Association of polyfluoroalkyl chemical exposure with serum lipids in children

Xiao Wen Zeng, Zhengmin Qian, Brett Emo, Michael George Vaughn, Jia Bao, Xiao Di Qin, Yu Zhu, Jie Li, Yungling Leo Lee, Guang Hui Dong

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Perfluoroalkyl and polyfluoroalkyl substances (PFASs), as well as polymers of PFASs, have been widely used in commercial applications and have been detected in humans and the environment. Previous epidemiological studies have shown associations between particular PFAS chemicals and serum lipid concentrations in adults, particularly perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). There exists, however, limited information concerning the effect of PFASs have on serum lipids among children. In the present cross-sectional study, 225 Taiwanese children (12-15. years of age) were recruited to determine the relationship between serum level PFASs and lipid concentration. Results showed that eight out of ten particular PFASs were detected in the serum of >. 94% of the participants. Serum PFOS and perfluorotetradecanoic acid (PFTA) levels were at an order of magnitude higher than the other PFASs, with arithmetical means of 32.4 and 30.7. ng/ml in boys and 34.2 and 27.4. ng/ml in girls, respectively. However, the variation in serum PFTA concentration was quite large. Following covariate adjustment, linear regression models revealed that PFOS, PFOA, and perfluorononanoic acid (PFNA) were positively associated with total cholesterol (TC), low-density lipoprotein (LDL) and triglycerides (TG), particularly for PFOS and PFTA. Quartile analysis, with the lowest exposure quartile as a reference, yielded associations between serum PFTA and elevations in TC ( p= 0.002) and LDL ( p= 0.004). Though not statistically significant, high-density lipoprotein (HDL) appeared to decrease linearly across quartiles for PFOS and PFOA exposure. In conclusion, a significant association was observed between serum PFASs and lipid level in Taiwanese children. These findings for PFTA are novel, and emphasize the need to investigate the exposure route and toxicological evidence of PFASs beyond PFOS and PFOA.

Original languageEnglish
Pages (from-to)364-370
Number of pages7
JournalScience of the Total Environment
Volume512-513
DOIs
Publication statusPublished - 2015 Apr 5

Fingerprint

perfluorooctanoic acid
Lipids
serum
lipid
Acids
acid
Lipoproteins
Cholesterol
HDL Lipoproteins
LDL Lipoproteins
Linear regression
perfluorooctane sulfonic acid
exposure
chemical
Polymers

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution

Cite this

Zeng, Xiao Wen ; Qian, Zhengmin ; Emo, Brett ; Vaughn, Michael George ; Bao, Jia ; Qin, Xiao Di ; Zhu, Yu ; Li, Jie ; Lee, Yungling Leo ; Dong, Guang Hui. / Association of polyfluoroalkyl chemical exposure with serum lipids in children. In: Science of the Total Environment. 2015 ; Vol. 512-513. pp. 364-370.
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title = "Association of polyfluoroalkyl chemical exposure with serum lipids in children",
abstract = "Perfluoroalkyl and polyfluoroalkyl substances (PFASs), as well as polymers of PFASs, have been widely used in commercial applications and have been detected in humans and the environment. Previous epidemiological studies have shown associations between particular PFAS chemicals and serum lipid concentrations in adults, particularly perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). There exists, however, limited information concerning the effect of PFASs have on serum lipids among children. In the present cross-sectional study, 225 Taiwanese children (12-15. years of age) were recruited to determine the relationship between serum level PFASs and lipid concentration. Results showed that eight out of ten particular PFASs were detected in the serum of >. 94{\%} of the participants. Serum PFOS and perfluorotetradecanoic acid (PFTA) levels were at an order of magnitude higher than the other PFASs, with arithmetical means of 32.4 and 30.7. ng/ml in boys and 34.2 and 27.4. ng/ml in girls, respectively. However, the variation in serum PFTA concentration was quite large. Following covariate adjustment, linear regression models revealed that PFOS, PFOA, and perfluorononanoic acid (PFNA) were positively associated with total cholesterol (TC), low-density lipoprotein (LDL) and triglycerides (TG), particularly for PFOS and PFTA. Quartile analysis, with the lowest exposure quartile as a reference, yielded associations between serum PFTA and elevations in TC ( p= 0.002) and LDL ( p= 0.004). Though not statistically significant, high-density lipoprotein (HDL) appeared to decrease linearly across quartiles for PFOS and PFOA exposure. In conclusion, a significant association was observed between serum PFASs and lipid level in Taiwanese children. These findings for PFTA are novel, and emphasize the need to investigate the exposure route and toxicological evidence of PFASs beyond PFOS and PFOA.",
author = "Zeng, {Xiao Wen} and Zhengmin Qian and Brett Emo and Vaughn, {Michael George} and Jia Bao and Qin, {Xiao Di} and Yu Zhu and Jie Li and Lee, {Yungling Leo} and Dong, {Guang Hui}",
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Zeng, XW, Qian, Z, Emo, B, Vaughn, MG, Bao, J, Qin, XD, Zhu, Y, Li, J, Lee, YL & Dong, GH 2015, 'Association of polyfluoroalkyl chemical exposure with serum lipids in children', Science of the Total Environment, vol. 512-513, pp. 364-370. https://doi.org/10.1016/j.scitotenv.2015.01.042

Association of polyfluoroalkyl chemical exposure with serum lipids in children. / Zeng, Xiao Wen; Qian, Zhengmin; Emo, Brett; Vaughn, Michael George; Bao, Jia; Qin, Xiao Di; Zhu, Yu; Li, Jie; Lee, Yungling Leo; Dong, Guang Hui.

In: Science of the Total Environment, Vol. 512-513, 05.04.2015, p. 364-370.

Research output: Contribution to journalArticle

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T1 - Association of polyfluoroalkyl chemical exposure with serum lipids in children

AU - Zeng, Xiao Wen

AU - Qian, Zhengmin

AU - Emo, Brett

AU - Vaughn, Michael George

AU - Bao, Jia

AU - Qin, Xiao Di

AU - Zhu, Yu

AU - Li, Jie

AU - Lee, Yungling Leo

AU - Dong, Guang Hui

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Y1 - 2015/4/5

N2 - Perfluoroalkyl and polyfluoroalkyl substances (PFASs), as well as polymers of PFASs, have been widely used in commercial applications and have been detected in humans and the environment. Previous epidemiological studies have shown associations between particular PFAS chemicals and serum lipid concentrations in adults, particularly perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). There exists, however, limited information concerning the effect of PFASs have on serum lipids among children. In the present cross-sectional study, 225 Taiwanese children (12-15. years of age) were recruited to determine the relationship between serum level PFASs and lipid concentration. Results showed that eight out of ten particular PFASs were detected in the serum of >. 94% of the participants. Serum PFOS and perfluorotetradecanoic acid (PFTA) levels were at an order of magnitude higher than the other PFASs, with arithmetical means of 32.4 and 30.7. ng/ml in boys and 34.2 and 27.4. ng/ml in girls, respectively. However, the variation in serum PFTA concentration was quite large. Following covariate adjustment, linear regression models revealed that PFOS, PFOA, and perfluorononanoic acid (PFNA) were positively associated with total cholesterol (TC), low-density lipoprotein (LDL) and triglycerides (TG), particularly for PFOS and PFTA. Quartile analysis, with the lowest exposure quartile as a reference, yielded associations between serum PFTA and elevations in TC ( p= 0.002) and LDL ( p= 0.004). Though not statistically significant, high-density lipoprotein (HDL) appeared to decrease linearly across quartiles for PFOS and PFOA exposure. In conclusion, a significant association was observed between serum PFASs and lipid level in Taiwanese children. These findings for PFTA are novel, and emphasize the need to investigate the exposure route and toxicological evidence of PFASs beyond PFOS and PFOA.

AB - Perfluoroalkyl and polyfluoroalkyl substances (PFASs), as well as polymers of PFASs, have been widely used in commercial applications and have been detected in humans and the environment. Previous epidemiological studies have shown associations between particular PFAS chemicals and serum lipid concentrations in adults, particularly perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA). There exists, however, limited information concerning the effect of PFASs have on serum lipids among children. In the present cross-sectional study, 225 Taiwanese children (12-15. years of age) were recruited to determine the relationship between serum level PFASs and lipid concentration. Results showed that eight out of ten particular PFASs were detected in the serum of >. 94% of the participants. Serum PFOS and perfluorotetradecanoic acid (PFTA) levels were at an order of magnitude higher than the other PFASs, with arithmetical means of 32.4 and 30.7. ng/ml in boys and 34.2 and 27.4. ng/ml in girls, respectively. However, the variation in serum PFTA concentration was quite large. Following covariate adjustment, linear regression models revealed that PFOS, PFOA, and perfluorononanoic acid (PFNA) were positively associated with total cholesterol (TC), low-density lipoprotein (LDL) and triglycerides (TG), particularly for PFOS and PFTA. Quartile analysis, with the lowest exposure quartile as a reference, yielded associations between serum PFTA and elevations in TC ( p= 0.002) and LDL ( p= 0.004). Though not statistically significant, high-density lipoprotein (HDL) appeared to decrease linearly across quartiles for PFOS and PFOA exposure. In conclusion, a significant association was observed between serum PFASs and lipid level in Taiwanese children. These findings for PFTA are novel, and emphasize the need to investigate the exposure route and toxicological evidence of PFASs beyond PFOS and PFOA.

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