journal of Hepatology, Vol. 68, No. 4, 01.04.2018, p. 764-772.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Association of non-alcoholic steatohepatitis with subclinical myocardial dysfunction in non-cirrhotic patients

AU - Lee, Yong ho

AU - Kim, Kwang Joon

AU - Yoo, Myung eun

AU - Kim, Gyuri

AU - Yoon, Hye jin

AU - Jo, Kwanhyeong

AU - Youn, Jong Chan

AU - Yun, Mijin

AU - Park, Junyong

AU - Shim, ChiYoung

AU - lee, byungwan

AU - kang, seokmin

AU - Ha, Jong Won

AU - Cha, Bong Soo

AU - Kang, Eun Seok

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular risk. Among categories of NAFLD, hepatic fibrosis is most likely to affect mortality. Myocardial function and its energy metabolism are tightly linked, which might be altered by an insulin resistant condition such as NAFLD. We investigated whether hepatic steatosis and fibrosis were associated with myocardial dysfunction relative to myocardial glucose uptake. Methods: A total of 308 patients (190 without NAFLD, 118 with NAFLD) were studied in a tertiary care hospital. Myocardial glucose uptake was evaluated at fasted state using [ 18 F]-fluorodeoxyglucose-positron emission tomography ( 18 FDG-PET). Hepatic steatosis and fibrosis were assessed by transient liver elastography (Fibroscan®) with controlled attenuation parameter, which quantifies hepatic fat and by surrogate indices (fatty liver index and NAFLD fibrosis score). Cardiac structure and function were examined by echocardiogram. Results: Compared to those without NAFLD, patients with NAFLD had alterations in cardiac remodeling, manifested by increased left ventricular mass index, left ventricular end-diastolic diameter, and left atrial volume index (all p <0.05). Hepatic steatosis was significantly associated with left ventricular filling pressure (E/e’ ratio), which reflects diastolic dysfunction (p for trend <0.05). Those without NAFLD were more likely to have higher myocardial glucose uptake compared to those with NAFLD. Significant hepatic fibrosis was also correlated with diastolic dysfunction and impaired myocardial glucose uptake. Using multivariable linear regression, E/e’ ratio was independently associated with hepatic fibrosis (standardized β = 0.12 to 0.27; all p <0.05). Association between hepatic steatosis and E/e’ ratio was also significant (standardized β = 0.10 to 0.15; all p <0.05 excluding the model adjusted for adiposity). Conclusions: Hepatic steatosis and fibrosis are significantly associated with diastolic heart dysfunction. This association is linked with myocardial glucose uptake evaluated by 18 FDG-PET. Lay summary: Non-alcoholic fatty liver disease is associated with an increased risk of cardiovascular disease. More severe forms of non-alcoholic fatty liver disease, where hepatic fibrosis occurs, are linked to increased mortality. In this study, we have shown that hepatic steatosis and fibrosis are associated with subclinical myocardial dysfunction. This association is linked to altered myocardial glucose uptake.

AB - Background & Aims: Non-alcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular risk. Among categories of NAFLD, hepatic fibrosis is most likely to affect mortality. Myocardial function and its energy metabolism are tightly linked, which might be altered by an insulin resistant condition such as NAFLD. We investigated whether hepatic steatosis and fibrosis were associated with myocardial dysfunction relative to myocardial glucose uptake. Methods: A total of 308 patients (190 without NAFLD, 118 with NAFLD) were studied in a tertiary care hospital. Myocardial glucose uptake was evaluated at fasted state using [ 18 F]-fluorodeoxyglucose-positron emission tomography ( 18 FDG-PET). Hepatic steatosis and fibrosis were assessed by transient liver elastography (Fibroscan®) with controlled attenuation parameter, which quantifies hepatic fat and by surrogate indices (fatty liver index and NAFLD fibrosis score). Cardiac structure and function were examined by echocardiogram. Results: Compared to those without NAFLD, patients with NAFLD had alterations in cardiac remodeling, manifested by increased left ventricular mass index, left ventricular end-diastolic diameter, and left atrial volume index (all p <0.05). Hepatic steatosis was significantly associated with left ventricular filling pressure (E/e’ ratio), which reflects diastolic dysfunction (p for trend <0.05). Those without NAFLD were more likely to have higher myocardial glucose uptake compared to those with NAFLD. Significant hepatic fibrosis was also correlated with diastolic dysfunction and impaired myocardial glucose uptake. Using multivariable linear regression, E/e’ ratio was independently associated with hepatic fibrosis (standardized β = 0.12 to 0.27; all p <0.05). Association between hepatic steatosis and E/e’ ratio was also significant (standardized β = 0.10 to 0.15; all p <0.05 excluding the model adjusted for adiposity). Conclusions: Hepatic steatosis and fibrosis are significantly associated with diastolic heart dysfunction. This association is linked with myocardial glucose uptake evaluated by 18 FDG-PET. Lay summary: Non-alcoholic fatty liver disease is associated with an increased risk of cardiovascular disease. More severe forms of non-alcoholic fatty liver disease, where hepatic fibrosis occurs, are linked to increased mortality. In this study, we have shown that hepatic steatosis and fibrosis are associated with subclinical myocardial dysfunction. This association is linked to altered myocardial glucose uptake.

UR - http://www.scopus.com/inward/record.url?scp=85040445290&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85040445290&partnerID=8YFLogxK

U2 - 10.1016/j.jhep.2017.11.023

DO - 10.1016/j.jhep.2017.11.023

M3 - Article

C2 - 29175242

AN - SCOPUS:85040445290

VL - 68

SP - 764

EP - 772

JO - Journal of Hepatology

JF - Journal of Hepatology

SN - 0168-8278

IS - 4

ER -