Association of oral contraceptive use with suicidal behavior among representative Korean population: Results from Korea National Health and Nutrition Examination Survey (2007–2016)

Sun Jae Jung, So Mi J. Cho, HyeonChang Kim

Research output: Contribution to journalArticle

Abstract

Introduction: The association of suicide with the use of oral contraceptives (OC) is unknown in the Asian population. We aimed to evaluate the association of OC use and suicidal behavior in a nationally representative population of Korean women. Method: Of the 44,501 women who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) (2007–2016), 27,067 women aged 20 years or older who had completed information on OC use and suicidal behavior were included. Women with a history of cancer were excluded. Compared to non-users of OC, odds ratios (ORs) for suicide attempt/ideation were calculated using a multivariable logistic regression among OC users, with testing of the interaction term of OC use and history of depression. We also conducted a stratified analysis by history of depression. Results: A total of 4,067 women (14.0%) reported they had suicide ideations or had attempted suicide, respectively. OC use was associated with an increased prevalence of suicidality (OR = 1.13, 95% CI 1.00–1.24) after adjustments for age, demographic factors, age of menarche, and lifestyle behaviors. When stratified by history of depression diagnosis, ORs linearly increased as the total duration of OC use lengthened among women with a history of depression; however, women without a history of depression showed peaked OR at 4- to 12-month use. Conclusion: There is an increased association between OC use and suicidality and the pattern of the relationship differs depending on whether there is a history of depression.

LanguageEnglish
Pages8-15
Number of pages8
JournalJournal of Affective Disorders
Volume243
DOIs
Publication statusPublished - 2019 Jan 15

Fingerprint

Nutrition Surveys
Korea
Oral Contraceptives
Depression
Population
Odds Ratio
Suicide
Attempted Suicide
Reproductive History
Menarche
Age Factors
Life Style
Logistic Models
Demography
Interviews

All Science Journal Classification (ASJC) codes

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

@article{68207022cecf460ea156ea2b71a7b203,
title = "Association of oral contraceptive use with suicidal behavior among representative Korean population: Results from Korea National Health and Nutrition Examination Survey (2007–2016)",
abstract = "Introduction: The association of suicide with the use of oral contraceptives (OC) is unknown in the Asian population. We aimed to evaluate the association of OC use and suicidal behavior in a nationally representative population of Korean women. Method: Of the 44,501 women who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) (2007–2016), 27,067 women aged 20 years or older who had completed information on OC use and suicidal behavior were included. Women with a history of cancer were excluded. Compared to non-users of OC, odds ratios (ORs) for suicide attempt/ideation were calculated using a multivariable logistic regression among OC users, with testing of the interaction term of OC use and history of depression. We also conducted a stratified analysis by history of depression. Results: A total of 4,067 women (14.0{\%}) reported they had suicide ideations or had attempted suicide, respectively. OC use was associated with an increased prevalence of suicidality (OR = 1.13, 95{\%} CI 1.00–1.24) after adjustments for age, demographic factors, age of menarche, and lifestyle behaviors. When stratified by history of depression diagnosis, ORs linearly increased as the total duration of OC use lengthened among women with a history of depression; however, women without a history of depression showed peaked OR at 4- to 12-month use. Conclusion: There is an increased association between OC use and suicidality and the pattern of the relationship differs depending on whether there is a history of depression.",
author = "Jung, {Sun Jae} and Cho, {So Mi J.} and HyeonChang Kim",
year = "2019",
month = "1",
day = "15",
doi = "10.1016/j.jad.2018.09.004",
language = "English",
volume = "243",
pages = "8--15",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier",

}

TY - JOUR

T1 - Association of oral contraceptive use with suicidal behavior among representative Korean population

T2 - Journal of Affective Disorders

AU - Jung, Sun Jae

AU - Cho, So Mi J.

AU - Kim, HyeonChang

PY - 2019/1/15

Y1 - 2019/1/15

N2 - Introduction: The association of suicide with the use of oral contraceptives (OC) is unknown in the Asian population. We aimed to evaluate the association of OC use and suicidal behavior in a nationally representative population of Korean women. Method: Of the 44,501 women who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) (2007–2016), 27,067 women aged 20 years or older who had completed information on OC use and suicidal behavior were included. Women with a history of cancer were excluded. Compared to non-users of OC, odds ratios (ORs) for suicide attempt/ideation were calculated using a multivariable logistic regression among OC users, with testing of the interaction term of OC use and history of depression. We also conducted a stratified analysis by history of depression. Results: A total of 4,067 women (14.0%) reported they had suicide ideations or had attempted suicide, respectively. OC use was associated with an increased prevalence of suicidality (OR = 1.13, 95% CI 1.00–1.24) after adjustments for age, demographic factors, age of menarche, and lifestyle behaviors. When stratified by history of depression diagnosis, ORs linearly increased as the total duration of OC use lengthened among women with a history of depression; however, women without a history of depression showed peaked OR at 4- to 12-month use. Conclusion: There is an increased association between OC use and suicidality and the pattern of the relationship differs depending on whether there is a history of depression.

AB - Introduction: The association of suicide with the use of oral contraceptives (OC) is unknown in the Asian population. We aimed to evaluate the association of OC use and suicidal behavior in a nationally representative population of Korean women. Method: Of the 44,501 women who participated in the Korea National Health and Nutrition Examination Survey (KNHANES) (2007–2016), 27,067 women aged 20 years or older who had completed information on OC use and suicidal behavior were included. Women with a history of cancer were excluded. Compared to non-users of OC, odds ratios (ORs) for suicide attempt/ideation were calculated using a multivariable logistic regression among OC users, with testing of the interaction term of OC use and history of depression. We also conducted a stratified analysis by history of depression. Results: A total of 4,067 women (14.0%) reported they had suicide ideations or had attempted suicide, respectively. OC use was associated with an increased prevalence of suicidality (OR = 1.13, 95% CI 1.00–1.24) after adjustments for age, demographic factors, age of menarche, and lifestyle behaviors. When stratified by history of depression diagnosis, ORs linearly increased as the total duration of OC use lengthened among women with a history of depression; however, women without a history of depression showed peaked OR at 4- to 12-month use. Conclusion: There is an increased association between OC use and suicidality and the pattern of the relationship differs depending on whether there is a history of depression.

UR - http://www.scopus.com/inward/record.url?scp=85053334018&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85053334018&partnerID=8YFLogxK

U2 - 10.1016/j.jad.2018.09.004

DO - 10.1016/j.jad.2018.09.004

M3 - Article

VL - 243

SP - 8

EP - 15

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -