Association of plasma osteoprotegerin levels with stroke severity and functional outcome in acute ischaemic stroke patients

Tae Jin Song, Jinkwon Kim, Seung Hee Yang, Ji Hye Park, Hye Sun Lee, Chung Mo Nam, Ok Hee Lee, Young Dae Kim, Hyo Suk Nam, Ji Hoe Heo

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Osteoprotegerin (OPG) is known to regulate processes involved in vascular injury and inflammation. We investigated the relationship between plasma OPG levels and stroke subtype, stroke severity at admission and functional outcome at 3 months in 172 patients with acute ischaemic stroke. Patients with large artery atherosclerosis and those with multiple causes had higher plasma OPG levels than patients with lacune. Increased plasma OPG levels were independently associated with more severe stroke and poor functional outcome. These results suggest pleiotropic roles of OPG in mediating atherosclerosis and ischaemic brain injury. OPG is a potential biomarker for predicting neurologic outcome in stroke.

Original languageEnglish
Pages (from-to)738-744
Number of pages7
JournalBiomarkers
Volume17
Issue number8
DOIs
Publication statusPublished - 2012 Dec

Bibliographical note

Funding Information:
This work was supported by a grant from the Korea Healthcare Technology Research and Development Project, Ministry for Health, Welfare, and Family Affairs, Republic of Korea (A060171, A085136).

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Fingerprint

Dive into the research topics of 'Association of plasma osteoprotegerin levels with stroke severity and functional outcome in acute ischaemic stroke patients'. Together they form a unique fingerprint.

Cite this